- Antibody Mediated Rejection and T-cell Mediated Rejection Molecular Signatures Using Next-Generation Sequencing in Kidney Transplant Biopsies
Cortes Garcia E, Giarraputo A, Racapé M, Goutaudier V, Ursule-Dufait C, de la Grange P, Adoux L, Raynaud M, Couderau C, Mezine F, Dagobert J, Bestard O, Moreso F, Villard J, Halleck F, Giral M, Brouard S, Danger R, Gourraud PA, Rabant M, Couzi L, Le Quintrec M, Kamar N, Morelon E, Vrtovsnik F, Taupin JL, Snanoudj R, Legendre C, Anglicheau D, Budde K, Lefaucheur C, Loupy A, Aubert O.
Transpl Int. 2024 Jul 10 / 39050190
- Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer
Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina
Immunology. 2024 Jul 2 / 38953295
- Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer
Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette
J Exp Clin Cancer Res. 2024 Feb 27 / 38413979
- Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development
Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette
Nucleic Acids Res. 2024 Feb 7 / 38324473
- A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner
Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele
Cell Rep. Mar 28 / 36862556
- BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance
Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Cancer Discov. 2023 Nov 1 / 37623817
- Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression
Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue
J Invest Dermatol. 2023 Sep 20 / 37739336
- Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall
Cell Rep. 2023 Sep 13 / 37708024
- Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz
JHEP Rep. 2023 May 16 / 37520673
- Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs
Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm
Front Mol Neurosci. 2023 May 5 / 37266374
- Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity
Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl
Cell Mol Life Sci. 2023 May 15 / 37184603
- Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology
Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel
Exp Dermatol. 2023 May 6 / 37148203
- CDK12/13 promote splicing of proximal introns by enhancing the
interaction between RNA polymerase II and the splicing factor SF3B1Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn
Nat Commun. 2023 Apr 1 / 37005415
- T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros
Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
- RELA tunes innate-like interferon I/III responses in human T cells
Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas ManelJ Exp Med. 2023 Feb 23 / 36820829
- Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc DupuisNat Commun. 2023 May 1/ 36670122
- Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca AmatiInt J Mol Sci. 2023 Jan 6 / 36674633
- Cortical wiring by synapse type-specific control of local protein synthesis
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar MarínScience. 2022 Nov 25 / 36423280
- The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-KourbaliBr J Cancer. 2022 Dec 22 / 36550208
- RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan StammNucleic Acids Res. 2022 Dec 19 / 36533443
- Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.
Olivier Ariste, Pierre de la Grange, Reiner A Veitia
Clin Genet. 2022 Nov 10 / PMID: 36353970
- Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger
EMBO J. 2022 Sep 23 / PMID: 36149731
- A conserved molecular template underlies color pattern diversity in estrildid finches.
Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau
Sci Adv. 2022 Sep 2 / PMID: 36044564
- RNF213-associated urticarial lesions with hypercytokinemia
Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
Irina GiurgeaJ Allergy Clin Immunol. 2022 Jun 30 / PMID: 35780935
- Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine
Aging. 2022 May 4 / PMID: 35507806
- Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm
Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2022 Mar 24 / PMID: 34905599
- Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway
Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin
Brain. 2022 Mar 17 / PMID: 35298632
- Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data
Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet
Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653
- CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1
Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu
Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489
- Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia
Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin
Brain. 2022 Jan 4 / PMID: 34983064
- The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
- Epithelial colonization by gut dendritic cells promotes their functional diversification
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil
Immunity. December 14, 2021
https://www.sciencedirect.com/science/article/pii/S1074761321004994
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2021 Dec 14 / PMID: 34905599
- BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua
Int J Mol Sci. 2021 Sep 30 / PMID: 34638998
- Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
Leukemia Organization) group
- Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
Guido Kroemer, Jonathan G Pol
- Genes coding for transcription factors involved in stem cell
maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
COPD bronchial epithelial progenitors.
Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.
Mol Biol Rep. 2021 Aug 26 / PMID: 34436724
- Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.
Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.
Cereb Cortex. 2021 May 21 / PMID: 34023893
- Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
- Activation of Macrophages by Lysophosphatidic Acid through
the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
Sclerosis Pathogenesis.
Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.
Mol Neurobiol. 2021 Feb / PMID: 32974731
· Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.
Emmanuel
Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5
· Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.
Ben
Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
10.1007/s12015-021-10123-z.
· Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
with oligodendroglial hyperplasia in epilepsy (MOGHE)
Thomas
Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
Blumcke, Stéphanie Baulac
Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.
· Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?
Lerebours
F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.
J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.
· Plasma microRNA signature in presymptomatic and symptomatic subjects with
C9orf72-associated frontotemporal dementia and amyotrophic lateral
sclerosis.
Kmetzsch
V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.
J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.
· Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.
Casulleras
M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
Moreau R, Arroyo V, Clària J.
Sci Transl Med. 2020 Oct 21;12(566):eaax5135.
· Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Chiot
A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
Boillée S.
Nat Neurosci. 2020 Oct 19.
· Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.
Bogdan
Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos
Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.
· Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli
Cell Rep. 2020 Apr 14 / PMID: 32294449
· Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.
Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.
Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019
· Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.
Romagnoli
M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
MA, Glukhova MA, Faraldo MM.
Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552
· ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Gacem
N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.
Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5
· Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.
Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117
· An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Traoré
M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
Falcone S
Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131
· A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Lévesque
S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
Kroemer G, Pol JG
Oncoimmunology. 2019 Sep 7;8(11):e1657375
· SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.
Leman
R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S
Bioinformatics. 2019 Oct 16. pii: btz784
· Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Furlanis E, Traunmüller L, Fucile G, Scheiffele P.
Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5
· Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
Baldassari
S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
M, Baulac S
Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5
· Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression
Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S
Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861
· Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica
V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.
Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.
· Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
Liu
P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.
Nat Commun. 2019 Apr 2;10(1):1486
· Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.
Romagnoli
M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
Raymond K, Glukhova MA, Faraldo MM.
Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6
· Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
differentiation-dependent metabolic responses to IFNG stimulation.
Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.
Cell Death Dis. 2019 Mar 20;10(4):277
· Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.
Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.
Cell Rep. 2019 Mar 12;26(11):2929-2941
· p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.
Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.
Breast Cancer Res. 2019 Jan 25;21(1):13
· Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.
Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.
