• Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies

    Cortes Garcia E, Giarraputo A, Racapé M, Goutaudier V, Ursule-Dufait C, de la Grange P, Adoux L, Raynaud M, Couderau C, Mezine F, Dagobert J, Bestard O, Moreso F, Villard J, Halleck F, Giral M, Brouard S, Danger R, Gourraud PA, Rabant M, Couzi L, Le Quintrec M, Kamar N, Morelon E, Vrtovsnik F, Taupin JL, Snanoudj R, Legendre C, Anglicheau D, Budde K, Lefaucheur C, Loupy A, Aubert O.

    Transpl Int. 2024 Jul 10 / 39050190

  • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

    Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

    Immunology. 2024 Jul 2 / 38953295

  • Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer

    Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette

    J Exp Clin Cancer Res. 2024 Feb 27 / 38413979

  • Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

    Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

    Nucleic Acids Res. 2024 Feb 7 / 38324473

  • A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner

    Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele

    Cell Rep. Mar 28 / 36862556

  • BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance

    Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer

    Cancer Discov. 2023 Nov 1 / 37623817

  • Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression

    Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue

    J Invest Dermatol. 2023 Sep 20 / 37739336

  • Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

    David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall

    Cell Rep. 2023 Sep 13 / 37708024

  • Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

    Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz

    JHEP Rep. 2023 May 16 / 37520673

  • Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs

    Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm

    Front Mol Neurosci. 2023 May 5 / 37266374

  • Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity

    Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl

    Cell Mol Life Sci. 2023 May 15 / 37184603

  • Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology

    Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel

    Exp Dermatol. 2023 May 6 / 37148203

  • CDK12/13 promote splicing of proximal introns by enhancing the
    interaction between RNA polymerase II and the splicing factor SF3B1

    Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

    Nucleic Acids Res. 2023 Apr 7 / 37026485

  • CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

    Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

    Nucleic Acids Res. 2023 Apr 7 / 37026485

  • MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

    Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn

    Nat Commun. 2023 Apr 1 / 37005415

  • T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions

    Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros

    Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942

  • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
    Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas Dulphy

    Nat Commun. 2023 Feb 03 / 36737440

  • RELA tunes innate-like interferon I/III responses in human T cells
    Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas Manel

    J Exp Med. 2023 Feb 23 / 36820829

  • Integrative genetic analysis illuminates ALS heritability and identifies risk genes
    Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc Dupuis

    Nat Commun. 2023 May 1/ 36670122

  • Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
    Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca Amati

    Int J Mol Sci. 2023 Jan 6 / 36674633

  • Cortical wiring by synapse type-specific control of local protein synthesis
    Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar Marín

    Science. 2022 Nov 25 / 36423280

  • The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
    Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-Kourbali

    Br J Cancer. 2022 Dec 22 / 36550208

  • RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
    Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan Stamm

    Nucleic Acids Res. 2022 Dec 19 / 36533443

  • Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.

    Olivier Ariste, Pierre de la Grange, Reiner A Veitia

    Clin Genet. 2022 Nov 10 / PMID: 36353970

  • Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.

    Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger

    EMBO J. 2022 Sep 23 / PMID: 36149731

  • A conserved molecular template underlies color pattern diversity in estrildid finches.

    Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau

    Sci Adv. 2022 Sep 2 / PMID: 36044564

  • RNF213-associated urticarial lesions with hypercytokinemia

    Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
    Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
    Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
    De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
    Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
    Irina Giurgea

     J Allergy Clin Immunol. 2022 Jun 30  / PMID: 35780935

  • Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

    Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine

    Aging. 2022 May 4 / PMID: 35507806

  • Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

    Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm

    Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103

  • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients

    Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella

    Blood. 2022 Mar 24 / PMID: 34905599

    • Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

      Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin

      Brain. 2022 Mar 17 / PMID: 35298632

    • Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data

      Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet

      Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653

    • CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

      Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu

      Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489

    • Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia

    Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin

     Brain. 2022 Jan 4 / PMID: 34983064

    • The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
    Chiara Naro, Monica De Musso, Francesca Delle Monache, Valentina Panzeri, Pierre de la Grange, Claudio Sette
    J Exp Clin Cancer Res. 2021 Dec 20 / PMID: 34930366
    • Epithelial colonization by gut dendritic cells promotes their functional diversification

    Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil

    Immunity. December 14, 2021

    https://www.sciencedirect.com/science/article/pii/S1074761321004994

    • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients

    Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella

    Blood. 2021 Dec 14 / PMID: 34905599

    • BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

    Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua

    Int J Mol Sci. 2021 Sep 30 / PMID: 34638998

    • Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
    Daphné Krzisch, Nayara Guedes, Clémentine Boccon-Gibod, Marine Baron,
    Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
    Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
    Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
    Leukemia Organization) group
    Am J Hematol. 2021 Aug 31 / PMID: 34462944
    • Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
    Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour,
    Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
    Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
    Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
    Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
    Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
    Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
    Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
    Guido Kroemer, Jonathan G Pol
    J Exp Med. 2021 Oct 4 / PMID: 34495298
    • Genes coding for transcription factors involved in stem cell
      maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
      COPD bronchial epithelial progenitors.

    Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.

    Mol Biol Rep. 2021 Aug 26 / PMID: 34436724

    • Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.

    Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
    la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.

    Cereb Cortex. 2021 May 21 / PMID: 34023893

    • Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
    E El Khouri, J Ghoumid, D Haye, F Giuliano, L Drevillon, A
    Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
    Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
    Mol Psychiatry. 2021 Apr 19. / PMID: 33867523
    • Activation of Macrophages by Lysophosphatidic Acid through
      the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
      Sclerosis Pathogenesis.

    Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
    Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
    Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
    Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.

    Mol Neurobiol. 2021 Feb / PMID: 32974731

    ·         Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

    Emmanuel
    Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
    Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
    Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
    Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
    Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
    Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5

     

    ·         Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.

    Ben
    Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
    Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
    10.1007/s12015-021-10123-z.

     

    ·         Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
    with oligodendroglial hyperplasia in epilepsy (MOGHE)

    Thomas
    Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
    Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
    Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
    Blumcke, Stéphanie Baulac

    Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.

     

    ·         Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?

    Lerebours
    F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
    S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.

    J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.

     

    ·         Plasma microRNA signature in presymptomatic and symptomatic subjects with
    C9orf72-associated frontotemporal dementia and amyotrophic lateral
    sclerosis.

    Kmetzsch
    V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
    Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
    Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.

    J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.

     

    ·         Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

    Casulleras
    M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
    López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
    Moreau R, Arroyo V, Clària J.

    Sci Transl Med. 2020 Oct 21;12(566):eaax5135.

     

    ·         Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

    Chiot
    A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
    Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
    Boillée S.

    Nat Neurosci. 2020 Oct 19.

     

    ·         Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

    Bogdan
    Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
    Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos

    Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.

     

    ·         Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.

     

    Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli

    Cell Rep. 2020 Apr 14 / PMID: 32294449

     

    ·         Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.

    Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.

    Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019

     

    ·         Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.

    Romagnoli
    M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
    Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
    MA, Glukhova MA, Faraldo MM.

    Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552

     

    ·         ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.

    Gacem
    N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
    Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.

    Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5

     

    ·         Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.

    Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.

    Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117

     

    ·         An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

    Traoré
    M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
    Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
    Falcone S

    Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131

     

    ·         A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

    Lévesque
    S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
    EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
    Kroemer G, Pol JG

    Oncoimmunology. 2019 Sep 7;8(11):e1657375

     

    ·         SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.

    Leman
    R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
    Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S

    Bioinformatics. 2019 Oct 16. pii: btz784

     

    ·         Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

    Furlanis E, Traunmüller L, Fucile G, Scheiffele P.

    Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5

     

    ·         Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

    Baldassari
    S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
    C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
    M, Baulac S

    Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

     

    ·         Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

    Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S

    Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861

     

    ·         Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

    Sica
    V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
    Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
    Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
    Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

    Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

     

    ·         Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

    Liu
    P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
    Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
    Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
    Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
    Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

    Nat Commun. 2019 Apr 2;10(1):1486

     

    ·         Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

    Romagnoli
    M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
    Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
    Raymond K, Glukhova MA, Faraldo MM.

    Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6

     

    ·         Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
    differentiation-dependent metabolic responses to IFNG stimulation.

    Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.

    Cell Death Dis. 2019 Mar 20;10(4):277

     

    ·         Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.

    Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.

    Cell Rep. 2019 Mar 12;26(11):2929-2941

     

    ·         p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.

    Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.

    Breast Cancer Res. 2019 Jan 25;21(1):13

     

    ·         Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

    Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

    Sci Rep. 2019 Jan 28;9(1):792

     

    ·         Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.

    Daruich
    A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
    JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.

    Sci Adv. 2019 Jan 9;5(1):eaau9940

     

    ·         Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

    Domenech
    C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
    Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.

    Stem Cell Reports 2018, Nov 13;11(5):1075-1091

     

    ·         The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

    Tury
    S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
    V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
    Lallemand F, Marangoni E, Bièche I, Callens C.

    J Pathol. 2018 Jun 7

     

    ·         Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.

    Bruno,
    A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
    L, Rahimian, A, Lemoine, F, de la Grange, P,   Guégan, J, Bielle, F,
    Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
    Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
    Mokhtari, K, Hoang-Xuan, K, Alentorn, A.

    Neuro Oncol. 2018 Jul 5;20(8):1092-1100

     

    ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

    Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

    Sci Rep. 2017 Dec 14;7(1):17595.

     

    ·         Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

    Cifdaloz
    M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
    Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
    E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
    Megías D, Valcárcel J, Soengas MS.

    Nat Commun. 2017 Dec 21;8(1):2249.

     

    ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

    Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

    Sci Rep. 2017 Dec 14;7(1):17595

     

    ·         Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

    Glentis
    A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
    Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
    Plodinec M, Vignjevic DM.

    Nat Commun. 2017 Oct 13;8(1):924.

     

    ·         hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell

    Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.

    Nucleic Acids Res. 2017 Oct 3

    ·         Neurotrophic factors for motor neurons: an à la carte menu

    Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.

    Med Sci (Paris). 2017 Oct;33(10):835-839

     

    ·         Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.

    Grégoire
    Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
    Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
    Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
    Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
    Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
    Alexandra Martins, Dominique Vaur, Sophie Krieger.

    Eur J Hum Genet. 2017 Oct;25(10):1147-1154

     

    ·         Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
    and Sensitivity to the DNA Repair Inhibitor AsiDNA.

    Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.

    Cancer Res. 2017 Aug 15;77(16):4207-4216

     

    ·         Pre-therapy liver transcriptome landscape in Indian and French patients with severe
    alcoholic hepatitis and steroid responsiveness

    Shvetank
    Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
    Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
    Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
    Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
    Richard Moreau & Shiv K. Sarin.

    Scientific Reports 2017 Jul 28;7(1):6816

     

    ·         Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

    Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.

    Nucleic Acids Res. 2017 Jun 7

     

    ·         Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

    Boulay
    AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
    Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
    Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.

    Cell Discov. 2017 Mar 28

     

    ·         An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation

    Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.

    Developmental Cell 2017 Mar 24

     

    ·         Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

    Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

    Proc Natl Acad Sci U S A. 2017 Mar 7

     

    ·         Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

    Santo
    J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
    S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
    G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,

    Int J Obes (Lond). 2017

     

    ·         Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

    Weiss
    E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
    Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
    Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
    Lotersztajn S, Moreau R.,

    J Hepatol. 2016 Dec 28

     

    ·         Deregulation of pre-messenger RNA splicing and rare diseases.

    de la Grange P.

    Med Sci (Paris). 2016 Dec

     

    ·         Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.

    Mauger O, Lemoine F, Scheiffele P.,

    Neuron. 2016 Nov 21

     

    ·         Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
    progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.

    La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C

    Elife. 2016 Nov 15

     

    ·         Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
    Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
    Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
    Neuronal Cultures.

    Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C

    Mol Neurobiol. 2016 Nov 14

     

    ·         Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

    Møller
    RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
    Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
    S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
    G, Cooper GM, Baulac S.

    Neurol Genet. 2016 Oct 31

     

    ·         p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

    Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.

    Oncogene. 2016 Oct 24

     

    ·         Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.

    Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

    Stem Cells Dev. 2016 Oct 17

     

    ·         Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

    Klein
    P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
    L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
    Butler-Browne G, Bastide B, Mouly V, Trollet C.

    Nucleic Acids Res. 2016 Aug 9

     

    ·         Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

    Vallerand
    D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
    Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
    Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
    Savina A, Decaudin D.

    PLoS One. 2016 Jul 7

     

    ·         Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.

    Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.

    Mol Neurodegener. 2016 Jun

     

    ·         Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

    Weckhuysen
    S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
    Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
    Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.

    Epilepsia 2016 May 13.

     

    ·         Control of neuronal synapse specification by a highly dedicated alternative splicing program

    Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.

    Science. 2016 May 12

     

    ·         GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.

    Guerenne
    L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
    Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
    Pla M, Fenaux P, Padua RA, Chomienne C, Krief P

    Hematol Oncol. 2016 Jan 27

     

    ·         Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
    Associated with the Upregulation of Wingless-Related Integration and
    Bone Morphogenetic Protein Signaling in Dark Agouti Rats.

    Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.

    Med Princ Pract. 2016

     

    ·         Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

    Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,

    Stem Cell Reports. 2015 Nov 11

     

    ·         From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

    Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,

    Biochim Biophys Acta. 2015 Oct 26.

     

    ·         Developmental clock compromises human twin model created by embryo splitting

    Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,

    Hum Reprod. 2015 Oct 21

     

    ·         MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
    and can be explored for human embryo reproductive competence assessment

    Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.

    Fertil Steril. 2015 Oct 9

     

    ·         Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
    provide insights into tumor biology and therapeutic leads.

    Auguste
    A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
    E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
    Galmiche L, Kalfa N, Veitia RA

    Hum Mol Genet. 2015 Sep 11.

     

    ·         TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

    De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.

    NAR. 2015 Aug

     

    ·         SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.

    Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.

    Gene, 2015 Jul.

     

    ·         DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

    Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.

    Blood. 2015 Apr 16

     

    ·         Disruption of SF3B1 results in deregulated expression and splicing of key genes
    and pathways in myelodysplastic syndrome hematopoietic stem and
    progenitor cells

    H
    Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
    Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
    Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
    Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
    1092–1103

     

    ·         Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

    Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.

    Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.

     

    ·         Expression of the potential therapeutic target CXXC5 in primary acute myeloid
    leukemia cells – high expression is associated with adverse prognosis as
    well as altered intracellular signaling and transcriptional regulation.

    Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.

    Oncotarget. 2014 Dec 26

     

    ·         Acquired resistance to endocrine treatments is associated to tumor-specific
    molecular changes in patient-derived luminal breast cancer xenografts.

    Cottu
    PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
    Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
    Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
    Roman-Roman S, Marangoni E.

    Clin Cancer Res. 2014 Aug 15;20(16):4314-25.

     

    ·         Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.

    Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.

    Cell Reports. 2014 May 10

     

    ·         Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

    Lopez-Mejia
    IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
    Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

    EMBO Rep., 2014 Mar 17

     

    ·         RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

    Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.

    Mol Cell. 2013 Dec

     

    ·         Sudemycin E influences alternative splicing and changes chromatin modifications.

    Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.

    Nucleic Acids Res. 2014 Mar 11.

     

    ·         A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

    Pesson
    M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
    Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.

    PLoS One. 2014 Feb 6.

     

    ·         A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
    application to the study of genes involved in the response to targeted
    anticancer therapies

    Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.

    Mol. Cancer, 2014 Jan.

     

    ·         Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.

    Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S

    PLoS One. 2013 Dec.

     

    ·         CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.

    Astori
    A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
    Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
    Lillehaug JR, Pendino F, Bruserud O

    Oncotarget, 2013 Aug.

     

    ·         BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
    of AML by targeting primitive LSK and progenitor cells.

    Beurlet
    S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
    Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
    Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
    West R, Fenaux P, Chomienne C, Padua RA.

    Blood. 2013 Aug

     

    ·         SF3B1 mutations are associated with alternative splicing in uveal melanoma.

    Furney
    SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
    S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
    R.

    Cancer Discov. 2013 Jul 16

     

    ·         Molecular characterization of a patient presumed to have prader-willi syndrome.

    Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.

    Clin Med Insights Case Rep. 2013 May 10.

     

    ·         Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.

    Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

    Cell Reprogram. 2013 May 10.

     

    ·         Genome
    wide array analysis indicates that an amyotrophic lateral sclerosis
    mutation of FUS causes an early increase of CAMK2N2 in vitro.

    Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.

    Biochim Biophys Acta. 2013 Mar

     

    ·         Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

    Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.

    Nucleic Acids Res. 2013 Feb 7.

     

    ·         hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

    Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.

    EMBO J. 2013 Feb 5. , DOI

     

    ·         Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

    Sonia
    Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
    Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
    Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
    Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
    Renato C. Monteiro, Pierre de la Grange, Richard Moreau

    J Hepatol. 2013 Jan 12. , DOI

     

    ·         The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.

    Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.

    EMBO Mol Med. 2013 Jan 9. , DOI

     

    ·         Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.

    Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.

    PLoS One. 2012;7(12):e51266. , DOI

     

    ·         TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.

    Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.

    Oncogene. 2012 Nov 5. , DOI

     

    ·         Argonaute proteins couple chromatin silencing to alternative splicing.

    Ameyar-Zazoua
    M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
    R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
    C, Batsché E, Harel-Bellan A.

    Nat Struct Mol Biol. 2012 Sep 9

     

    ·         Lipocalin
    2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
    downstream of NFAT1 to regulate breast cancer cell invasion.

    Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

    J Cell Sci. 2012 Jul 5.

     

    ·         A transcriptome signature of endothelial lymphatic cells coexists with
    the chronic oxidative stress signature in radiation-induced
    post-radiotherapy breast angiosarcomas.

    Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.

    Carcinogenesis. 2012 May 7.,

     

    ·         Sperm transcriptome profiling in oligozoospermia.

    Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.

    J Assist Reprod Genet. 2012 Jan;29(1):3-10

     

    ·         Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.

    Jia Y, Mu JC, Ackerman SL.

    Cell. 2012 Jan 20;148(1-2):296-308

     

    ·         Identification
    of novel androgen-regulated pathways and mRNA isoforms through
    genome-wide exon-specific profiling of the LNCaP transcriptome.

    Rajan
    P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
    K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
    Leung HY, Elliott DJ.

    PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14

     

    ·         Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

    Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

    Human Molecular Genetics 2011, Jun 30

     

    ·         Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

    Fugier
    C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
    V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
    P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
    Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
    D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
    Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

    Nat Med. 2011 May 29

     

    ·         Melanoma
    spheroids grown under neural crest cell conditions are highly plastic
    migratory/invasive tumor cells endowed with immunomodulator function.

    Ramgolam
    K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
    Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R

    PLoS One 2011;6(4):e18784

     

    ·         Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

    Saint-André V, Batsché E, Rachez C, Muchardt C.

    Nature Structural and Molecular Biology 2011, 18(3):337-44

     

    ·         Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

    Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

    Nat Struct Mol Biol. 2010 Aug 15

     

    ·         Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.

    Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.

    Cancer Research 2010 Apr 20.

     

    ·         Splicing factor and exon profiling across human tissues.

    de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.

    Nucleic Acids Research. 2010 Jan 27.

     

    ·         Exon-Based
    Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
    Exons Whose Expression Is Associated with Metastasis.

    Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.

    Cancer Research 2010 Jan 26.

     

    ·         Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

    El-Bchiri
    J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
    la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.

    PLoS ONE. 2008, 3(7):e2583.

     

    ·         Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

    Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.

    Mol Cell Biol. 2007, 27(20):7315-33.

     

    ·         A new advance in alternative splicing databases: from catalogue to
    detailed analysis of regulation of expression and function of human
    alternative splicing variants.

    de la Grange P, Dutertre M, Correa M, Auboeuf D.

    BMC Bioinformatics 2007, 8:180

     

    ·         ASEtrap: a biological method for speeding up the exploration of spliceomes.

    Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.

    Genome Res. 2006, 16(6):776-86.

     

    ·         FAST DB: a website resource for the study of the expression regulation of human gene products.

    de la Grange P, Dutertre M, Martin N, Auboeuf D.

    Nucleic Acids Research 2005, 33(13):4276-4284.

    PMI

    Eur J Hum Genet. 2022 Mar 11.

    Brain. 2022 Mar 17

     Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

    Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

    • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
      Maxime
      Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
      Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
      Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
      Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
      Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
      Fenaux, Lionel Ades, Nicolas Dulphy

      Nat Commun. 2023 Feb 03 / 36737440

    MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

    • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

      Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

      Immunology. 2024 Jul 2 / 38953295

    • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

      Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

      Immunology. 2024 Jul 2 / 38953295

    • Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer

      Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette

      J Exp Clin Cancer Res. 2024 Feb 27 / 38413979

    • Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

      Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

      Nucleic Acids Res. 2024 Feb 7 / 38324473

    • A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner

      Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele

      Cell Rep. Mar 28 / 36862556

    • BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance

      Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer

      Cancer Discov. 2023 Nov 1 / 37623817

    • Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression

      Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue

      J Invest Dermatol. 2023 Sep 20 / 37739336

    • Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

      David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall

      Cell Rep. 2023 Sep 13 / 37708024

    • Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

      Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz

      JHEP Rep. 2023 May 16 / 37520673

    • Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs

      Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm

      Front Mol Neurosci. 2023 May 5 / 37266374

    • Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity

      Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl

      Cell Mol Life Sci. 2023 May 15 / 37184603

    • Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology

      Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel

      Exp Dermatol. 2023 May 6 / 37148203

    • CDK12/13 promote splicing of proximal introns by enhancing the
      interaction between RNA polymerase II and the splicing factor SF3B1

      Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

      Nucleic Acids Res. 2023 Apr 7 / 37026485

    • CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

      Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

      Nucleic Acids Res. 2023 Apr 7 / 37026485

    • MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

      Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn

      Nat Commun. 2023 Apr 1 / 37005415

    • T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions

      Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros

      Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942

    • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
      Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas Dulphy

      Nat Commun. 2023 Feb 03 / 36737440

    • RELA tunes innate-like interferon I/III responses in human T cells
      Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas Manel

      J Exp Med. 2023 Feb 23 / 36820829

    • Integrative genetic analysis illuminates ALS heritability and identifies risk genes
      Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc Dupuis

      Nat Commun. 2023 May 1/ 36670122

    • Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
      Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca Amati

      Int J Mol Sci. 2023 Jan 6 / 36674633

    • Cortical wiring by synapse type-specific control of local protein synthesis
      Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar Marín

      Science. 2022 Nov 25 / 36423280

    • The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
      Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-Kourbali

      Br J Cancer. 2022 Dec 22 / 36550208

    • RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
      Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan Stamm

      Nucleic Acids Res. 2022 Dec 19 / 36533443

    • Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.

      Olivier Ariste, Pierre de la Grange, Reiner A Veitia

      Clin Genet. 2022 Nov 10 / PMID: 36353970

    • Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.

      Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger

      EMBO J. 2022 Sep 23 / PMID: 36149731

    • A conserved molecular template underlies color pattern diversity in estrildid finches.

      Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau

      Sci Adv. 2022 Sep 2 / PMID: 36044564

    • RNF213-associated urticarial lesions with hypercytokinemia

      Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
      Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
      Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
      De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
      Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
      Irina Giurgea

       J Allergy Clin Immunol. 2022 Jun 30  / PMID: 35780935

    • Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

      Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine

      Aging. 2022 May 4 / PMID: 35507806

    • Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

      Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm

      Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103

    • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients

      Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella

      Blood. 2022 Mar 24 / PMID: 34905599

      • Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

        Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin

        Brain. 2022 Mar 17 / PMID: 35298632

      • Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data

        Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet

        Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653

      • CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

        Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu

        Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489

      • Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia

      Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin

       Brain. 2022 Jan 4 / PMID: 34983064

      • The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
      Chiara Naro, Monica De Musso, Francesca Delle Monache, Valentina Panzeri, Pierre de la Grange, Claudio Sette
      J Exp Clin Cancer Res. 2021 Dec 20 / PMID: 34930366
      • Epithelial colonization by gut dendritic cells promotes their functional diversification

      Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil

      Immunity. December 14, 2021

      https://www.sciencedirect.com/science/article/pii/S1074761321004994

      • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients

      Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella

      Blood. 2021 Dec 14 / PMID: 34905599

      • BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

      Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua

      Int J Mol Sci. 2021 Sep 30 / PMID: 34638998

      • Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
      Daphné Krzisch, Nayara Guedes, Clémentine Boccon-Gibod, Marine Baron,
      Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
      Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
      Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
      Leukemia Organization) group
      Am J Hematol. 2021 Aug 31 / PMID: 34462944
      • Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
      Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour,
      Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
      Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
      Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
      Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
      Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
      Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
      Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
      Guido Kroemer, Jonathan G Pol
      J Exp Med. 2021 Oct 4 / PMID: 34495298
      • Genes coding for transcription factors involved in stem cell
        maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
        COPD bronchial epithelial progenitors.

      Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.

      Mol Biol Rep. 2021 Aug 26 / PMID: 34436724

      • Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.

      Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
      la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.

      Cereb Cortex. 2021 May 21 / PMID: 34023893

      • Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
      E El Khouri, J Ghoumid, D Haye, F Giuliano, L Drevillon, A
      Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
      Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
      Mol Psychiatry. 2021 Apr 19. / PMID: 33867523
      • Activation of Macrophages by Lysophosphatidic Acid through
        the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
        Sclerosis Pathogenesis.

      Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
      Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
      Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
      Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.

      Mol Neurobiol. 2021 Feb / PMID: 32974731

      ·         Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

      Emmanuel
      Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
      Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
      Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
      Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
      Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
      Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5

       

      ·         Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.

      Ben
      Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
      Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
      10.1007/s12015-021-10123-z.

       

      ·         Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
      with oligodendroglial hyperplasia in epilepsy (MOGHE)

      Thomas
      Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
      Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
      Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
      Blumcke, Stéphanie Baulac

      Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.

       

      ·         Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?

      Lerebours
      F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
      S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.

      J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.

       

      ·         Plasma microRNA signature in presymptomatic and symptomatic subjects with
      C9orf72-associated frontotemporal dementia and amyotrophic lateral
      sclerosis.

      Kmetzsch
      V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
      Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
      Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.

      J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.

       

      ·         Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

      Casulleras
      M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
      López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
      Moreau R, Arroyo V, Clària J.

      Sci Transl Med. 2020 Oct 21;12(566):eaax5135.

       

      ·         Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

      Chiot
      A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
      Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
      Boillée S.

      Nat Neurosci. 2020 Oct 19.

       

      ·         Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

      Bogdan
      Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
      Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos

      Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.

       

      ·         Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.

       

      Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli

      Cell Rep. 2020 Apr 14 / PMID: 32294449

       

      ·         Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.

      Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.

      Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019

       

      ·         Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.

      Romagnoli
      M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
      Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
      MA, Glukhova MA, Faraldo MM.

      Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552

       

      ·         ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.

      Gacem
      N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
      Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.

      Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5

       

      ·         Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.

      Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.

      Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117

       

      ·         An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

      Traoré
      M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
      Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
      Falcone S

      Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131

       

      ·         A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

      Lévesque
      S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
      EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
      Kroemer G, Pol JG

      Oncoimmunology. 2019 Sep 7;8(11):e1657375

       

      ·         SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.

      Leman
      R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
      Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S

      Bioinformatics. 2019 Oct 16. pii: btz784

       

      ·         Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

      Furlanis E, Traunmüller L, Fucile G, Scheiffele P.

      Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5

       

      ·         Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

      Baldassari
      S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
      C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
      M, Baulac S

      Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

       

      ·         Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

      Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S

      Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861

       

      ·         Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

      Sica
      V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
      Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
      Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
      Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

      Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

       

      ·         Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

      Liu
      P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
      Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
      Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
      Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
      Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

      Nat Commun. 2019 Apr 2;10(1):1486

       

      ·         Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

      Romagnoli
      M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
      Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
      Raymond K, Glukhova MA, Faraldo MM.

      Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6

       

      ·         Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
      differentiation-dependent metabolic responses to IFNG stimulation.

      Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.

      Cell Death Dis. 2019 Mar 20;10(4):277

       

      ·         Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.

      Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.

      Cell Rep. 2019 Mar 12;26(11):2929-2941

       

      ·         p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.

      Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.

      Breast Cancer Res. 2019 Jan 25;21(1):13

       

      ·         Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

      Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

      Sci Rep. 2019 Jan 28;9(1):792

       

      ·         Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.

      Daruich
      A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
      JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.

      Sci Adv. 2019 Jan 9;5(1):eaau9940

       

      ·         Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

      Domenech
      C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
      Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.

      Stem Cell Reports 2018, Nov 13;11(5):1075-1091

       

      ·         The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

      Tury
      S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
      V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
      Lallemand F, Marangoni E, Bièche I, Callens C.

      J Pathol. 2018 Jun 7

       

      ·         Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.

      Bruno,
      A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
      L, Rahimian, A, Lemoine, F, de la Grange, P,   Guégan, J, Bielle, F,
      Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
      Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
      Mokhtari, K, Hoang-Xuan, K, Alentorn, A.

      Neuro Oncol. 2018 Jul 5;20(8):1092-1100

       

      ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

      Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

      Sci Rep. 2017 Dec 14;7(1):17595.

       

      ·         Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

      Cifdaloz
      M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
      Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
      E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
      Megías D, Valcárcel J, Soengas MS.

      Nat Commun. 2017 Dec 21;8(1):2249.

       

      ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

      Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

      Sci Rep. 2017 Dec 14;7(1):17595

       

      ·         Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

      Glentis
      A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
      Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
      Plodinec M, Vignjevic DM.

      Nat Commun. 2017 Oct 13;8(1):924.

       

      ·         hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell

      Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.

      Nucleic Acids Res. 2017 Oct 3

      ·         Neurotrophic factors for motor neurons: an à la carte menu

      Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.

      Med Sci (Paris). 2017 Oct;33(10):835-839

       

      ·         Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.

      Grégoire
      Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
      Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
      Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
      Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
      Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
      Alexandra Martins, Dominique Vaur, Sophie Krieger.

      Eur J Hum Genet. 2017 Oct;25(10):1147-1154

       

      ·         Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
      and Sensitivity to the DNA Repair Inhibitor AsiDNA.

      Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.

      Cancer Res. 2017 Aug 15;77(16):4207-4216

       

      ·         Pre-therapy liver transcriptome landscape in Indian and French patients with severe
      alcoholic hepatitis and steroid responsiveness

      Shvetank
      Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
      Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
      Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
      Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
      Richard Moreau & Shiv K. Sarin.

      Scientific Reports 2017 Jul 28;7(1):6816

       

      ·         Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

      Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.

      Nucleic Acids Res. 2017 Jun 7

       

      ·         Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

      Boulay
      AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
      Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
      Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.

      Cell Discov. 2017 Mar 28

       

      ·         An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation

      Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.

      Developmental Cell 2017 Mar 24

       

      ·         Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

      Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

      Proc Natl Acad Sci U S A. 2017 Mar 7

       

      ·         Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

      Santo
      J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
      S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
      G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,

      Int J Obes (Lond). 2017

       

      ·         Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

      Weiss
      E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
      Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
      Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
      Lotersztajn S, Moreau R.,

      J Hepatol. 2016 Dec 28

       

      ·         Deregulation of pre-messenger RNA splicing and rare diseases.

      de la Grange P.

      Med Sci (Paris). 2016 Dec

       

      ·         Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.

      Mauger O, Lemoine F, Scheiffele P.,

      Neuron. 2016 Nov 21

       

      ·         Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
      progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.

      La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C

      Elife. 2016 Nov 15

       

      ·         Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
      Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
      Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
      Neuronal Cultures.

      Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C

      Mol Neurobiol. 2016 Nov 14

       

      ·         Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

      Møller
      RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
      Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
      S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
      G, Cooper GM, Baulac S.

      Neurol Genet. 2016 Oct 31

       

      ·         p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

      Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.

      Oncogene. 2016 Oct 24

       

      ·         Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.

      Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

      Stem Cells Dev. 2016 Oct 17

       

      ·         Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

      Klein
      P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
      L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
      Butler-Browne G, Bastide B, Mouly V, Trollet C.

      Nucleic Acids Res. 2016 Aug 9

       

      ·         Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

      Vallerand
      D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
      Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
      Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
      Savina A, Decaudin D.

      PLoS One. 2016 Jul 7

       

      ·         Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.

      Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.

      Mol Neurodegener. 2016 Jun

       

      ·         Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

      Weckhuysen
      S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
      Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
      Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.

      Epilepsia 2016 May 13.

       

      ·         Control of neuronal synapse specification by a highly dedicated alternative splicing program

      Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.

      Science. 2016 May 12

       

      ·         GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.

      Guerenne
      L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
      Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
      Pla M, Fenaux P, Padua RA, Chomienne C, Krief P

      Hematol Oncol. 2016 Jan 27

       

      ·         Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
      Associated with the Upregulation of Wingless-Related Integration and
      Bone Morphogenetic Protein Signaling in Dark Agouti Rats.

      Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.

      Med Princ Pract. 2016

       

      ·         Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

      Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,

      Stem Cell Reports. 2015 Nov 11

       

      ·         From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

      Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,

      Biochim Biophys Acta. 2015 Oct 26.

       

      ·         Developmental clock compromises human twin model created by embryo splitting

      Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,

      Hum Reprod. 2015 Oct 21

       

      ·         MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
      and can be explored for human embryo reproductive competence assessment

      Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.

      Fertil Steril. 2015 Oct 9

       

      ·         Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
      provide insights into tumor biology and therapeutic leads.

      Auguste
      A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
      E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
      Galmiche L, Kalfa N, Veitia RA

      Hum Mol Genet. 2015 Sep 11.

       

      ·         TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

      De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.

      NAR. 2015 Aug

       

      ·         SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.

      Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.

      Gene, 2015 Jul.

       

      ·         DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

      Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.

      Blood. 2015 Apr 16

       

      ·         Disruption of SF3B1 results in deregulated expression and splicing of key genes
      and pathways in myelodysplastic syndrome hematopoietic stem and
      progenitor cells

      H
      Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
      Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
      Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
      Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
      1092–1103

       

      ·         Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

      Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.

      Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.

       

      ·         Expression of the potential therapeutic target CXXC5 in primary acute myeloid
      leukemia cells – high expression is associated with adverse prognosis as
      well as altered intracellular signaling and transcriptional regulation.

      Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.

      Oncotarget. 2014 Dec 26

       

      ·         Acquired resistance to endocrine treatments is associated to tumor-specific
      molecular changes in patient-derived luminal breast cancer xenografts.

      Cottu
      PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
      Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
      Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
      Roman-Roman S, Marangoni E.

      Clin Cancer Res. 2014 Aug 15;20(16):4314-25.

       

      ·         Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.

      Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.

      Cell Reports. 2014 May 10

       

      ·         Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

      Lopez-Mejia
      IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
      Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

      EMBO Rep., 2014 Mar 17

       

      ·         RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

      Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.

      Mol Cell. 2013 Dec

       

      ·         Sudemycin E influences alternative splicing and changes chromatin modifications.

      Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.

      Nucleic Acids Res. 2014 Mar 11.

       

      ·         A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

      Pesson
      M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
      Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.

      PLoS One. 2014 Feb 6.

       

      ·         A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
      application to the study of genes involved in the response to targeted
      anticancer therapies

      Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.

      Mol. Cancer, 2014 Jan.

       

      ·         Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.

      Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S

      PLoS One. 2013 Dec.

       

      ·         CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.

      Astori
      A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
      Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
      Lillehaug JR, Pendino F, Bruserud O

      Oncotarget, 2013 Aug.

       

      ·         BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
      of AML by targeting primitive LSK and progenitor cells.

      Beurlet
      S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
      Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
      Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
      West R, Fenaux P, Chomienne C, Padua RA.

      Blood. 2013 Aug

       

      ·         SF3B1 mutations are associated with alternative splicing in uveal melanoma.

      Furney
      SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
      S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
      R.

      Cancer Discov. 2013 Jul 16

       

      ·         Molecular characterization of a patient presumed to have prader-willi syndrome.

      Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.

      Clin Med Insights Case Rep. 2013 May 10.

       

      ·         Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.

      Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

      Cell Reprogram. 2013 May 10.

       

      ·         Genome
      wide array analysis indicates that an amyotrophic lateral sclerosis
      mutation of FUS causes an early increase of CAMK2N2 in vitro.

      Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.

      Biochim Biophys Acta. 2013 Mar

       

      ·         Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

      Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.

      Nucleic Acids Res. 2013 Feb 7.

       

      ·         hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

      Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.

      EMBO J. 2013 Feb 5. , DOI

       

      ·         Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

      Sonia
      Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
      Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
      Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
      Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
      Renato C. Monteiro, Pierre de la Grange, Richard Moreau

      J Hepatol. 2013 Jan 12. , DOI

       

      ·         The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.

      Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.

      EMBO Mol Med. 2013 Jan 9. , DOI

       

      ·         Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.

      Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.

      PLoS One. 2012;7(12):e51266. , DOI

       

      ·         TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.

      Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.

      Oncogene. 2012 Nov 5. , DOI

       

      ·         Argonaute proteins couple chromatin silencing to alternative splicing.

      Ameyar-Zazoua
      M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
      R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
      C, Batsché E, Harel-Bellan A.

      Nat Struct Mol Biol. 2012 Sep 9

       

      ·         Lipocalin
      2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
      downstream of NFAT1 to regulate breast cancer cell invasion.

      Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

      J Cell Sci. 2012 Jul 5.

       

      ·         A transcriptome signature of endothelial lymphatic cells coexists with
      the chronic oxidative stress signature in radiation-induced
      post-radiotherapy breast angiosarcomas.

      Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.

      Carcinogenesis. 2012 May 7.,

       

      ·         Sperm transcriptome profiling in oligozoospermia.

      Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.

      J Assist Reprod Genet. 2012 Jan;29(1):3-10

       

      ·         Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.

      Jia Y, Mu JC, Ackerman SL.

      Cell. 2012 Jan 20;148(1-2):296-308

       

      ·         Identification
      of novel androgen-regulated pathways and mRNA isoforms through
      genome-wide exon-specific profiling of the LNCaP transcriptome.

      Rajan
      P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
      K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
      Leung HY, Elliott DJ.

      PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14

       

      ·         Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

      Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

      Human Molecular Genetics 2011, Jun 30

       

      ·         Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

      Fugier
      C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
      V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
      P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
      Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
      D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
      Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

      Nat Med. 2011 May 29

       

      ·         Melanoma
      spheroids grown under neural crest cell conditions are highly plastic
      migratory/invasive tumor cells endowed with immunomodulator function.

      Ramgolam
      K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
      Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R

      PLoS One 2011;6(4):e18784

       

      ·         Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

      Saint-André V, Batsché E, Rachez C, Muchardt C.

      Nature Structural and Molecular Biology 2011, 18(3):337-44

       

      ·         Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

      Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

      Nat Struct Mol Biol. 2010 Aug 15

       

      ·         Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.

      Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.

      Cancer Research 2010 Apr 20.

       

      ·         Splicing factor and exon profiling across human tissues.

      de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.

      Nucleic Acids Research. 2010 Jan 27.

       

      ·         Exon-Based
      Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
      Exons Whose Expression Is Associated with Metastasis.

      Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.

      Cancer Research 2010 Jan 26.

       

      ·         Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

      El-Bchiri
      J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
      la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.

      PLoS ONE. 2008, 3(7):e2583.

       

      ·         Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

      Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.

      Mol Cell Biol. 2007, 27(20):7315-33.

       

      ·         A new advance in alternative splicing databases: from catalogue to
      detailed analysis of regulation of expression and function of human
      alternative splicing variants.

      de la Grange P, Dutertre M, Correa M, Auboeuf D.

      BMC Bioinformatics 2007, 8:180

       

      ·         ASEtrap: a biological method for speeding up the exploration of spliceomes.

      Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.

      Genome Res. 2006, 16(6):776-86.

       

      ·         FAST DB: a website resource for the study of the expression regulation of human gene products.

      de la Grange P, Dutertre M, Martin N, Auboeuf D.

      Nucleic Acids Research 2005, 33(13):4276-4284.

      PMI

      Eur J Hum Genet. 2022 Mar 11.

      Brain. 2022 Mar 17

       Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

      Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

      • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
        Maxime
        Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
        Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
        Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
        Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
        Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
        Fenaux, Lionel Ades, Nicolas Dulphy

        Nat Commun. 2023 Feb 03 / 36737440

      MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

      • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

        Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

        Immunology. 2024 Jul 2 / 38953295

      • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

        Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

        Immunology. 2024 Jul 2 / 38953295

      • Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer

        Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette

        J Exp Clin Cancer Res. 2024 Feb 27 / 38413979

      • Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

        Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

        Nucleic Acids Res. 2024 Feb 7 / 38324473

      • A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner

        Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele

        Cell Rep. Mar 28 / 36862556

      • BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance

        Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer

        Cancer Discov. 2023 Nov 1 / 37623817

      • Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression

        Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue

        J Invest Dermatol. 2023 Sep 20 / 37739336

      • Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

        David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall

        Cell Rep. 2023 Sep 13 / 37708024

      • Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

        Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz

        JHEP Rep. 2023 May 16 / 37520673

      • Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs

        Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm

        Front Mol Neurosci. 2023 May 5 / 37266374

      • Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity

        Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl

        Cell Mol Life Sci. 2023 May 15 / 37184603

      • Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology

        Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel

        Exp Dermatol. 2023 May 6 / 37148203

      • CDK12/13 promote splicing of proximal introns by enhancing the
        interaction between RNA polymerase II and the splicing factor SF3B1

        Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

        Nucleic Acids Res. 2023 Apr 7 / 37026485

      • CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

        Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

        Nucleic Acids Res. 2023 Apr 7 / 37026485

      • MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

        Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn

        Nat Commun. 2023 Apr 1 / 37005415

      • T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions

        Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros

        Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942

      • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
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      • RELA tunes innate-like interferon I/III responses in human T cells
        Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas Manel

        J Exp Med. 2023 Feb 23 / 36820829

      • Integrative genetic analysis illuminates ALS heritability and identifies risk genes
        Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc Dupuis

        Nat Commun. 2023 May 1/ 36670122

      • Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
        Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca Amati

        Int J Mol Sci. 2023 Jan 6 / 36674633

      • Cortical wiring by synapse type-specific control of local protein synthesis
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        Science. 2022 Nov 25 / 36423280

      • The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
        Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-Kourbali

        Br J Cancer. 2022 Dec 22 / 36550208

      • RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
        Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan Stamm

        Nucleic Acids Res. 2022 Dec 19 / 36533443

      • Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.

        Olivier Ariste, Pierre de la Grange, Reiner A Veitia

        Clin Genet. 2022 Nov 10 / PMID: 36353970

      • Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.

        Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger

        EMBO J. 2022 Sep 23 / PMID: 36149731

      • A conserved molecular template underlies color pattern diversity in estrildid finches.

        Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau

        Sci Adv. 2022 Sep 2 / PMID: 36044564

      • RNF213-associated urticarial lesions with hypercytokinemia

        Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
        Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
        Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
        De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
        Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
        Irina Giurgea

         J Allergy Clin Immunol. 2022 Jun 30  / PMID: 35780935

      • Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

        Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine

        Aging. 2022 May 4 / PMID: 35507806

      • Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

        Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm

        Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103

      • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients

        Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella

        Blood. 2022 Mar 24 / PMID: 34905599

        • Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

          Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin

          Brain. 2022 Mar 17 / PMID: 35298632

        • Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data

          Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet

          Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653

        • CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

          Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu

          Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489

        • Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia

        Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin

         Brain. 2022 Jan 4 / PMID: 34983064

        • The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
        Chiara Naro, Monica De Musso, Francesca Delle Monache, Valentina Panzeri, Pierre de la Grange, Claudio Sette
        J Exp Clin Cancer Res. 2021 Dec 20 / PMID: 34930366
        • Epithelial colonization by gut dendritic cells promotes their functional diversification

        Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil

        Immunity. December 14, 2021

        https://www.sciencedirect.com/science/article/pii/S1074761321004994

        • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients

        Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella

        Blood. 2021 Dec 14 / PMID: 34905599

        • BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

        Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua

        Int J Mol Sci. 2021 Sep 30 / PMID: 34638998

        • Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
        Daphné Krzisch, Nayara Guedes, Clémentine Boccon-Gibod, Marine Baron,
        Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
        Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
        Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
        Leukemia Organization) group
        Am J Hematol. 2021 Aug 31 / PMID: 34462944
        • Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
        Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour,
        Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
        Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
        Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
        Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
        Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
        Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
        Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
        Guido Kroemer, Jonathan G Pol
        J Exp Med. 2021 Oct 4 / PMID: 34495298
        • Genes coding for transcription factors involved in stem cell
          maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
          COPD bronchial epithelial progenitors.

        Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.

        Mol Biol Rep. 2021 Aug 26 / PMID: 34436724

        • Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.

        Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
        la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.

        Cereb Cortex. 2021 May 21 / PMID: 34023893

        • Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
        E El Khouri, J Ghoumid, D Haye, F Giuliano, L Drevillon, A
        Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
        Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
        Mol Psychiatry. 2021 Apr 19. / PMID: 33867523
        • Activation of Macrophages by Lysophosphatidic Acid through
          the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
          Sclerosis Pathogenesis.

        Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
        Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
        Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
        Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.

        Mol Neurobiol. 2021 Feb / PMID: 32974731

        ·         Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

        Emmanuel
        Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
        Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
        Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
        Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
        Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
        Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5

         

        ·         Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.

        Ben
        Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
        Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
        10.1007/s12015-021-10123-z.

         

        ·         Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
        with oligodendroglial hyperplasia in epilepsy (MOGHE)

        Thomas
        Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
        Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
        Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
        Blumcke, Stéphanie Baulac

        Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.

         

        ·         Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?

        Lerebours
        F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
        S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.

        J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.

         

        ·         Plasma microRNA signature in presymptomatic and symptomatic subjects with
        C9orf72-associated frontotemporal dementia and amyotrophic lateral
        sclerosis.

        Kmetzsch
        V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
        Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
        Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.

        J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.

         

        ·         Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

        Casulleras
        M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
        López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
        Moreau R, Arroyo V, Clària J.

        Sci Transl Med. 2020 Oct 21;12(566):eaax5135.

         

        ·         Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

        Chiot
        A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
        Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
        Boillée S.

        Nat Neurosci. 2020 Oct 19.

         

        ·         Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

        Bogdan
        Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
        Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos

        Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.

         

        ·         Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.

         

        Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli

        Cell Rep. 2020 Apr 14 / PMID: 32294449

         

        ·         Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.

        Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.

        Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019

         

        ·         Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.

        Romagnoli
        M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
        Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
        MA, Glukhova MA, Faraldo MM.

        Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552

         

        ·         ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.

        Gacem
        N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
        Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.

        Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5

         

        ·         Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.

        Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.

        Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117

         

        ·         An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

        Traoré
        M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
        Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
        Falcone S

        Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131

         

        ·         A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

        Lévesque
        S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
        EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
        Kroemer G, Pol JG

        Oncoimmunology. 2019 Sep 7;8(11):e1657375

         

        ·         SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.

        Leman
        R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
        Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S

        Bioinformatics. 2019 Oct 16. pii: btz784

         

        ·         Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

        Furlanis E, Traunmüller L, Fucile G, Scheiffele P.

        Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5

         

        ·         Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

        Baldassari
        S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
        C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
        M, Baulac S

        Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

         

        ·         Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

        Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S

        Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861

         

        ·         Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

        Sica
        V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
        Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
        Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
        Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

        Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

         

        ·         Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

        Liu
        P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
        Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
        Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
        Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
        Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

        Nat Commun. 2019 Apr 2;10(1):1486

         

        ·         Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

        Romagnoli
        M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
        Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
        Raymond K, Glukhova MA, Faraldo MM.

        Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6

         

        ·         Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
        differentiation-dependent metabolic responses to IFNG stimulation.

        Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.

        Cell Death Dis. 2019 Mar 20;10(4):277

         

        ·         Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.

        Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.

        Cell Rep. 2019 Mar 12;26(11):2929-2941

         

        ·         p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.

        Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.

        Breast Cancer Res. 2019 Jan 25;21(1):13

         

        ·         Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

        Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

        Sci Rep. 2019 Jan 28;9(1):792

         

        ·         Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.

        Daruich
        A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
        JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.

        Sci Adv. 2019 Jan 9;5(1):eaau9940

         

        ·         Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

        Domenech
        C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
        Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.

        Stem Cell Reports 2018, Nov 13;11(5):1075-1091

         

        ·         The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

        Tury
        S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
        V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
        Lallemand F, Marangoni E, Bièche I, Callens C.

        J Pathol. 2018 Jun 7

         

        ·         Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.

        Bruno,
        A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
        L, Rahimian, A, Lemoine, F, de la Grange, P,   Guégan, J, Bielle, F,
        Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
        Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
        Mokhtari, K, Hoang-Xuan, K, Alentorn, A.

        Neuro Oncol. 2018 Jul 5;20(8):1092-1100

         

        ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

        Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

        Sci Rep. 2017 Dec 14;7(1):17595.

         

        ·         Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

        Cifdaloz
        M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
        Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
        E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
        Megías D, Valcárcel J, Soengas MS.

        Nat Commun. 2017 Dec 21;8(1):2249.

         

        ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

        Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

        Sci Rep. 2017 Dec 14;7(1):17595

         

        ·         Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

        Glentis
        A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
        Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
        Plodinec M, Vignjevic DM.

        Nat Commun. 2017 Oct 13;8(1):924.

         

        ·         hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell

        Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.

        Nucleic Acids Res. 2017 Oct 3

        ·         Neurotrophic factors for motor neurons: an à la carte menu

        Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.

        Med Sci (Paris). 2017 Oct;33(10):835-839

         

        ·         Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.

        Grégoire
        Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
        Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
        Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
        Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
        Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
        Alexandra Martins, Dominique Vaur, Sophie Krieger.

        Eur J Hum Genet. 2017 Oct;25(10):1147-1154

         

        ·         Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
        and Sensitivity to the DNA Repair Inhibitor AsiDNA.

        Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.

        Cancer Res. 2017 Aug 15;77(16):4207-4216

         

        ·         Pre-therapy liver transcriptome landscape in Indian and French patients with severe
        alcoholic hepatitis and steroid responsiveness

        Shvetank
        Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
        Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
        Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
        Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
        Richard Moreau & Shiv K. Sarin.

        Scientific Reports 2017 Jul 28;7(1):6816

         

        ·         Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

        Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.

        Nucleic Acids Res. 2017 Jun 7

         

        ·         Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

        Boulay
        AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
        Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
        Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.

        Cell Discov. 2017 Mar 28

         

        ·         An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation

        Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.

        Developmental Cell 2017 Mar 24

         

        ·         Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

        Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

        Proc Natl Acad Sci U S A. 2017 Mar 7

         

        ·         Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

        Santo
        J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
        S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
        G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,

        Int J Obes (Lond). 2017

         

        ·         Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

        Weiss
        E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
        Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
        Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
        Lotersztajn S, Moreau R.,

        J Hepatol. 2016 Dec 28

         

        ·         Deregulation of pre-messenger RNA splicing and rare diseases.

        de la Grange P.

        Med Sci (Paris). 2016 Dec

         

        ·         Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.

        Mauger O, Lemoine F, Scheiffele P.,

        Neuron. 2016 Nov 21

         

        ·         Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
        progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.

        La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C

        Elife. 2016 Nov 15

         

        ·         Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
        Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
        Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
        Neuronal Cultures.

        Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C

        Mol Neurobiol. 2016 Nov 14

         

        ·         Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

        Møller
        RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
        Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
        S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
        G, Cooper GM, Baulac S.

        Neurol Genet. 2016 Oct 31

         

        ·         p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

        Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.

        Oncogene. 2016 Oct 24

         

        ·         Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.

        Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

        Stem Cells Dev. 2016 Oct 17

         

        ·         Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

        Klein
        P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
        L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
        Butler-Browne G, Bastide B, Mouly V, Trollet C.

        Nucleic Acids Res. 2016 Aug 9

         

        ·         Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

        Vallerand
        D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
        Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
        Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
        Savina A, Decaudin D.

        PLoS One. 2016 Jul 7

         

        ·         Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.

        Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.

        Mol Neurodegener. 2016 Jun

         

        ·         Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

        Weckhuysen
        S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
        Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
        Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.

        Epilepsia 2016 May 13.

         

        ·         Control of neuronal synapse specification by a highly dedicated alternative splicing program

        Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.

        Science. 2016 May 12

         

        ·         GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.

        Guerenne
        L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
        Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
        Pla M, Fenaux P, Padua RA, Chomienne C, Krief P

        Hematol Oncol. 2016 Jan 27

         

        ·         Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
        Associated with the Upregulation of Wingless-Related Integration and
        Bone Morphogenetic Protein Signaling in Dark Agouti Rats.

        Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.

        Med Princ Pract. 2016

         

        ·         Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

        Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,

        Stem Cell Reports. 2015 Nov 11

         

        ·         From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

        Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,

        Biochim Biophys Acta. 2015 Oct 26.

         

        ·         Developmental clock compromises human twin model created by embryo splitting

        Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,

        Hum Reprod. 2015 Oct 21

         

        ·         MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
        and can be explored for human embryo reproductive competence assessment

        Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.

        Fertil Steril. 2015 Oct 9

         

        ·         Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
        provide insights into tumor biology and therapeutic leads.

        Auguste
        A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
        E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
        Galmiche L, Kalfa N, Veitia RA

        Hum Mol Genet. 2015 Sep 11.

         

        ·         TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

        De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.

        NAR. 2015 Aug

         

        ·         SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.

        Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.

        Gene, 2015 Jul.

         

        ·         DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

        Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.

        Blood. 2015 Apr 16

         

        ·         Disruption of SF3B1 results in deregulated expression and splicing of key genes
        and pathways in myelodysplastic syndrome hematopoietic stem and
        progenitor cells

        H
        Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
        Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
        Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
        Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
        1092–1103

         

        ·         Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

        Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.

        Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.

         

        ·         Expression of the potential therapeutic target CXXC5 in primary acute myeloid
        leukemia cells – high expression is associated with adverse prognosis as
        well as altered intracellular signaling and transcriptional regulation.

        Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.

        Oncotarget. 2014 Dec 26

         

        ·         Acquired resistance to endocrine treatments is associated to tumor-specific
        molecular changes in patient-derived luminal breast cancer xenografts.

        Cottu
        PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
        Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
        Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
        Roman-Roman S, Marangoni E.

        Clin Cancer Res. 2014 Aug 15;20(16):4314-25.

         

        ·         Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.

        Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.

        Cell Reports. 2014 May 10

         

        ·         Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

        Lopez-Mejia
        IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
        Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

        EMBO Rep., 2014 Mar 17

         

        ·         RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

        Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.

        Mol Cell. 2013 Dec

         

        ·         Sudemycin E influences alternative splicing and changes chromatin modifications.

        Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.

        Nucleic Acids Res. 2014 Mar 11.

         

        ·         A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

        Pesson
        M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
        Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.

        PLoS One. 2014 Feb 6.

         

        ·         A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
        application to the study of genes involved in the response to targeted
        anticancer therapies

        Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.

        Mol. Cancer, 2014 Jan.

         

        ·         Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.

        Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S

        PLoS One. 2013 Dec.

         

        ·         CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.

        Astori
        A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
        Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
        Lillehaug JR, Pendino F, Bruserud O

        Oncotarget, 2013 Aug.

         

        ·         BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
        of AML by targeting primitive LSK and progenitor cells.

        Beurlet
        S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
        Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
        Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
        West R, Fenaux P, Chomienne C, Padua RA.

        Blood. 2013 Aug

         

        ·         SF3B1 mutations are associated with alternative splicing in uveal melanoma.

        Furney
        SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
        S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
        R.

        Cancer Discov. 2013 Jul 16

         

        ·         Molecular characterization of a patient presumed to have prader-willi syndrome.

        Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.

        Clin Med Insights Case Rep. 2013 May 10.

         

        ·         Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.

        Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

        Cell Reprogram. 2013 May 10.

         

        ·         Genome
        wide array analysis indicates that an amyotrophic lateral sclerosis
        mutation of FUS causes an early increase of CAMK2N2 in vitro.

        Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.

        Biochim Biophys Acta. 2013 Mar

         

        ·         Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

        Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.

        Nucleic Acids Res. 2013 Feb 7.

         

        ·         hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

        Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.

        EMBO J. 2013 Feb 5. , DOI

         

        ·         Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

        Sonia
        Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
        Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
        Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
        Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
        Renato C. Monteiro, Pierre de la Grange, Richard Moreau

        J Hepatol. 2013 Jan 12. , DOI

         

        ·         The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.

        Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.

        EMBO Mol Med. 2013 Jan 9. , DOI

         

        ·         Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.

        Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.

        PLoS One. 2012;7(12):e51266. , DOI

         

        ·         TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.

        Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.

        Oncogene. 2012 Nov 5. , DOI

         

        ·         Argonaute proteins couple chromatin silencing to alternative splicing.

        Ameyar-Zazoua
        M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
        R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
        C, Batsché E, Harel-Bellan A.

        Nat Struct Mol Biol. 2012 Sep 9

         

        ·         Lipocalin
        2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
        downstream of NFAT1 to regulate breast cancer cell invasion.

        Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

        J Cell Sci. 2012 Jul 5.

         

        ·         A transcriptome signature of endothelial lymphatic cells coexists with
        the chronic oxidative stress signature in radiation-induced
        post-radiotherapy breast angiosarcomas.

        Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.

        Carcinogenesis. 2012 May 7.,

         

        ·         Sperm transcriptome profiling in oligozoospermia.

        Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.

        J Assist Reprod Genet. 2012 Jan;29(1):3-10

         

        ·         Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.

        Jia Y, Mu JC, Ackerman SL.

        Cell. 2012 Jan 20;148(1-2):296-308

         

        ·         Identification
        of novel androgen-regulated pathways and mRNA isoforms through
        genome-wide exon-specific profiling of the LNCaP transcriptome.

        Rajan
        P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
        K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
        Leung HY, Elliott DJ.

        PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14

         

        ·         Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

        Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

        Human Molecular Genetics 2011, Jun 30

         

        ·         Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

        Fugier
        C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
        V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
        P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
        Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
        D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
        Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

        Nat Med. 2011 May 29

         

        ·         Melanoma
        spheroids grown under neural crest cell conditions are highly plastic
        migratory/invasive tumor cells endowed with immunomodulator function.

        Ramgolam
        K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
        Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R

        PLoS One 2011;6(4):e18784

         

        ·         Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

        Saint-André V, Batsché E, Rachez C, Muchardt C.

        Nature Structural and Molecular Biology 2011, 18(3):337-44

         

        ·         Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

        Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

        Nat Struct Mol Biol. 2010 Aug 15

         

        ·         Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.

        Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.

        Cancer Research 2010 Apr 20.

         

        ·         Splicing factor and exon profiling across human tissues.

        de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.

        Nucleic Acids Research. 2010 Jan 27.

         

        ·         Exon-Based
        Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
        Exons Whose Expression Is Associated with Metastasis.

        Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.

        Cancer Research 2010 Jan 26.

         

        ·         Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

        El-Bchiri
        J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
        la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.

        PLoS ONE. 2008, 3(7):e2583.

         

        ·         Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

        Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.

        Mol Cell Biol. 2007, 27(20):7315-33.

         

        ·         A new advance in alternative splicing databases: from catalogue to
        detailed analysis of regulation of expression and function of human
        alternative splicing variants.

        de la Grange P, Dutertre M, Correa M, Auboeuf D.

        BMC Bioinformatics 2007, 8:180

         

        ·         ASEtrap: a biological method for speeding up the exploration of spliceomes.

        Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.

        Genome Res. 2006, 16(6):776-86.

         

        ·         FAST DB: a website resource for the study of the expression regulation of human gene products.

        de la Grange P, Dutertre M, Martin N, Auboeuf D.

        Nucleic Acids Research 2005, 33(13):4276-4284.

        PMI

        Eur J Hum Genet. 2022 Mar 11.

