• Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.

Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren, Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz. Mol Neurobiol. 2021 Feb

·         Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.

Emmanuel Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti, Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan, Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5

 

·         Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.

Ben Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi: 10.1007/s12015-021-10123-z.

 

·         Frequent SLC35A2 brain mosaicism in mild malformation of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE)

Thomas Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim, Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar Blumcke, Stéphanie Baulac

Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.

 

·         Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?

Lerebours F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.

J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.

 

·         Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.

Kmetzsch V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L, Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P, Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.

J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.

 

·         Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

Casulleras M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E, López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P, Moreau R, Arroyo V, Clària J.

Sci Transl Med. 2020 Oct 21;12(566):eaax5135.

 

·         Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

Chiot A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS, Boillée S.

Nat Neurosci. 2020 Oct 19.

 

·         Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.

Bogdan Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos

Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.

 

·         Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.

Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.

Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019

 

·         Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.

Romagnoli M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier MA, Glukhova MA, Faraldo MM.

Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552

 

·         ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.

Gacem N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J, Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.

Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5

 

·         Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.

Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.

Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117

 

·         An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.

Traoré M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B, Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F, Falcone S

Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131

 

·         A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

Lévesque S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L, Kroemer G, Pol JG

Oncoimmunology. 2019 Sep 7;8(11):e1657375

 

·         SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.

Leman R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L, Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S

Bioinformatics. 2019 Oct 16. pii: btz784

 

·         Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs

Furlanis E, Traunmüller L, Fucile G, Scheiffele P.

Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5

 

·         Dissecting the genetic basis of focal cortical dysplasia: a large cohort study

Baldassari S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux M, Baulac S

Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5

 

·         Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression

Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S

Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861

 

·         Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.

Sica V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S, Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N, Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC, Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.

Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.

 

·         Crizotinib-induced immunogenic cell death in non-small cell lung cancer.

Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.

Nat Commun. 2019 Apr 2;10(1):1486

 

·         Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.

Romagnoli M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA, Raymond K, Glukhova MA, Faraldo MM.

Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6

 

·         Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals differentiation-dependent metabolic responses to IFNG stimulation.

Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.

Cell Death Dis. 2019 Mar 20;10(4):277

 

·         Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.

Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.

Cell Rep. 2019 Mar 12;26(11):2929-2941

 

·         p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.

Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.

Breast Cancer Res. 2019 Jan 25;21(1):13

 

·         Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.

Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.

Sci Rep. 2019 Jan 28;9(1):792

 

·         Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.

Daruich A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.

Sci Adv. 2019 Jan 9;5(1):eaau9940

 

·         Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.

Domenech C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P, Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.

Stem Cell Reports 2018, Nov 13;11(5):1075-1091

 

·         The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.

Tury S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A, Lallemand F, Marangoni E, Bièche I, Callens C.

J Pathol. 2018 Jun 7

 

·         Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.

Bruno, A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron, L, Rahimian, A, Lemoine, F, de la Grange, P,   Guégan, J, Bielle, F, Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C, Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C, Mokhtari, K, Hoang-Xuan, K, Alentorn, A.

Neuro Oncol. 2018 Jul 5;20(8):1092-1100

 

·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

Sci Rep. 2017 Dec 14;7(1):17595.

 

·         Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.

Cifdaloz M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J, Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL, Megías D, Valcárcel J, Soengas MS.

Nat Commun. 2017 Dec 21;8(1):2249.

 

·         Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.

Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.

Sci Rep. 2017 Dec 14;7(1):17595

 

·         Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane

Glentis A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F, Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG, Plodinec M, Vignjevic DM.

Nat Commun. 2017 Oct 13;8(1):924.

 

·         hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell

Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.

Nucleic Acids Res. 2017 Oct 3

 

·         Neurotrophic factors for motor neurons: an à la carte menu

Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.

Med Sci (Paris). 2017 Oct;33(10):835-839

 

·         Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.

Grégoire Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg, Alexandra Martins, Dominique Vaur, Sophie Krieger.

Eur J Hum Genet. 2017 Oct;25(10):1147-1154

 

·         Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability and Sensitivity to the DNA Repair Inhibitor AsiDNA.

Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.

Cancer Res. 2017 Aug 15;77(16):4207-4216

 

·         Pre-therapy liver transcriptome landscape in Indian and French patients with severe alcoholic hepatitis and steroid responsiveness

Shvetank Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K. Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot, Richard Moreau & Shiv K. Sarin.

Scientific Reports 2017 Jul 28;7(1):6816

 

·         Alternative splicing of CNOT7 diversifies CCR4-NOT functions.

Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.

Nucleic Acids Res. 2017 Jun 7

 

·         Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.

Boulay AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M, Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S, Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.

Cell Discov. 2017 Mar 28

 

·         An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation

Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.

Developmental Cell 2017 Mar 24

 

·         Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.

Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.

Proc Natl Acad Sci U S A. 2017 Mar 7

 

·         Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.

Santo J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,

Int J Obes (Lond). 2017

 

·         Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.

Weiss E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C, Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D, Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C, Lotersztajn S, Moreau R.,

J Hepatol. 2016 Dec 28

 

·         Deregulation of pre-messenger RNA splicing and rare diseases.

de la Grange P.

Med Sci (Paris). 2016 Dec

 

·         Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.

Mauger O, Lemoine F, Scheiffele P.,

Neuron. 2016 Nov 21

 

·         Sam68 promotes self-renewal and glycolytic metabolism in mouse neural progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.

La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C

Elife. 2016 Nov 15

 

·         Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes Associated with Cellular Morphology and Cytoskeleton Dynamics and Is Required for Neurite Outgrowth in Neuroblastoma Cells and Primary Neuronal Cultures.

Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C

Mol Neurobiol. 2016 Nov 14

 

·         Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.

Møller RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM, Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli G, Cooper GM, Baulac S.

Neurol Genet. 2016 Oct 31

 

·         p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.

Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.

Oncogene. 2016 Oct 24

 

·         Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.

Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D

Stem Cells Dev. 2016 Oct 17

 

·         Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.

Klein P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G, Butler-Browne G, Bastide B, Mouly V, Trollet C.

Nucleic Acids Res. 2016 Aug 9

 

·         Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.

Vallerand D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P, Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S, Savina A, Decaudin D.

PLoS One. 2016 Jul 7

 

·         Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.

Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.

Mol Neurodegener. 2016 Jun

 

·         Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.

Weckhuysen S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I, Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B, Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.

Epilepsia 2016 May 13.

 

·         Control of neuronal synapse specification by a highly dedicated alternative splicing program

Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.

Science. 2016 May 12

 

·         GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.

Guerenne L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P, Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME, Pla M, Fenaux P, Padua RA, Chomienne C, Krief P

Hematol Oncol. 2016 Jan 27

 

·         Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are Associated with the Upregulation of Wingless-Related Integration and Bone Morphogenetic Protein Signaling in Dark Agouti Rats.

Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.

Med Princ Pract. 2016

 

·         Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study

Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,

Stem Cell Reports. 2015 Nov 11

 

·         From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.

Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,

Biochim Biophys Acta. 2015 Oct 26.

 

·         Developmental clock compromises human twin model created by embryo splitting

Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,

Hum Reprod. 2015 Oct 21

 

·         MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells and can be explored for human embryo reproductive competence assessment

Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.

Fertil Steril. 2015 Oct 9

 

·         Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations provide insights into tumor biology and therapeutic leads.

Auguste A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A, Galmiche L, Kalfa N, Veitia RA

Hum Mol Genet. 2015 Sep 11.

 

·         TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways

De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.

NAR. 2015 Aug

 

·         SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.

Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.

Gene, 2015 Jul.

 

·         DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.

Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.

Blood. 2015 Apr 16

 

·         Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells

H Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29, 1092–1103

 

·         Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.

Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.

Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.

 

·         Expression of the potential therapeutic target CXXC5 in primary acute myeloid leukemia cells – high expression is associated with adverse prognosis as well as altered intracellular signaling and transcriptional regulation.

Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.

Oncotarget. 2014 Dec 26

 

·         Acquired resistance to endocrine treatments is associated to tumor-specific molecular changes in patient-derived luminal breast cancer xenografts.

Cottu PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A, Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V, Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY, Roman-Roman S, Marangoni E.

Clin Cancer Res. 2014 Aug 15;20(16):4314-25.

 

·         Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.

Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.

Cell Reports. 2014 May 10

 

·         Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.

Lopez-Mejia IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C, Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.

EMBO Rep., 2014 Mar 17

 

·         RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.

Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.

Mol Cell. 2013 Dec

 

·         Sudemycin E influences alternative splicing and changes chromatin modifications.

Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.

Nucleic Acids Res. 2014 Mar 11.

 

·         A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer

Pesson M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M, Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.

PLoS One. 2014 Feb 6.

 

·         A dedicated microarray for in-depth analysis of pre-mRNA splicing events: application to the study of genes involved in the response to targeted anticancer therapies

Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.