Sci Rep. 2019 Jan 28;9(1):792
· Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.
Daruich
A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.
Sci Adv. 2019 Jan 9;5(1):eaau9940
· Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.
Domenech
C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.
Stem Cell Reports 2018, Nov 13;11(5):1075-1091
· The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.
Tury
S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
Lallemand F, Marangoni E, Bièche I, Callens C.
J Pathol. 2018 Jun 7
· Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.
Bruno,
A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
L, Rahimian, A, Lemoine, F, de la Grange, P, Guégan, J, Bielle, F,
Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
Mokhtari, K, Hoang-Xuan, K, Alentorn, A.
Neuro Oncol. 2018 Jul 5;20(8):1092-1100
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595.
· Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
Cifdaloz
M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
Megías D, Valcárcel J, Soengas MS.
Nat Commun. 2017 Dec 21;8(1):2249.
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595
· Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Glentis
A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
Plodinec M, Vignjevic DM.
Nat Commun. 2017 Oct 13;8(1):924.
· hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell
Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.
Nucleic Acids Res. 2017 Oct 3
· Neurotrophic factors for motor neurons: an à la carte menu
Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.
Med Sci (Paris). 2017 Oct;33(10):835-839
· Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.
Grégoire
Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
Alexandra Martins, Dominique Vaur, Sophie Krieger.
Eur J Hum Genet. 2017 Oct;25(10):1147-1154
· Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
and Sensitivity to the DNA Repair Inhibitor AsiDNA.
Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.
Cancer Res. 2017 Aug 15;77(16):4207-4216
· Pre-therapy liver transcriptome landscape in Indian and French patients with severe
alcoholic hepatitis and steroid responsiveness
Shvetank
Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
Richard Moreau & Shiv K. Sarin.
Scientific Reports 2017 Jul 28;7(1):6816
· Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.
Nucleic Acids Res. 2017 Jun 7
· Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.
Boulay
AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.
Cell Discov. 2017 Mar 28
· An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation
Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.
Developmental Cell 2017 Mar 24
· Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.
Proc Natl Acad Sci U S A. 2017 Mar 7
· Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo
J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,
Int J Obes (Lond). 2017
· Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.
Weiss
E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
Lotersztajn S, Moreau R.,
J Hepatol. 2016 Dec 28
· Deregulation of pre-messenger RNA splicing and rare diseases.
de la Grange P.
Med Sci (Paris). 2016 Dec
· Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Mauger O, Lemoine F, Scheiffele P.,
Neuron. 2016 Nov 21
· Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.
La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C
Elife. 2016 Nov 15
· Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
Neuronal Cultures.
Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C
Mol Neurobiol. 2016 Nov 14
· Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.
Møller
RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
G, Cooper GM, Baulac S.
Neurol Genet. 2016 Oct 31
· p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.
Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.
Oncogene. 2016 Oct 24
· Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D
Stem Cells Dev. 2016 Oct 17
· Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.
Klein
P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
Butler-Browne G, Bastide B, Mouly V, Trollet C.
Nucleic Acids Res. 2016 Aug 9
· Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.
Vallerand
D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
Savina A, Decaudin D.
PLoS One. 2016 Jul 7
· Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.
Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.
Mol Neurodegener. 2016 Jun
· Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
Weckhuysen
S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.
Epilepsia 2016 May 13.
· Control of neuronal synapse specification by a highly dedicated alternative splicing program
Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.
Science. 2016 May 12
· GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne
L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
Pla M, Fenaux P, Padua RA, Chomienne C, Krief P
Hematol Oncol. 2016 Jan 27
· Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
Associated with the Upregulation of Wingless-Related Integration and
Bone Morphogenetic Protein Signaling in Dark Agouti Rats.
Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.
Med Princ Pract. 2016
· Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study
Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,
Stem Cell Reports. 2015 Nov 11
· From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,
Biochim Biophys Acta. 2015 Oct 26.
· Developmental clock compromises human twin model created by embryo splitting
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,
Hum Reprod. 2015 Oct 21
· MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
and can be explored for human embryo reproductive competence assessment
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.
Fertil Steril. 2015 Oct 9
· Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
provide insights into tumor biology and therapeutic leads.
Auguste
A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
Galmiche L, Kalfa N, Veitia RA
Hum Mol Genet. 2015 Sep 11.
· TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.
NAR. 2015 Aug
· SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.
Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.
Gene, 2015 Jul.
· DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.
Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.
Blood. 2015 Apr 16
· Disruption of SF3B1 results in deregulated expression and splicing of key genes
and pathways in myelodysplastic syndrome hematopoietic stem and
progenitor cells
H
Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
1092–1103
· Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.
Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.
Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.
· Expression of the potential therapeutic target CXXC5 in primary acute myeloid
leukemia cells – high expression is associated with adverse prognosis as
well as altered intracellular signaling and transcriptional regulation.
Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.
Oncotarget. 2014 Dec 26
· Acquired resistance to endocrine treatments is associated to tumor-specific
molecular changes in patient-derived luminal breast cancer xenografts.
Cottu
PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
Roman-Roman S, Marangoni E.
Clin Cancer Res. 2014 Aug 15;20(16):4314-25.
· Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.
Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.
Cell Reports. 2014 May 10
· Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia
IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.
EMBO Rep., 2014 Mar 17
· RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.
Mol Cell. 2013 Dec
· Sudemycin E influences alternative splicing and changes chromatin modifications.
Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.
Nucleic Acids Res. 2014 Mar 11.
· A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer
Pesson
M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.
PLoS One. 2014 Feb 6.
· A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
application to the study of genes involved in the response to targeted
anticancer therapies
Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.
Mol. Cancer, 2014 Jan.
· Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S
PLoS One. 2013 Dec.
· CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.
Astori
A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
Lillehaug JR, Pendino F, Bruserud O
Oncotarget, 2013 Aug.
· BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
of AML by targeting primitive LSK and progenitor cells.
Beurlet
S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
West R, Fenaux P, Chomienne C, Padua RA.
Blood. 2013 Aug
· SF3B1 mutations are associated with alternative splicing in uveal melanoma.
Furney
SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
R.
Cancer Discov. 2013 Jul 16
· Molecular characterization of a patient presumed to have prader-willi syndrome.
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.
Clin Med Insights Case Rep. 2013 May 10.
· Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.
Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.
Cell Reprogram. 2013 May 10.