        Brain. 2022 Mar 17

         Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

        Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

        • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
          Maxime
          Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
          Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
          Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
          Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
          Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
          Fenaux, Lionel Ades, Nicolas Dulphy

          Nat Commun. 2023 Feb 03 / 36737440

        MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

        • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

          Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

          Immunology. 2024 Jul 2 / 38953295

        • Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer

          Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina

          Immunology. 2024 Jul 2 / 38953295

        • Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer

          Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette

          J Exp Clin Cancer Res. 2024 Feb 27 / 38413979

        • Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development

          Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette

          Nucleic Acids Res. 2024 Feb 7 / 38324473

        • A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner

          Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele

          Cell Rep. Mar 28 / 36862556

        • BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance

          Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer

          Cancer Discov. 2023 Nov 1 / 37623817

        • Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression

          Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue

          J Invest Dermatol. 2023 Sep 20 / 37739336

        • Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma

          David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall

          Cell Rep. 2023 Sep 13 / 37708024

        • Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration

          Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz

          JHEP Rep. 2023 May 16 / 37520673

        • Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs

          Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm

          Front Mol Neurosci. 2023 May 5 / 37266374

        • Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity

          Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl

          Cell Mol Life Sci. 2023 May 15 / 37184603

        • Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology

          Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel

          Exp Dermatol. 2023 May 6 / 37148203

        • CDK12/13 promote splicing of proximal introns by enhancing the
          interaction between RNA polymerase II and the splicing factor SF3B1

          Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

          Nucleic Acids Res. 2023 Apr 7 / 37026485

        • CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1

          Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette

          Nucleic Acids Res. 2023 Apr 7 / 37026485

        • MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

          Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn

          Nat Commun. 2023 Apr 1 / 37005415

        • T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions

          Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros

          Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942

        • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
          Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas Dulphy

          Nat Commun. 2023 Feb 03 / 36737440

        • RELA tunes innate-like interferon I/III responses in human T cells
          Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas Manel

          J Exp Med. 2023 Feb 23 / 36820829

        • Integrative genetic analysis illuminates ALS heritability and identifies risk genes
          Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc Dupuis

          Nat Commun. 2023 May 1/ 36670122

        • Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
          Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca Amati

          Int J Mol Sci. 2023 Jan 6 / 36674633

        • Cortical wiring by synapse type-specific control of local protein synthesis
          Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar Marín

          Science. 2022 Nov 25 / 36423280

        • The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
          Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-Kourbali

          Br J Cancer. 2022 Dec 22 / 36550208

        • RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
          Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan Stamm

          Nucleic Acids Res. 2022 Dec 19 / 36533443

        • Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.

          Olivier Ariste, Pierre de la Grange, Reiner A Veitia

          Clin Genet. 2022 Nov 10 / PMID: 36353970

        • Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.

          Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger

          EMBO J. 2022 Sep 23 / PMID: 36149731

        • A conserved molecular template underlies color pattern diversity in estrildid finches.

          Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau

          Sci Adv. 2022 Sep 2 / PMID: 36044564

        • RNF213-associated urticarial lesions with hypercytokinemia

          Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
          Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
          Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
          De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
          Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
          Irina Giurgea

           J Allergy Clin Immunol. 2022 Jun 30  / PMID: 35780935

        • Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

          Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine

          Aging. 2022 May 4 / PMID: 35507806

        • Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

          Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm

          Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103

        • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients

          Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella

          Blood. 2022 Mar 24 / PMID: 34905599

          • Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway

            Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin

            Brain. 2022 Mar 17 / PMID: 35298632

          • Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data

            Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet

            Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653

          • CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1

            Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu

            Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489

          • Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia

          Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin

           Brain. 2022 Jan 4 / PMID: 34983064

          • The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
          Chiara Naro, Monica De Musso, Francesca Delle Monache, Valentina Panzeri, Pierre de la Grange, Claudio Sette
          J Exp Clin Cancer Res. 2021 Dec 20 / PMID: 34930366
          • Epithelial colonization by gut dendritic cells promotes their functional diversification

          Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil

          Immunity. December 14, 2021

          https://www.sciencedirect.com/science/article/pii/S1074761321004994

          • Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients

          Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella

          Blood. 2021 Dec 14 / PMID: 34905599

          • BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome

          Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua

          Int J Mol Sci. 2021 Sep 30 / PMID: 34638998

          • Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
          Daphné Krzisch, Nayara Guedes, Clémentine Boccon-Gibod, Marine Baron,
          Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
          Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
          Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
          Leukemia Organization) group
          Am J Hematol. 2021 Aug 31 / PMID: 34462944
          • Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
          Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour,
          Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
          Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
          Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
          Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
          Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
          Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
          Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
          Guido Kroemer, Jonathan G Pol
          J Exp Med. 2021 Oct 4 / PMID: 34495298
          • Genes coding for transcription factors involved in stem cell
            maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
            COPD bronchial epithelial progenitors.

          Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.

          Mol Biol Rep. 2021 Aug 26 / PMID: 34436724

          • Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.

          Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
          la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.

          Cereb Cortex. 2021 May 21 / PMID: 34023893

          • Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
          E El Khouri, J Ghoumid, D Haye, F Giuliano, L Drevillon, A
          Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
          Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
          Mol Psychiatry. 2021 Apr 19. / PMID: 33867523
          • Activation of Macrophages by Lysophosphatidic Acid through
            the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
            Sclerosis Pathogenesis.

          Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
          Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
          Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
          Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.

          Mol Neurobiol. 2021 Feb / PMID: 32974731

          ·         Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

          Emmanuel
          Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
          Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
          Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
          Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
          Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
          Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5

           

          ·         Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.

          Ben
          Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
          Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
          10.1007/s12015-021-10123-z.

           

          ·         Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
          with oligodendroglial hyperplasia in epilepsy (MOGHE)

          Thomas
          Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
          Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
          Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
          Blumcke, Stéphanie Baulac

          Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.

           

          ·         Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?

          Lerebours
          F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
          S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.

          J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.

           

          ·         Plasma microRNA signature in presymptomatic and symptomatic subjects with
          C9orf72-associated frontotemporal dementia and amyotrophic lateral
          sclerosis.

          Kmetzsch
          V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
          Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
          Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.

          J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.

           

          ·         Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

          Casulleras
          M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
          López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
          Moreau R, Arroyo V, Clària J.

          Sci Transl Med. 2020 Oct 21;12(566):eaax5135.

           

          ·         Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

          Chiot
          A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
          Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
          Boillée S.

          Nat Neurosci. 2020 Oct 19.

           

          ·         Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

          Bogdan
          Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
          Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos

          Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.

           

          ·         Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.

           

          Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli

          Cell Rep. 2020 Apr 14 / PMID: 32294449

           

          ·         Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.

          Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.

          Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019

           

          ·         Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.

          Romagnoli
          M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
          Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
          MA, Glukhova MA, Faraldo MM.

          Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552

           

          ·         ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.

          Gacem
          N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
          Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.

          Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5

           

          ·         Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.

          Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.

          Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117

           

          ·         An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

          Traoré
          M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
          Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
          Falcone S

          Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131

           

          ·         A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

          Lévesque
          S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
          EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
          Kroemer G, Pol JG

          Oncoimmunology. 2019 Sep 7;8(11):e1657375

           

          ·         SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.

          Leman
          R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
          Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S

          Bioinformatics. 2019 Oct 16. pii: btz784

           

          ·         Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

          Furlanis E, Traunmüller L, Fucile G, Scheiffele P.

          Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5

           

          ·         Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

          Baldassari
          S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
          C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
          M, Baulac S

          Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

           

          ·         Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

          Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S

          Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861

           

          ·         Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

          Sica
          V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
          Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
          Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
          Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

          Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

           

          ·         Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

          Liu
          P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
          Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
          Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
          Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
          Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

          Nat Commun. 2019 Apr 2;10(1):1486

           

          ·         Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

          Romagnoli
          M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
          Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
          Raymond K, Glukhova MA, Faraldo MM.

          Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6

           

          ·         Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
          differentiation-dependent metabolic responses to IFNG stimulation.

          Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.

          Cell Death Dis. 2019 Mar 20;10(4):277

           

          ·         Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.

          Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.

          Cell Rep. 2019 Mar 12;26(11):2929-2941

           

          ·         p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.

          Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.

          Breast Cancer Res. 2019 Jan 25;21(1):13

           

          ·         Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

          Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

          Sci Rep. 2019 Jan 28;9(1):792

           

          ·         Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.

          Daruich
          A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
          JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.

          Sci Adv. 2019 Jan 9;5(1):eaau9940

           

          ·         Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

          Domenech
          C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
          Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.

          Stem Cell Reports 2018, Nov 13;11(5):1075-1091

           

          ·         The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

          Tury
          S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
          V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
          Lallemand F, Marangoni E, Bièche I, Callens C.

          J Pathol. 2018 Jun 7

           

          ·         Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.

          Bruno,
          A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
          L, Rahimian, A, Lemoine, F, de la Grange, P,   Guégan, J, Bielle, F,
          Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
          Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
          Mokhtari, K, Hoang-Xuan, K, Alentorn, A.

          Neuro Oncol. 2018 Jul 5;20(8):1092-1100

           

          ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

          Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

          Sci Rep. 2017 Dec 14;7(1):17595.

           

          ·         Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

          Cifdaloz
          M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
          Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
          E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
          Megías D, Valcárcel J, Soengas MS.

          Nat Commun. 2017 Dec 21;8(1):2249.

           

          ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

          Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

          Sci Rep. 2017 Dec 14;7(1):17595

           

          ·         Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

          Glentis
          A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
          Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
          Plodinec M, Vignjevic DM.

          Nat Commun. 2017 Oct 13;8(1):924.

           

          ·         hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell

          Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.

          Nucleic Acids Res. 2017 Oct 3

          ·         Neurotrophic factors for motor neurons: an à la carte menu

          Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.

          Med Sci (Paris). 2017 Oct;33(10):835-839

           

          ·         Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.

          Grégoire
          Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
          Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
          Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
          Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
          Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
          Alexandra Martins, Dominique Vaur, Sophie Krieger.

          Eur J Hum Genet. 2017 Oct;25(10):1147-1154

           

          ·         Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
          and Sensitivity to the DNA Repair Inhibitor AsiDNA.

          Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.

          Cancer Res. 2017 Aug 15;77(16):4207-4216

           

          ·         Pre-therapy liver transcriptome landscape in Indian and French patients with severe
          alcoholic hepatitis and steroid responsiveness

          Shvetank
          Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
          Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
          Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
          Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
          Richard Moreau & Shiv K. Sarin.

          Scientific Reports 2017 Jul 28;7(1):6816

           

          ·         Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

          Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.

          Nucleic Acids Res. 2017 Jun 7

           

          ·         Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

          Boulay
          AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
          Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
          Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.

          Cell Discov. 2017 Mar 28

           

          ·         An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation

          Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.

          Developmental Cell 2017 Mar 24

           

          ·         Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

          Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

          Proc Natl Acad Sci U S A. 2017 Mar 7

           

          ·         Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

          Santo
          J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
          S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
          G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,

          Int J Obes (Lond). 2017

           

          ·         Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

          Weiss
          E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
          Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
          Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
          Lotersztajn S, Moreau R.,

          J Hepatol. 2016 Dec 28

           

          ·         Deregulation of pre-messenger RNA splicing and rare diseases.

          de la Grange P.

          Med Sci (Paris). 2016 Dec

           

          ·         Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.

          Mauger O, Lemoine F, Scheiffele P.,

          Neuron. 2016 Nov 21

           

          ·         Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
          progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.

          La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C

          Elife. 2016 Nov 15

           

          ·         Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
          Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
          Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
          Neuronal Cultures.

          Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C

          Mol Neurobiol. 2016 Nov 14

           

          ·         Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

          Møller
          RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
          Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
          S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
          G, Cooper GM, Baulac S.

          Neurol Genet. 2016 Oct 31

           

          ·         p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

          Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.

          Oncogene. 2016 Oct 24

           

          ·         Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.

          Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

          Stem Cells Dev. 2016 Oct 17

           

          ·         Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

          Klein
          P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
          L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
          Butler-Browne G, Bastide B, Mouly V, Trollet C.

          Nucleic Acids Res. 2016 Aug 9

           

          ·         Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

          Vallerand
          D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
          Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
          Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
          Savina A, Decaudin D.