Mol. Cancer, 2014 Jan.

 

·         Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.

Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S

PLoS One. 2013 Dec.

 

·         CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.

Astori A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P, Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S, Lillehaug JR, Pendino F, Bruserud O

Oncotarget, 2013 Aug.

 

·         BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model of AML by targeting primitive LSK and progenitor cells.

Beurlet S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L, Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M, West R, Fenaux P, Chomienne C, Padua RA.

Blood. 2013 Aug

 

·         SF3B1 mutations are associated with alternative splicing in uveal melanoma.

Furney SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais R.

Cancer Discov. 2013 Jul 16

 

·         Molecular characterization of a patient presumed to have prader-willi syndrome.

Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.

Clin Med Insights Case Rep. 2013 May 10.

 

·         Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.

Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.

Cell Reprogram. 2013 May 10.

 

·         Genome wide array analysis indicates that an amyotrophic lateral sclerosis mutation of FUS causes an early increase of CAMK2N2 in vitro.

Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.

Biochim Biophys Acta. 2013 Mar

 

·         Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.

Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.

Nucleic Acids Res. 2013 Feb 7.

 

·         hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.

Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.

EMBO J. 2013 Feb 5. , DOI

 

·         Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.

Sonia Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu, Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier, Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer, Renato C. Monteiro, Pierre de la Grange, Richard Moreau

J Hepatol. 2013 Jan 12. , DOI

 

·         The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.

Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.

EMBO Mol Med. 2013 Jan 9. , DOI

 

·         Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.

Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.

PLoS One. 2012;7(12):e51266. , DOI

 

·         TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.

Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.

Oncogene. 2012 Nov 5. , DOI

 

·         Argonaute proteins couple chromatin silencing to alternative splicing.

Ameyar-Zazoua M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt C, Batsché E, Harel-Bellan A.

Nat Struct Mol Biol. 2012 Sep 9

 

·         Lipocalin 2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act downstream of NFAT1 to regulate breast cancer cell invasion.

Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.

J Cell Sci. 2012 Jul 5.

 

·         A transcriptome signature of endothelial lymphatic cells coexists with the chronic oxidative stress signature in radiation-induced post-radiotherapy breast angiosarcomas.

Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.

Carcinogenesis. 2012 May 7.,

 

·         Sperm transcriptome profiling in oligozoospermia.

Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.

J Assist Reprod Genet. 2012 Jan;29(1):3-10

 

·         Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.

Jia Y, Mu JC, Ackerman SL.

Cell. 2012 Jan 20;148(1-2):296-308

 

·         Identification of novel androgen-regulated pathways and mRNA isoforms through genome-wide exon-specific profiling of the LNCaP transcriptome.

Rajan P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN, Leung HY, Elliott DJ.

PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14

 

·         Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.

Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.

Human Molecular Genetics 2011, Jun 30

 

·         Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.

Fugier C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I, Bassez G, Laporte J, Furling D, Charlet-Berguerand N.

Nat Med. 2011 May 29

 

·         Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function.

Ramgolam K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM, Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R

PLoS One 2011;6(4):e18784

 

·         Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.

Saint-André V, Batsché E, Rachez C, Muchardt C.

Nature Structural and Molecular Biology 2011, 18(3):337-44

 

·         Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.

Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.

Nat Struct Mol Biol. 2010 Aug 15

 

·         Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.

Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.

Cancer Research 2010 Apr 20.

 

·         Splicing factor and exon profiling across human tissues.

de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.

Nucleic Acids Research. 2010 Jan 27.

 

·         Exon-Based Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative Exons Whose Expression Is Associated with Metastasis.

Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.

Cancer Research 2010 Jan 26.

 

·         Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.

El-Bchiri J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.

PLoS ONE. 2008, 3(7):e2583.

 

·         Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.

Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.

Mol Cell Biol. 2007, 27(20):7315-33.

 

·         A new advance in alternative splicing databases: from catalogue to detailed analysis of regulation of expression and function of human alternative splicing variants.

de la Grange P, Dutertre M, Correa M, Auboeuf D.

BMC Bioinformatics 2007, 8:180

 

·         ASEtrap: a biological method for speeding up the exploration of spliceomes.

Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.

Genome Res. 2006, 16(6):776-86.

 

·         FAST DB: a website resource for the study of the expression regulation of human gene products.

de la Grange P, Dutertre M, Martin N, Auboeuf D.

Nucleic Acids Research 2005, 33(13):4276-4284.