· Genome
wide array analysis indicates that an amyotrophic lateral sclerosis
mutation of FUS causes an early increase of CAMK2N2 in vitro.
Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.
Biochim Biophys Acta. 2013 Mar
· Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.
Nucleic Acids Res. 2013 Feb 7.
· hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.
Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.
EMBO J. 2013 Feb 5. , DOI
· Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.
Sonia
Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
Renato C. Monteiro, Pierre de la Grange, Richard Moreau
J Hepatol. 2013 Jan 12. , DOI
· The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.
Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.
EMBO Mol Med. 2013 Jan 9. , DOI
· Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.
Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.
PLoS One. 2012;7(12):e51266. , DOI
· TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.
Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.
Oncogene. 2012 Nov 5. , DOI
· Argonaute proteins couple chromatin silencing to alternative splicing.
Ameyar-Zazoua
M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
C, Batsché E, Harel-Bellan A.
Nat Struct Mol Biol. 2012 Sep 9
· Lipocalin
2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
downstream of NFAT1 to regulate breast cancer cell invasion.
Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.
J Cell Sci. 2012 Jul 5.
· A transcriptome signature of endothelial lymphatic cells coexists with
the chronic oxidative stress signature in radiation-induced
post-radiotherapy breast angiosarcomas.
Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.
Carcinogenesis. 2012 May 7.,
· Sperm transcriptome profiling in oligozoospermia.
Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.
J Assist Reprod Genet. 2012 Jan;29(1):3-10
· Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.
Jia Y, Mu JC, Ackerman SL.
Cell. 2012 Jan 20;148(1-2):296-308
· Identification
of novel androgen-regulated pathways and mRNA isoforms through
genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan
P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
Leung HY, Elliott DJ.
PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14
· Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.
Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.
Human Molecular Genetics 2011, Jun 30
· Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
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· Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.
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Cancer Research 2010 Jan 26.
· Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.
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· Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.
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- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime
Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
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MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
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- Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer
Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina
Immunology. 2024 Jul 2 / 38953295
- Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer
Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette
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- Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development
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- A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner
Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele
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- BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance
Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Cancer Discov. 2023 Nov 1 / 37623817
- Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression
Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue
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- Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall
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- Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz
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- Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs
Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm
Front Mol Neurosci. 2023 May 5 / 37266374
- Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity
Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl
Cell Mol Life Sci. 2023 May 15 / 37184603
- Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology
Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel
Exp Dermatol. 2023 May 6 / 37148203
- CDK12/13 promote splicing of proximal introns by enhancing the
interaction between RNA polymerase II and the splicing factor SF3B1Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn
Nat Commun. 2023 Apr 1 / 37005415
- T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros
Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
- RELA tunes innate-like interferon I/III responses in human T cells
Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas ManelJ Exp Med. 2023 Feb 23 / 36820829
- Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc DupuisNat Commun. 2023 May 1/ 36670122
- Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca AmatiInt J Mol Sci. 2023 Jan 6 / 36674633
- Cortical wiring by synapse type-specific control of local protein synthesis
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar MarínScience. 2022 Nov 25 / 36423280
- The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-KourbaliBr J Cancer. 2022 Dec 22 / 36550208
- RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan StammNucleic Acids Res. 2022 Dec 19 / 36533443
- Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.
Olivier Ariste, Pierre de la Grange, Reiner A Veitia
Clin Genet. 2022 Nov 10 / PMID: 36353970
- Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger
EMBO J. 2022 Sep 23 / PMID: 36149731
- A conserved molecular template underlies color pattern diversity in estrildid finches.
Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau
Sci Adv. 2022 Sep 2 / PMID: 36044564
- RNF213-associated urticarial lesions with hypercytokinemia
Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
Irina GiurgeaJ Allergy Clin Immunol. 2022 Jun 30 / PMID: 35780935
- Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine
Aging. 2022 May 4 / PMID: 35507806
- Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm
Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2022 Mar 24 / PMID: 34905599
- Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway
Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin
Brain. 2022 Mar 17 / PMID: 35298632
- Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data
Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet
Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653
- CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1
Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu
Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489
- Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia
Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin
Brain. 2022 Jan 4 / PMID: 34983064
- The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
- Epithelial colonization by gut dendritic cells promotes their functional diversification
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil
Immunity. December 14, 2021
https://www.sciencedirect.com/science/article/pii/S1074761321004994
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2021 Dec 14 / PMID: 34905599
- BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua
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- Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
Leukemia Organization) group
- Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
Guido Kroemer, Jonathan G Pol
- Genes coding for transcription factors involved in stem cell
maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
COPD bronchial epithelial progenitors.
Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.
Mol Biol Rep. 2021 Aug 26 / PMID: 34436724
- Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.
Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.
Cereb Cortex. 2021 May 21 / PMID: 34023893
- Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
- Activation of Macrophages by Lysophosphatidic Acid through
the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
Sclerosis Pathogenesis.
Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.
Mol Neurobiol. 2021 Feb / PMID: 32974731
· Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.
Emmanuel
Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5
· Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.
Ben
Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
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· Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
with oligodendroglial hyperplasia in epilepsy (MOGHE)
Thomas
Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
Blumcke, Stéphanie Baulac
Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.
· Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?
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· Plasma microRNA signature in presymptomatic and symptomatic subjects with
C9orf72-associated frontotemporal dementia and amyotrophic lateral
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· Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.
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· Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Chiot
A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
Boillée S.
Nat Neurosci. 2020 Oct 19.
· Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.
Bogdan
Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos
Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.
· Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli
Cell Rep. 2020 Apr 14 / PMID: 32294449
· Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.
Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.
Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019
· Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.
Romagnoli
M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
MA, Glukhova MA, Faraldo MM.
Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552
· ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Gacem
N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.
Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5
· Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.
Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117
· An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Traoré
M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
Falcone S
Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131
· A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Lévesque
S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
Kroemer G, Pol JG
Oncoimmunology. 2019 Sep 7;8(11):e1657375
· SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.
Leman
R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S
Bioinformatics. 2019 Oct 16. pii: btz784
· Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Furlanis E, Traunmüller L, Fucile G, Scheiffele P.
Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5
· Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
Baldassari
S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
M, Baulac S
Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5
· Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression
Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S
Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861
· Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica
V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.
Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.
· Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
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P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.
Nat Commun. 2019 Apr 2;10(1):1486
· Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.