          PLoS One. 2016 Jul 7

           

          ·         Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.

          Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.

          Mol Neurodegener. 2016 Jun

           

          ·         Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

          Weckhuysen
          S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
          Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
          Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.

          Epilepsia 2016 May 13.

           

          ·         Control of neuronal synapse specification by a highly dedicated alternative splicing program

          Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.

          Science. 2016 May 12

           

          ·         GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.

          Guerenne
          L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
          Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
          Pla M, Fenaux P, Padua RA, Chomienne C, Krief P

          Hematol Oncol. 2016 Jan 27

           

          ·         Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
          Associated with the Upregulation of Wingless-Related Integration and
          Bone Morphogenetic Protein Signaling in Dark Agouti Rats.

          Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.

          Med Princ Pract. 2016

           

          ·         Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

          Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,

          Stem Cell Reports. 2015 Nov 11

           

          ·         From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

          Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,

          Biochim Biophys Acta. 2015 Oct 26.

           

          ·         Developmental clock compromises human twin model created by embryo splitting

          Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,

          Hum Reprod. 2015 Oct 21

           

          ·         MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
          and can be explored for human embryo reproductive competence assessment

          Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.

          Fertil Steril. 2015 Oct 9

           

          ·         Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
          provide insights into tumor biology and therapeutic leads.

          Auguste
          A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
          E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
          Galmiche L, Kalfa N, Veitia RA

          Hum Mol Genet. 2015 Sep 11.

           

          ·         TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

          De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.

          NAR. 2015 Aug

           

          ·         SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.

          Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.

          Gene, 2015 Jul.

           

          ·         DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

          Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.

          Blood. 2015 Apr 16

           

          ·         Disruption of SF3B1 results in deregulated expression and splicing of key genes
          and pathways in myelodysplastic syndrome hematopoietic stem and
          progenitor cells

          H
          Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
          Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
          Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
          Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
          1092–1103

           

          ·         Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

          Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.

          Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.

           

          ·         Expression of the potential therapeutic target CXXC5 in primary acute myeloid
          leukemia cells – high expression is associated with adverse prognosis as
          well as altered intracellular signaling and transcriptional regulation.

          Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.

          Oncotarget. 2014 Dec 26

           

          ·         Acquired resistance to endocrine treatments is associated to tumor-specific
          molecular changes in patient-derived luminal breast cancer xenografts.

          Cottu
          PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
          Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
          Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
          Roman-Roman S, Marangoni E.

          Clin Cancer Res. 2014 Aug 15;20(16):4314-25.

           

          ·         Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.

          Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.

          Cell Reports. 2014 May 10

           

          ·         Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

          Lopez-Mejia
          IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
          Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

          EMBO Rep., 2014 Mar 17

           

          ·         RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

          Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.

          Mol Cell. 2013 Dec

           

          ·         Sudemycin E influences alternative splicing and changes chromatin modifications.

          Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.

          Nucleic Acids Res. 2014 Mar 11.

           

          ·         A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

          Pesson
          M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
          Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.

          PLoS One. 2014 Feb 6.

           

          ·         A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
          application to the study of genes involved in the response to targeted
          anticancer therapies

          Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.

          Mol. Cancer, 2014 Jan.

           

          ·         Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.

          Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S

          PLoS One. 2013 Dec.

           

          ·         CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.

          Astori
          A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
          Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
          Lillehaug JR, Pendino F, Bruserud O

          Oncotarget, 2013 Aug.

           

          ·         BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
          of AML by targeting primitive LSK and progenitor cells.

          Beurlet
          S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
          Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
          Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
          West R, Fenaux P, Chomienne C, Padua RA.

          Blood. 2013 Aug

           

          ·         SF3B1 mutations are associated with alternative splicing in uveal melanoma.

          Furney
          SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
          S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
          R.

          Cancer Discov. 2013 Jul 16

           

          ·         Molecular characterization of a patient presumed to have prader-willi syndrome.

          Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.

          Clin Med Insights Case Rep. 2013 May 10.

           

          ·         Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.

          Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

          Cell Reprogram. 2013 May 10.

           

          ·         Genome
          wide array analysis indicates that an amyotrophic lateral sclerosis
          mutation of FUS causes an early increase of CAMK2N2 in vitro.

          Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.

          Biochim Biophys Acta. 2013 Mar

           

          ·         Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

          Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.

          Nucleic Acids Res. 2013 Feb 7.

           

          ·         hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

          Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.

          EMBO J. 2013 Feb 5. , DOI

           

          ·         Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

          Sonia
          Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
          Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
          Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
          Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
          Renato C. Monteiro, Pierre de la Grange, Richard Moreau

          J Hepatol. 2013 Jan 12. , DOI

           

          ·         The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.

          Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.

          EMBO Mol Med. 2013 Jan 9. , DOI

           

          ·         Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.

          Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.

          PLoS One. 2012;7(12):e51266. , DOI

           

          ·         TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.

          Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.

          Oncogene. 2012 Nov 5. , DOI

           

          ·         Argonaute proteins couple chromatin silencing to alternative splicing.

          Ameyar-Zazoua
          M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
          R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
          C, Batsché E, Harel-Bellan A.

          Nat Struct Mol Biol. 2012 Sep 9

           

          ·         Lipocalin
          2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
          downstream of NFAT1 to regulate breast cancer cell invasion.

          Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

          J Cell Sci. 2012 Jul 5.

           

          ·         A transcriptome signature of endothelial lymphatic cells coexists with
          the chronic oxidative stress signature in radiation-induced
          post-radiotherapy breast angiosarcomas.

          Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.

          Carcinogenesis. 2012 May 7.,

           

          ·         Sperm transcriptome profiling in oligozoospermia.

          Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.

          J Assist Reprod Genet. 2012 Jan;29(1):3-10

           

          ·         Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.

          Jia Y, Mu JC, Ackerman SL.

          Cell. 2012 Jan 20;148(1-2):296-308

           

          ·         Identification
          of novel androgen-regulated pathways and mRNA isoforms through
          genome-wide exon-specific profiling of the LNCaP transcriptome.

          Rajan
          P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
          K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
          Leung HY, Elliott DJ.

          PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14

           

          ·         Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

          Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

          Human Molecular Genetics 2011, Jun 30

           

          ·         Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

          Fugier
          C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
          V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
          P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
          Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
          D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
          Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

          Nat Med. 2011 May 29

           

          ·         Melanoma
          spheroids grown under neural crest cell conditions are highly plastic
          migratory/invasive tumor cells endowed with immunomodulator function.

          Ramgolam
          K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
          Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R

          PLoS One 2011;6(4):e18784

           

          ·         Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

          Saint-André V, Batsché E, Rachez C, Muchardt C.

          Nature Structural and Molecular Biology 2011, 18(3):337-44

           

          ·         Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

          Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

          Nat Struct Mol Biol. 2010 Aug 15

           

          ·         Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.

          Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.

          Cancer Research 2010 Apr 20.

           

          ·         Splicing factor and exon profiling across human tissues.

          de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.

          Nucleic Acids Research. 2010 Jan 27.

           

          ·         Exon-Based
          Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
          Exons Whose Expression Is Associated with Metastasis.

          Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.

          Cancer Research 2010 Jan 26.

           

          ·         Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

          El-Bchiri
          J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
          la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.

          PLoS ONE. 2008, 3(7):e2583.

           

          ·         Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

          Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.

          Mol Cell Biol. 2007, 27(20):7315-33.

           

          ·         A new advance in alternative splicing databases: from catalogue to
          detailed analysis of regulation of expression and function of human
          alternative splicing variants.

          de la Grange P, Dutertre M, Correa M, Auboeuf D.

          BMC Bioinformatics 2007, 8:180

           

          ·         ASEtrap: a biological method for speeding up the exploration of spliceomes.

          Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.

          Genome Res. 2006, 16(6):776-86.

           

          ·         FAST DB: a website resource for the study of the expression regulation of human gene products.

          de la Grange P, Dutertre M, Martin N, Auboeuf D.

          Nucleic Acids Research 2005, 33(13):4276-4284.

          PMI

          Eur J Hum Genet. 2022 Mar 11.

          Brain. 2022 Mar 17

           Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns

          Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin

          • Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
            Maxime
            Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
            Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
            Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
            Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
            Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
            Fenaux, Lionel Ades, Nicolas Dulphy

            Nat Commun. 2023 Feb 03 / 36737440

          MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming

           

          • BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
          Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua

          Int J Mol Sci. 2021 Sep 30 / PMID: 34638998

          • Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
          Daphné Krzisch, Nayara Guedes, Clémentine Boccon-Gibod, Marine Baron,
          Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
          Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
          Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
          Leukemia Organization) group
          Am J Hematol. 2021 Aug 31 / PMID: 34462944

          • Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
          Juliette Paillet, Céleste Plantureux, Sarah Lévesque, Julie Le Naour,
          Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
          Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
          Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
          Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
          Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
          Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
          Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
          Guido Kroemer, Jonathan G Pol
          J Exp Med. 2021 Oct 4 / PMID: 34495298

          • Genes coding for transcription factors involved in stem cell
            maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
            COPD bronchial epithelial progenitors.

          Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.

          Mol Biol Rep. 2021 Aug 26 / PMID: 34436724

          • Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.

          Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
          la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.

          Cereb Cortex. 2021 May 21 / PMID: 34023893

          • Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
          E El Khouri, J Ghoumid, D Haye, F Giuliano, L Drevillon, A
          Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
          Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
          Mol Psychiatry. 2021 Apr 19. / PMID: 33867523
          • Activation of Macrophages by Lysophosphatidic Acid through
            the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
            Sclerosis Pathogenesis.

          Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
          Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
          Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
          Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.

          Mol Neurobiol. 2021 Feb / PMID: 32974731

          ·         Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

          Emmanuel
          Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
          Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
          Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
          Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
          Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
          Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5

           

          ·         Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.

          Ben
          Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
          Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
          10.1007/s12015-021-10123-z.

           

          ·         Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
          with oligodendroglial hyperplasia in epilepsy (MOGHE)

          Thomas
          Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
          Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
          Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
          Blumcke, Stéphanie Baulac

          Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.

           

          ·         Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?

          Lerebours
          F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
          S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.

          J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.

           

          ·         Plasma microRNA signature in presymptomatic and symptomatic subjects with
          C9orf72-associated frontotemporal dementia and amyotrophic lateral
          sclerosis.

          Kmetzsch
          V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
          Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
          Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.

          J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.

           

          ·         Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

          Casulleras
          M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
          López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
          Moreau R, Arroyo V, Clària J.

          Sci Transl Med. 2020 Oct 21;12(566):eaax5135.

           

          ·         Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

          Chiot
          A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
          Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
          Boillée S.

          Nat Neurosci. 2020 Oct 19.

           

          ·         Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

          Bogdan
          Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
          Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos

          Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.

           

          ·         Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.

          Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.

          Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019

           

          ·         Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.

          Romagnoli
          M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
          Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
          MA, Glukhova MA, Faraldo MM.

          Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552

           

          ·         ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.

          Gacem
          N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
          Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.

          Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5

           

          ·         Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.

          Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.

          Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117

           

          ·         An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

          Traoré
          M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
          Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
          Falcone S

          Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131

           

          ·         A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

          Lévesque
          S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
          EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
          Kroemer G, Pol JG

          Oncoimmunology. 2019 Sep 7;8(11):e1657375

           

          ·         SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.

          Leman
          R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
          Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S

          Bioinformatics. 2019 Oct 16. pii: btz784

           

          ·         Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

          Furlanis E, Traunmüller L, Fucile G, Scheiffele P.

          Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5

           

          ·         Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

          Baldassari
          S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
          C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
          M, Baulac S

          Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

           

          ·         Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

          Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S

          Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861

           

          ·         Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

          Sica
          V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
          Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
          Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
          Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

          Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

           

          ·         Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

          Liu
          P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
          Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
          Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
          Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
          Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

          Nat Commun. 2019 Apr 2;10(1):1486

           

          ·         Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

          Romagnoli
          M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
          Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
          Raymond K, Glukhova MA, Faraldo MM.

          Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6

           

          ·         Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
          differentiation-dependent metabolic responses to IFNG stimulation.

          Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.

          Cell Death Dis. 2019 Mar 20;10(4):277

           

          ·         Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.

          Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.