Romagnoli
M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
Raymond K, Glukhova MA, Faraldo MM.
Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6
· Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
differentiation-dependent metabolic responses to IFNG stimulation.
Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.
Cell Death Dis. 2019 Mar 20;10(4):277
· Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.
Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.
Cell Rep. 2019 Mar 12;26(11):2929-2941
· p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.
Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.
Breast Cancer Res. 2019 Jan 25;21(1):13
· Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.
Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.
Sci Rep. 2019 Jan 28;9(1):792
· Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.
Daruich
A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.
Sci Adv. 2019 Jan 9;5(1):eaau9940
· Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.
Domenech
C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.
Stem Cell Reports 2018, Nov 13;11(5):1075-1091
· The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.
Tury
S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
Lallemand F, Marangoni E, Bièche I, Callens C.
J Pathol. 2018 Jun 7
· Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.
Bruno,
A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
L, Rahimian, A, Lemoine, F, de la Grange, P, Guégan, J, Bielle, F,
Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
Mokhtari, K, Hoang-Xuan, K, Alentorn, A.
Neuro Oncol. 2018 Jul 5;20(8):1092-1100
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595.
· Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
Cifdaloz
M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
Megías D, Valcárcel J, Soengas MS.
Nat Commun. 2017 Dec 21;8(1):2249.
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595
· Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Glentis
A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
Plodinec M, Vignjevic DM.
Nat Commun. 2017 Oct 13;8(1):924.
· hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell
Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.
Nucleic Acids Res. 2017 Oct 3
· Neurotrophic factors for motor neurons: an à la carte menu
Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.
Med Sci (Paris). 2017 Oct;33(10):835-839
· Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.
Grégoire
Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
Alexandra Martins, Dominique Vaur, Sophie Krieger.
Eur J Hum Genet. 2017 Oct;25(10):1147-1154
· Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
and Sensitivity to the DNA Repair Inhibitor AsiDNA.
Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.
Cancer Res. 2017 Aug 15;77(16):4207-4216
· Pre-therapy liver transcriptome landscape in Indian and French patients with severe
alcoholic hepatitis and steroid responsiveness
Shvetank
Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
Richard Moreau & Shiv K. Sarin.
Scientific Reports 2017 Jul 28;7(1):6816
· Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.
Nucleic Acids Res. 2017 Jun 7
· Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.
Boulay
AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.
Cell Discov. 2017 Mar 28
· An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation
Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.
Developmental Cell 2017 Mar 24
· Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.
Proc Natl Acad Sci U S A. 2017 Mar 7
· Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo
J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,
Int J Obes (Lond). 2017
· Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.
Weiss
E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
Lotersztajn S, Moreau R.,
J Hepatol. 2016 Dec 28
· Deregulation of pre-messenger RNA splicing and rare diseases.
de la Grange P.
Med Sci (Paris). 2016 Dec
· Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Mauger O, Lemoine F, Scheiffele P.,
Neuron. 2016 Nov 21
· Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.
La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C
Elife. 2016 Nov 15
· Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
Neuronal Cultures.
Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C
Mol Neurobiol. 2016 Nov 14
· Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.
Møller
RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
G, Cooper GM, Baulac S.
Neurol Genet. 2016 Oct 31
· p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.
Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.
Oncogene. 2016 Oct 24
· Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D
Stem Cells Dev. 2016 Oct 17
· Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.
Klein
P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
Butler-Browne G, Bastide B, Mouly V, Trollet C.
Nucleic Acids Res. 2016 Aug 9
· Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.
Vallerand
D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
Savina A, Decaudin D.
PLoS One. 2016 Jul 7
· Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.
Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.
Mol Neurodegener. 2016 Jun
· Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
Weckhuysen
S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.
Epilepsia 2016 May 13.
· Control of neuronal synapse specification by a highly dedicated alternative splicing program
Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.
Science. 2016 May 12
· GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne
L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
Pla M, Fenaux P, Padua RA, Chomienne C, Krief P
Hematol Oncol. 2016 Jan 27
· Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
Associated with the Upregulation of Wingless-Related Integration and
Bone Morphogenetic Protein Signaling in Dark Agouti Rats.
Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.
Med Princ Pract. 2016
· Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study
Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,
Stem Cell Reports. 2015 Nov 11
· From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,
Biochim Biophys Acta. 2015 Oct 26.
· Developmental clock compromises human twin model created by embryo splitting
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,
Hum Reprod. 2015 Oct 21
· MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
and can be explored for human embryo reproductive competence assessment
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.
Fertil Steril. 2015 Oct 9
· Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
provide insights into tumor biology and therapeutic leads.
Auguste
A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
Galmiche L, Kalfa N, Veitia RA
Hum Mol Genet. 2015 Sep 11.
· TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.
NAR. 2015 Aug
· SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.
Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.
Gene, 2015 Jul.
· DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.
Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.
Blood. 2015 Apr 16
· Disruption of SF3B1 results in deregulated expression and splicing of key genes
and pathways in myelodysplastic syndrome hematopoietic stem and
progenitor cells
H
Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
1092–1103
· Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.
Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.
Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.
· Expression of the potential therapeutic target CXXC5 in primary acute myeloid
leukemia cells – high expression is associated with adverse prognosis as
well as altered intracellular signaling and transcriptional regulation.
Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.
Oncotarget. 2014 Dec 26
· Acquired resistance to endocrine treatments is associated to tumor-specific
molecular changes in patient-derived luminal breast cancer xenografts.
Cottu
PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
Roman-Roman S, Marangoni E.
Clin Cancer Res. 2014 Aug 15;20(16):4314-25.
· Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.
Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.
Cell Reports. 2014 May 10
· Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia
IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.
EMBO Rep., 2014 Mar 17
· RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.
Mol Cell. 2013 Dec
· Sudemycin E influences alternative splicing and changes chromatin modifications.
Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.
Nucleic Acids Res. 2014 Mar 11.
· A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer
Pesson
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Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.
PLoS One. 2014 Feb 6.
· A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
application to the study of genes involved in the response to targeted
anticancer therapies
Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.
Mol. Cancer, 2014 Jan.
· Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S
PLoS One. 2013 Dec.
· CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.
Astori
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Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
Lillehaug JR, Pendino F, Bruserud O
Oncotarget, 2013 Aug.
· BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
of AML by targeting primitive LSK and progenitor cells.
Beurlet
S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
West R, Fenaux P, Chomienne C, Padua RA.
Blood. 2013 Aug
· SF3B1 mutations are associated with alternative splicing in uveal melanoma.
Furney
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S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
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Cancer Discov. 2013 Jul 16
· Molecular characterization of a patient presumed to have prader-willi syndrome.
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.
Clin Med Insights Case Rep. 2013 May 10.
· Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.
Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.
Cell Reprogram. 2013 May 10.
· Genome
wide array analysis indicates that an amyotrophic lateral sclerosis
mutation of FUS causes an early increase of CAMK2N2 in vitro.
Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.
Biochim Biophys Acta. 2013 Mar
· Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.
Nucleic Acids Res. 2013 Feb 7.
· hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.
Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.
EMBO J. 2013 Feb 5. , DOI
· Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.
Sonia
Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
Renato C. Monteiro, Pierre de la Grange, Richard Moreau
J Hepatol. 2013 Jan 12. , DOI
· The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.
Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.
EMBO Mol Med. 2013 Jan 9. , DOI
· Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.
Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.
PLoS One. 2012;7(12):e51266. , DOI
· TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.
Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.
Oncogene. 2012 Nov 5. , DOI
· Argonaute proteins couple chromatin silencing to alternative splicing.
Ameyar-Zazoua
M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
C, Batsché E, Harel-Bellan A.
Nat Struct Mol Biol. 2012 Sep 9
· Lipocalin
2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
downstream of NFAT1 to regulate breast cancer cell invasion.
Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.
J Cell Sci. 2012 Jul 5.
· A transcriptome signature of endothelial lymphatic cells coexists with
the chronic oxidative stress signature in radiation-induced
post-radiotherapy breast angiosarcomas.
Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.
Carcinogenesis. 2012 May 7.,
· Sperm transcriptome profiling in oligozoospermia.
Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.
J Assist Reprod Genet. 2012 Jan;29(1):3-10
· Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.
Jia Y, Mu JC, Ackerman SL.
Cell. 2012 Jan 20;148(1-2):296-308
· Identification
of novel androgen-regulated pathways and mRNA isoforms through
genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan
P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
Leung HY, Elliott DJ.
PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14
· Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.
Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.
Human Molecular Genetics 2011, Jun 30
· Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Fugier
C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
Bassez G, Laporte J, Furling D, Charlet-Berguerand N.
Nat Med. 2011 May 29
· Melanoma
spheroids grown under neural crest cell conditions are highly plastic
migratory/invasive tumor cells endowed with immunomodulator function.
Ramgolam
K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R
PLoS One 2011;6(4):e18784
· Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.
Saint-André V, Batsché E, Rachez C, Muchardt C.
Nature Structural and Molecular Biology 2011, 18(3):337-44
· Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.
Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.
Nat Struct Mol Biol. 2010 Aug 15
· Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.
Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.
Cancer Research 2010 Apr 20.
· Splicing factor and exon profiling across human tissues.
de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.
Nucleic Acids Research. 2010 Jan 27.
· Exon-Based
Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
Exons Whose Expression Is Associated with Metastasis.
Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.
Cancer Research 2010 Jan 26.
· Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.
El-Bchiri
J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.
PLoS ONE. 2008, 3(7):e2583.
· Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.
Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.
Mol Cell Biol. 2007, 27(20):7315-33.
· A new advance in alternative splicing databases: from catalogue to
detailed analysis of regulation of expression and function of human
alternative splicing variants.
de la Grange P, Dutertre M, Correa M, Auboeuf D.
BMC Bioinformatics 2007, 8:180
· ASEtrap: a biological method for speeding up the exploration of spliceomes.
Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.
Genome Res. 2006, 16(6):776-86.
· FAST DB: a website resource for the study of the expression regulation of human gene products.
de la Grange P, Dutertre M, Martin N, Auboeuf D.
Nucleic Acids Research 2005, 33(13):4276-4284.
PMI
Eur J Hum Genet. 2022 Mar 11.
Brain. 2022 Mar 17
Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime
Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
- Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer
Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina
Immunology. 2024 Jul 2 / 38953295
- Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer
Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina
Immunology. 2024 Jul 2 / 38953295
- Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer
Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette
J Exp Clin Cancer Res. 2024 Feb 27 / 38413979
- Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development
Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette
Nucleic Acids Res. 2024 Feb 7 / 38324473
- A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner
Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele
Cell Rep. Mar 28 / 36862556
- BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance
Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Cancer Discov. 2023 Nov 1 / 37623817
- Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression
Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue
J Invest Dermatol. 2023 Sep 20 / 37739336
- Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall
Cell Rep. 2023 Sep 13 / 37708024
- Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz
JHEP Rep. 2023 May 16 / 37520673
- Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs
Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm
Front Mol Neurosci. 2023 May 5 / 37266374
- Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity
Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl
Cell Mol Life Sci. 2023 May 15 / 37184603
- Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology
Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel
Exp Dermatol. 2023 May 6 / 37148203
- CDK12/13 promote splicing of proximal introns by enhancing the
interaction between RNA polymerase II and the splicing factor SF3B1Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn
Nat Commun. 2023 Apr 1 / 37005415
- T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros
Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
- RELA tunes innate-like interferon I/III responses in human T cells
Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas ManelJ Exp Med. 2023 Feb 23 / 36820829
- Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc DupuisNat Commun. 2023 May 1/ 36670122
- Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca AmatiInt J Mol Sci. 2023 Jan 6 / 36674633
- Cortical wiring by synapse type-specific control of local protein synthesis
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar MarínScience. 2022 Nov 25 / 36423280
- The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-KourbaliBr J Cancer. 2022 Dec 22 / 36550208
- RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan StammNucleic Acids Res. 2022 Dec 19 / 36533443
- Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.
Olivier Ariste, Pierre de la Grange, Reiner A Veitia
Clin Genet. 2022 Nov 10 / PMID: 36353970
- Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger
EMBO J. 2022 Sep 23 / PMID: 36149731
- A conserved molecular template underlies color pattern diversity in estrildid finches.
Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau
Sci Adv. 2022 Sep 2 / PMID: 36044564
- RNF213-associated urticarial lesions with hypercytokinemia
Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
Nicolas Ortonne, Olivier Chosidow, Sonia A Karabina, Serge Amselem,
Irina GiurgeaJ Allergy Clin Immunol. 2022 Jun 30 / PMID: 35780935
- Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine
Aging. 2022 May 4 / PMID: 35507806
- Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm
Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2022 Mar 24 / PMID: 34905599
- Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway
Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin
Brain. 2022 Mar 17 / PMID: 35298632
- Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data
Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet
Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653
- CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1
Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu
Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489
- Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia
Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin
Brain. 2022 Jan 4 / PMID: 34983064
- The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
- Epithelial colonization by gut dendritic cells promotes their functional diversification
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil
Immunity. December 14, 2021
https://www.sciencedirect.com/science/article/pii/S1074761321004994
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2021 Dec 14 / PMID: 34905599
- BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua
Int J Mol Sci. 2021 Sep 30 / PMID: 34638998
- Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
Leukemia Organization) group
- Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
Guido Kroemer, Jonathan G Pol
- Genes coding for transcription factors involved in stem cell
maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
COPD bronchial epithelial progenitors.
Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.
Mol Biol Rep. 2021 Aug 26 / PMID: 34436724
- Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.
Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.
Cereb Cortex. 2021 May 21 / PMID: 34023893
- Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
- Activation of Macrophages by Lysophosphatidic Acid through
the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
Sclerosis Pathogenesis.
Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.
Mol Neurobiol. 2021 Feb / PMID: 32974731
· Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.
Emmanuel
Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5
· Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.
Ben
Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
10.1007/s12015-021-10123-z.
· Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
with oligodendroglial hyperplasia in epilepsy (MOGHE)
Thomas
Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
Blumcke, Stéphanie Baulac
Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.
· Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?
Lerebours
F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.
J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.
· Plasma microRNA signature in presymptomatic and symptomatic subjects with
C9orf72-associated frontotemporal dementia and amyotrophic lateral
sclerosis.
Kmetzsch
V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.
J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.
· Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.
Casulleras
M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
Moreau R, Arroyo V, Clària J.
Sci Transl Med. 2020 Oct 21;12(566):eaax5135.
· Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Chiot
A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
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Nat Neurosci. 2020 Oct 19.
· Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.
Bogdan
Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos
Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.
· Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli
Cell Rep. 2020 Apr 14 / PMID: 32294449
· Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.
Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.
Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019
· Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.
Romagnoli
M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
MA, Glukhova MA, Faraldo MM.
Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552
· ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Gacem
N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.
Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5
· Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.
Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117
· An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Traoré
M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
Falcone S
Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131
· A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Lévesque
S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
Kroemer G, Pol JG
Oncoimmunology. 2019 Sep 7;8(11):e1657375
· SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.
Leman
R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S
Bioinformatics. 2019 Oct 16. pii: btz784
· Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Furlanis E, Traunmüller L, Fucile G, Scheiffele P.
Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5
· Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
Baldassari
S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
M, Baulac S
Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5
· Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression
Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S
Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861
· Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica
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Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.
Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.
· Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
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Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.
Nat Commun. 2019 Apr 2;10(1):1486
· Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.
Romagnoli
M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
Raymond K, Glukhova MA, Faraldo MM.
Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6
· Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
differentiation-dependent metabolic responses to IFNG stimulation.
Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.
Cell Death Dis. 2019 Mar 20;10(4):277
· Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.
Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.
Cell Rep. 2019 Mar 12;26(11):2929-2941
· p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.
Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.
Breast Cancer Res. 2019 Jan 25;21(1):13
· Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.
Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.
Sci Rep. 2019 Jan 28;9(1):792
· Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.
Daruich
A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.
Sci Adv. 2019 Jan 9;5(1):eaau9940
· Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.
Domenech
C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.
Stem Cell Reports 2018, Nov 13;11(5):1075-1091
· The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.
Tury
S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
Lallemand F, Marangoni E, Bièche I, Callens C.
J Pathol. 2018 Jun 7
· Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.
Bruno,
A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
L, Rahimian, A, Lemoine, F, de la Grange, P, Guégan, J, Bielle, F,
Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
Mokhtari, K, Hoang-Xuan, K, Alentorn, A.
Neuro Oncol. 2018 Jul 5;20(8):1092-1100
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595.
· Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
Cifdaloz
M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
Megías D, Valcárcel J, Soengas MS.
Nat Commun. 2017 Dec 21;8(1):2249.
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595
· Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Glentis
A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
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Nat Commun. 2017 Oct 13;8(1):924.
· hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell
Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.
Nucleic Acids Res. 2017 Oct 3
· Neurotrophic factors for motor neurons: an à la carte menu
Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.
Med Sci (Paris). 2017 Oct;33(10):835-839
· Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.
Grégoire
Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
Alexandra Martins, Dominique Vaur, Sophie Krieger.
Eur J Hum Genet. 2017 Oct;25(10):1147-1154
· Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
and Sensitivity to the DNA Repair Inhibitor AsiDNA.
Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.
Cancer Res. 2017 Aug 15;77(16):4207-4216
· Pre-therapy liver transcriptome landscape in Indian and French patients with severe
alcoholic hepatitis and steroid responsiveness
Shvetank
Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
Richard Moreau & Shiv K. Sarin.
Scientific Reports 2017 Jul 28;7(1):6816
· Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.
Nucleic Acids Res. 2017 Jun 7
· Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.
Boulay
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Cell Discov. 2017 Mar 28
· An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation
Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.
Developmental Cell 2017 Mar 24
· Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.
Proc Natl Acad Sci U S A. 2017 Mar 7
· Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo
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S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
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· Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.
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Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
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J Hepatol. 2016 Dec 28
· Deregulation of pre-messenger RNA splicing and rare diseases.
de la Grange P.
Med Sci (Paris). 2016 Dec
· Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Mauger O, Lemoine F, Scheiffele P.,
Neuron. 2016 Nov 21
· Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.
La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C
Elife. 2016 Nov 15
· Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
Neuronal Cultures.
Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C
Mol Neurobiol. 2016 Nov 14
· Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.
Møller
RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
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Neurol Genet. 2016 Oct 31
· p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.
Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.
Oncogene. 2016 Oct 24
· Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D
Stem Cells Dev. 2016 Oct 17
· Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.
Klein
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L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
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Nucleic Acids Res. 2016 Aug 9
· Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.
Vallerand
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Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
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PLoS One. 2016 Jul 7
· Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.
Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.
Mol Neurodegener. 2016 Jun
· Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
Weckhuysen
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Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
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Epilepsia 2016 May 13.