          Cell Rep. 2019 Mar 12;26(11):2929-2941

           

          ·         p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.

          Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.

          Breast Cancer Res. 2019 Jan 25;21(1):13

           

          ·         Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

          Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

          Sci Rep. 2019 Jan 28;9(1):792

           

          ·         Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.

          Daruich
          A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
          JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.

          Sci Adv. 2019 Jan 9;5(1):eaau9940

           

          ·         Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

          Domenech
          C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
          Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.

          Stem Cell Reports 2018, Nov 13;11(5):1075-1091

           

          ·         The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

          Tury
          S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
          V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
          Lallemand F, Marangoni E, Bièche I, Callens C.

          J Pathol. 2018 Jun 7

           

          ·         Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.

          Bruno,
          A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
          L, Rahimian, A, Lemoine, F, de la Grange, P,   Guégan, J, Bielle, F,
          Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
          Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
          Mokhtari, K, Hoang-Xuan, K, Alentorn, A.

          Neuro Oncol. 2018 Jul 5;20(8):1092-1100

           

          ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

          Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

          Sci Rep. 2017 Dec 14;7(1):17595.

           

          ·         Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

          Cifdaloz
          M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
          Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
          E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
          Megías D, Valcárcel J, Soengas MS.

          Nat Commun. 2017 Dec 21;8(1):2249.

           

          ·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

          Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

          Sci Rep. 2017 Dec 14;7(1):17595

           

          ·         Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

          Glentis
          A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
          Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
          Plodinec M, Vignjevic DM.

          Nat Commun. 2017 Oct 13;8(1):924.

           

          ·         hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell

          Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.

          Nucleic Acids Res. 2017 Oct 3

          ·         Neurotrophic factors for motor neurons: an à la carte menu

          Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.

          Med Sci (Paris). 2017 Oct;33(10):835-839

           

          ·         Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.

          Grégoire
          Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
          Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
          Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
          Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
          Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
          Alexandra Martins, Dominique Vaur, Sophie Krieger.

          Eur J Hum Genet. 2017 Oct;25(10):1147-1154

           

          ·         Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
          and Sensitivity to the DNA Repair Inhibitor AsiDNA.

          Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.

          Cancer Res. 2017 Aug 15;77(16):4207-4216

           

          ·         Pre-therapy liver transcriptome landscape in Indian and French patients with severe
          alcoholic hepatitis and steroid responsiveness

          Shvetank
          Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
          Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
          Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
          Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
          Richard Moreau & Shiv K. Sarin.

          Scientific Reports 2017 Jul 28;7(1):6816

           

          ·         Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

          Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.

          Nucleic Acids Res. 2017 Jun 7

           

          ·         Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

          Boulay
          AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
          Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
          Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.

          Cell Discov. 2017 Mar 28

           

          ·         An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation

          Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.

          Developmental Cell 2017 Mar 24

           

          ·         Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

          Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

          Proc Natl Acad Sci U S A. 2017 Mar 7

           

          ·         Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

          Santo
          J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
          S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
          G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,

          Int J Obes (Lond). 2017

           

          ·         Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

          Weiss
          E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
          Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
          Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
          Lotersztajn S, Moreau R.,

          J Hepatol. 2016 Dec 28

           

          ·         Deregulation of pre-messenger RNA splicing and rare diseases.

          de la Grange P.

          Med Sci (Paris). 2016 Dec

           

          ·         Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.

          Mauger O, Lemoine F, Scheiffele P.,

          Neuron. 2016 Nov 21

           

          ·         Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
          progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.

          La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C

          Elife. 2016 Nov 15

           

          ·         Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
          Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
          Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
          Neuronal Cultures.

          Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C

          Mol Neurobiol. 2016 Nov 14

           

          ·         Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

          Møller
          RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
          Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
          S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
          G, Cooper GM, Baulac S.

          Neurol Genet. 2016 Oct 31

           

          ·         p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

          Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.

          Oncogene. 2016 Oct 24

           

          ·         Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.

          Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

          Stem Cells Dev. 2016 Oct 17

           

          ·         Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

          Klein
          P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
          L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
          Butler-Browne G, Bastide B, Mouly V, Trollet C.

          Nucleic Acids Res. 2016 Aug 9

           

          ·         Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

          Vallerand
          D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
          Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
          Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
          Savina A, Decaudin D.

          PLoS One. 2016 Jul 7

           

          ·         Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.

          Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.

          Mol Neurodegener. 2016 Jun

           

          ·         Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

          Weckhuysen
          S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
          Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
          Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.

          Epilepsia 2016 May 13.

           

          ·         Control of neuronal synapse specification by a highly dedicated alternative splicing program

          Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.

          Science. 2016 May 12

           

          ·         GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.

          Guerenne
          L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
          Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
          Pla M, Fenaux P, Padua RA, Chomienne C, Krief P

          Hematol Oncol. 2016 Jan 27

           

          ·         Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
          Associated with the Upregulation of Wingless-Related Integration and
          Bone Morphogenetic Protein Signaling in Dark Agouti Rats.

          Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.

          Med Princ Pract. 2016

           

          ·         Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

          Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,

          Stem Cell Reports. 2015 Nov 11

           

          ·         From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

          Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,

          Biochim Biophys Acta. 2015 Oct 26.

           

          ·         Developmental clock compromises human twin model created by embryo splitting

          Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,

          Hum Reprod. 2015 Oct 21

           

          ·         MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
          and can be explored for human embryo reproductive competence assessment

          Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.

          Fertil Steril. 2015 Oct 9

           

          ·         Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
          provide insights into tumor biology and therapeutic leads.

          Auguste
          A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
          E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
          Galmiche L, Kalfa N, Veitia RA

          Hum Mol Genet. 2015 Sep 11.

           

          ·         TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

          De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.

          NAR. 2015 Aug

           

          ·         SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.

          Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.

          Gene, 2015 Jul.

           

          ·         DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

          Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.

          Blood. 2015 Apr 16

           

          ·         Disruption of SF3B1 results in deregulated expression and splicing of key genes
          and pathways in myelodysplastic syndrome hematopoietic stem and
          progenitor cells

          H
          Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
          Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
          Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
          Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
          1092–1103

           

          ·         Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

          Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.

          Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.

           

          ·         Expression of the potential therapeutic target CXXC5 in primary acute myeloid
          leukemia cells – high expression is associated with adverse prognosis as
          well as altered intracellular signaling and transcriptional regulation.

          Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.

          Oncotarget. 2014 Dec 26

           

          ·         Acquired resistance to endocrine treatments is associated to tumor-specific
          molecular changes in patient-derived luminal breast cancer xenografts.

          Cottu
          PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
          Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
          Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
          Roman-Roman S, Marangoni E.

          Clin Cancer Res. 2014 Aug 15;20(16):4314-25.

           

          ·         Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.

          Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.

          Cell Reports. 2014 May 10

           

          ·         Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

          Lopez-Mejia
          IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
          Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

          EMBO Rep., 2014 Mar 17

           

          ·         RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

          Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.

          Mol Cell. 2013 Dec

           

          ·         Sudemycin E influences alternative splicing and changes chromatin modifications.

          Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.

          Nucleic Acids Res. 2014 Mar 11.

           

          ·         A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

          Pesson
          M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
          Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.

          PLoS One. 2014 Feb 6.

           

          ·         A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
          application to the study of genes involved in the response to targeted
          anticancer therapies

          Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.

          Mol. Cancer, 2014 Jan.

           

          ·         Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.

          Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S

          PLoS One. 2013 Dec.

           

          ·         CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.

          Astori
          A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
          Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
          Lillehaug JR, Pendino F, Bruserud O

          Oncotarget, 2013 Aug.

           

          ·         BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
          of AML by targeting primitive LSK and progenitor cells.

          Beurlet
          S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
          Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
          Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
          West R, Fenaux P, Chomienne C, Padua RA.

          Blood. 2013 Aug

           

          ·         SF3B1 mutations are associated with alternative splicing in uveal melanoma.

          Furney
          SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
          S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
          R.

          Cancer Discov. 2013 Jul 16

           

          ·         Molecular characterization of a patient presumed to have prader-willi syndrome.

          Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.

          Clin Med Insights Case Rep. 2013 May 10.

           

          ·         Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.

          Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

          Cell Reprogram. 2013 May 10.

           

          ·         Genome
          wide array analysis indicates that an amyotrophic lateral sclerosis
          mutation of FUS causes an early increase of CAMK2N2 in vitro.

          Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.

          Biochim Biophys Acta. 2013 Mar

           

          ·         Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

          Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.

          Nucleic Acids Res. 2013 Feb 7.

           

          ·         hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

          Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.

          EMBO J. 2013 Feb 5. , DOI

           

          ·         Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

          Sonia
          Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
          Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
          Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
          Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
          Renato C. Monteiro, Pierre de la Grange, Richard Moreau

          J Hepatol. 2013 Jan 12. , DOI

           

          ·         The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.

          Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.

          EMBO Mol Med. 2013 Jan 9. , DOI

           

          ·         Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.

          Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.

          PLoS One. 2012;7(12):e51266. , DOI

           

          ·         TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.

          Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.

          Oncogene. 2012 Nov 5. , DOI

           

          ·         Argonaute proteins couple chromatin silencing to alternative splicing.

          Ameyar-Zazoua
          M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
          R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
          C, Batsché E, Harel-Bellan A.

          Nat Struct Mol Biol. 2012 Sep 9

           

          ·         Lipocalin
          2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
          downstream of NFAT1 to regulate breast cancer cell invasion.

          Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

          J Cell Sci. 2012 Jul 5.

           

          ·         A transcriptome signature of endothelial lymphatic cells coexists with
          the chronic oxidative stress signature in radiation-induced
          post-radiotherapy breast angiosarcomas.

          Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.

          Carcinogenesis. 2012 May 7.,

           

          ·         Sperm transcriptome profiling in oligozoospermia.

          Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.

          J Assist Reprod Genet. 2012 Jan;29(1):3-10

           

          ·         Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.

          Jia Y, Mu JC, Ackerman SL.

          Cell. 2012 Jan 20;148(1-2):296-308

           

          ·         Identification
          of novel androgen-regulated pathways and mRNA isoforms through
          genome-wide exon-specific profiling of the LNCaP transcriptome.

          Rajan
          P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
          K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
          Leung HY, Elliott DJ.

          PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14

           

          ·         Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

          Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

          Human Molecular Genetics 2011, Jun 30

           

          ·         Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

          Fugier
          C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
          V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
          P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
          Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
          D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
          Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

          Nat Med. 2011 May 29

           

          ·         Melanoma
          spheroids grown under neural crest cell conditions are highly plastic
          migratory/invasive tumor cells endowed with immunomodulator function.

          Ramgolam
          K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
          Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R

          PLoS One 2011;6(4):e18784

           

          ·         Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

          Saint-André V, Batsché E, Rachez C, Muchardt C.

          Nature Structural and Molecular Biology 2011, 18(3):337-44

           

          ·         Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

          Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

          Nat Struct Mol Biol. 2010 Aug 15

           

          ·         Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.

          Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.

          Cancer Research 2010 Apr 20.

           

          ·         Splicing factor and exon profiling across human tissues.

          de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.

          Nucleic Acids Research. 2010 Jan 27.

           

          ·         Exon-Based
          Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
          Exons Whose Expression Is Associated with Metastasis.

          Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.

          Cancer Research 2010 Jan 26.

           

          ·         Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

          El-Bchiri
          J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
          la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.

          PLoS ONE. 2008, 3(7):e2583.

           

          ·         Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

          Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.

          Mol Cell Biol. 2007, 27(20):7315-33.

           

          ·         A new advance in alternative splicing databases: from catalogue to
          detailed analysis of regulation of expression and function of human
          alternative splicing variants.

          de la Grange P, Dutertre M, Correa M, Auboeuf D.

          BMC Bioinformatics 2007, 8:180

           

          ·         ASEtrap: a biological method for speeding up the exploration of spliceomes.

          Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.

          Genome Res. 2006, 16(6):776-86.

           

          ·         FAST DB: a website resource for the study of the expression regulation of human gene products.

          de la Grange P, Dutertre M, Martin N, Auboeuf D.

          Nucleic Acids Research 2005, 33(13):4276-4284.

          PMI