· Control of neuronal synapse specification by a highly dedicated alternative splicing program
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Science. 2016 May 12
· GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne
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Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
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Hematol Oncol. 2016 Jan 27
· Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
Associated with the Upregulation of Wingless-Related Integration and
Bone Morphogenetic Protein Signaling in Dark Agouti Rats.
Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.
Med Princ Pract. 2016
· Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study
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Stem Cell Reports. 2015 Nov 11
· From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
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Biochim Biophys Acta. 2015 Oct 26.
· Developmental clock compromises human twin model created by embryo splitting
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,
Hum Reprod. 2015 Oct 21
· MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
and can be explored for human embryo reproductive competence assessment
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.
Fertil Steril. 2015 Oct 9
· Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
provide insights into tumor biology and therapeutic leads.
Auguste
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E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
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Hum Mol Genet. 2015 Sep 11.
· TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
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NAR. 2015 Aug
· SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.
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Gene, 2015 Jul.
· DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.
Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.
Blood. 2015 Apr 16
· Disruption of SF3B1 results in deregulated expression and splicing of key genes
and pathways in myelodysplastic syndrome hematopoietic stem and
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· Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.
Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.
Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.
· Expression of the potential therapeutic target CXXC5 in primary acute myeloid
leukemia cells – high expression is associated with adverse prognosis as
well as altered intracellular signaling and transcriptional regulation.
Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.
Oncotarget. 2014 Dec 26
· Acquired resistance to endocrine treatments is associated to tumor-specific
molecular changes in patient-derived luminal breast cancer xenografts.
Cottu
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Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
Roman-Roman S, Marangoni E.
Clin Cancer Res. 2014 Aug 15;20(16):4314-25.
· Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.
Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.
Cell Reports. 2014 May 10
· Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia
IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.
EMBO Rep., 2014 Mar 17
· RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.
Mol Cell. 2013 Dec
· Sudemycin E influences alternative splicing and changes chromatin modifications.
Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.
Nucleic Acids Res. 2014 Mar 11.
· A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer
Pesson
M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.
PLoS One. 2014 Feb 6.
· A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
application to the study of genes involved in the response to targeted
anticancer therapies
Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.
Mol. Cancer, 2014 Jan.
· Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S
PLoS One. 2013 Dec.
· CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.
Astori
A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
Lillehaug JR, Pendino F, Bruserud O
Oncotarget, 2013 Aug.
· BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
of AML by targeting primitive LSK and progenitor cells.
Beurlet
S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
West R, Fenaux P, Chomienne C, Padua RA.
Blood. 2013 Aug
· SF3B1 mutations are associated with alternative splicing in uveal melanoma.
Furney
SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
R.
Cancer Discov. 2013 Jul 16
· Molecular characterization of a patient presumed to have prader-willi syndrome.
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.
Clin Med Insights Case Rep. 2013 May 10.
· Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.
Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.
Cell Reprogram. 2013 May 10.
· Genome
wide array analysis indicates that an amyotrophic lateral sclerosis
mutation of FUS causes an early increase of CAMK2N2 in vitro.
Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.
Biochim Biophys Acta. 2013 Mar
· Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.
Nucleic Acids Res. 2013 Feb 7.
· hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.
Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.
EMBO J. 2013 Feb 5. , DOI
· Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.
Sonia
Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
Renato C. Monteiro, Pierre de la Grange, Richard Moreau
J Hepatol. 2013 Jan 12. , DOI
· The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.
Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.
EMBO Mol Med. 2013 Jan 9. , DOI
· Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.
Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.
PLoS One. 2012;7(12):e51266. , DOI
· TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.
Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.
Oncogene. 2012 Nov 5. , DOI
· Argonaute proteins couple chromatin silencing to alternative splicing.
Ameyar-Zazoua
M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
C, Batsché E, Harel-Bellan A.
Nat Struct Mol Biol. 2012 Sep 9
· Lipocalin
2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
downstream of NFAT1 to regulate breast cancer cell invasion.
Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.
J Cell Sci. 2012 Jul 5.
· A transcriptome signature of endothelial lymphatic cells coexists with
the chronic oxidative stress signature in radiation-induced
post-radiotherapy breast angiosarcomas.
Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.
Carcinogenesis. 2012 May 7.,
· Sperm transcriptome profiling in oligozoospermia.
Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.
J Assist Reprod Genet. 2012 Jan;29(1):3-10
· Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.
Jia Y, Mu JC, Ackerman SL.
Cell. 2012 Jan 20;148(1-2):296-308
· Identification
of novel androgen-regulated pathways and mRNA isoforms through
genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan
P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
Leung HY, Elliott DJ.
PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14
· Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.
Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.
Human Molecular Genetics 2011, Jun 30
· Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Fugier
C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
Bassez G, Laporte J, Furling D, Charlet-Berguerand N.
Nat Med. 2011 May 29
· Melanoma
spheroids grown under neural crest cell conditions are highly plastic
migratory/invasive tumor cells endowed with immunomodulator function.
Ramgolam
K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R
PLoS One 2011;6(4):e18784
· Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.
Saint-André V, Batsché E, Rachez C, Muchardt C.
Nature Structural and Molecular Biology 2011, 18(3):337-44
· Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.
Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.
Nat Struct Mol Biol. 2010 Aug 15
· Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.
Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.
Cancer Research 2010 Apr 20.
· Splicing factor and exon profiling across human tissues.
de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.
Nucleic Acids Research. 2010 Jan 27.
· Exon-Based
Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
Exons Whose Expression Is Associated with Metastasis.
Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.
Cancer Research 2010 Jan 26.
· Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.
El-Bchiri
J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.
PLoS ONE. 2008, 3(7):e2583.
· Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.
Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.
Mol Cell Biol. 2007, 27(20):7315-33.
· A new advance in alternative splicing databases: from catalogue to
detailed analysis of regulation of expression and function of human
alternative splicing variants.
de la Grange P, Dutertre M, Correa M, Auboeuf D.
BMC Bioinformatics 2007, 8:180
· ASEtrap: a biological method for speeding up the exploration of spliceomes.
Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.
Genome Res. 2006, 16(6):776-86.
· FAST DB: a website resource for the study of the expression regulation of human gene products.
de la Grange P, Dutertre M, Martin N, Auboeuf D.
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PMI
Eur J Hum Genet. 2022 Mar 11.
Brain. 2022 Mar 17
Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime
Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
- Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer
Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina
Immunology. 2024 Jul 2 / 38953295
- Erythropoietin induces tumour progression and CD39 expression on immune cells in a preclinical model of triple-negative breast cancer
Stéphanie Bessoles, Andrada Chiron, Guillaume Sarrabayrouse, Pierre De La Grange, Amine M Abina, Salima Hacein-Bey-Abina
Immunology. 2024 Jul 2 / 38953295
- Splicing targeting drugs highlight intron retention as an actionable vulnerability in advanced prostate cancer
Chiara Naro, Ambra Antonioni, Vanessa Medici, Cinzia Caggiano, Ariane Jolly, Pierre de la Grange, Pamela Bielli, Maria Paola Paronetto, Claudio Sette
J Exp Clin Cancer Res. 2024 Feb 27 / 38413979
- Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development
Eleonora Cesari, Donatella Farini, Vanessa Medici, Ingrid Ehrmann, Marika Guerra, Erika Testa, Chiara Naro, Maria Concetta Geloso, Vittoria Pagliarini, Livia La Barbera, Marcello D’Amelio, Tiziana Orsini, Stefano Farioli Vecchioli, Luca Tamagnone, Philippe Fort, Maria Teresa Viscomi, David J Elliott, Claudio Sette
Nucleic Acids Res. 2024 Feb 7 / 38324473
- A cell-type-specific alternative splicing regulator shapes synapse properties in a trans-synaptic manner
Lisa Traunmüller, Jan Schulz, Raul Ortiz, Huijuan Feng, Elisabetta Furlanis, Andrea M Gomez, Dietmar Schreiner, Josef Bischofberger, Chaolin Zhang, Peter Scheiffele
Cell Rep. Mar 28 / 36862556
- BCL2 Inhibition Reveals a Dendritic Cell-Specific Immune Checkpoint That Controls Tumor Immunosurveillance
Liwei Zhao, Peng Liu, Misha Mao, Shuai Zhang, Camille Bigenwald, Charles-Antoine Dutertre, Christian H K Lehmann, Hui Pan, Nicolas Paulhan, Lukas Amon, Aitziber Buqué, Takahiro Yamazaki, Lorenzo Galluzzi, Benoit Kloeckner, Aymeric Silvin, Yuhong Pan, Hui Chen, Ai-Ling Tian, Pierre Ly, Diana Dudziak, Laurence Zitvogel, Oliver Kepp, Guido Kroemer
Cancer Discov. 2023 Nov 1 / 37623817
- Loss of Dicer in newborn melanocytes leads to premature hair greying and changes in integrin expression
Juliette U Bertrand, Valérie Petit, Zackie Aktary, Pierre DE LA Grange, Nadav Elkoshi, Pierre Sohier, Véronique Delmas, Carmit Levy, Lionel Larue
J Invest Dermatol. 2023 Sep 20 / 37739336
- Multi-omics comparison of malignant and normal uveal melanocytes reveals molecular features of uveal melanoma
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J Waterfall
Cell Rep. 2023 Sep 13 / 37708024
- Monoacylglycerol lipase reprograms hepatocytes and macrophages to promote liver regeneration
Manon Allaire, Rola Al Sayegh, Morgane Mabire, Adel Hammoutene, Matthieu Siebert, Charles Caër, Mathilde Cadoux, JingHong Wan, Aida Habib, Maude Le Gall, Pierre de la Grange, Hervé Guillou, Catherine Postic, Valérie Paradis, Sophie Lotersztajn, Hélène Gilgenkrantz
JHEP Rep. 2023 May 16 / 37520673
- Alzheimer’s disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs
Karol Andrea Arizaca Maquera, Justin Ralph Welden, Giorgi Margvelani, Sandra C Miranda Sardón, Samantha Hart, Noémie Robil, Alvaro Gonzalo Hernandez, Pierre de la Grange, Peter T Nelson, Stefan Stamm
Front Mol Neurosci. 2023 May 5 / 37266374
- Neurofilament accumulations in amyotrophic lateral sclerosis patients’ motor neurons impair axonal initial segment integrity
Cynthia Lefebvre-Omar, Elise Liu, Carine Dalle, Boris Lamotte d’Incamps, Stéphanie Bigou, Clément Daube, Léa Karpf, Marc Davenne, Noémie Robil, Coline Jost Mousseau, Stéphane Blanchard, Guillaume Tournaire, Charles Nicaise, François Salachas, Lucette Lacomblez, Danielle Seilhean, Christian S Lobsiger, Stéphanie Millecamps, Séverine Boillée, Delphine Bohl
Cell Mol Life Sci. 2023 May 15 / 37184603
- Evidence of inter- and intra-keloid heterogeneity through analysis of dermal fibroblasts: A new insight in deciphering keloid physiopathology
Kévin Serror, Lauren Ferrero, Françoise Boismal, Maxime Sintes, Manuel Thery, Benoit Vianay, Emilie Henry, David Gentien, Pierre DE LA Grange, David Boccara, Maurice Mimoun, Jean-David Bouaziz, Armand Benssussan, Laurence Michel
Exp Dermatol. 2023 May 6 / 37148203
- CDK12/13 promote splicing of proximal introns by enhancing the
interaction between RNA polymerase II and the splicing factor SF3B1Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- CDK12/13 promote splicing of proximal introns by enhancing the interaction between RNA polymerase II and the splicing factor SF3B1
Valentina Panzeri, Marco Pieraccioli, Eleonora Cesari, Pierre de la Grange, Claudio Sette
Nucleic Acids Res. 2023 Apr 7 / 37026485
- MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
Morgane Mabire, Pushpa Hegde, Adel Hammoutene, Jinghong Wan, Charles Caër, Rola Al Sayegh, Mathilde Cadoux, Manon Allaire, Emmanuel Weiss, Tristan Thibault-Sogorb, Olivier Lantz, Michèle Goodhardt, Valérie Paradis, Pierre de la Grange, Hélène Gilgenkrantz, Sophie Lotersztajn
Nat Commun. 2023 Apr 1 / 37005415
- T-cell dysregulation and inflammatory process in Gcn2 (Eif2ak4-/-) deficient rats in basal and stress conditions
Juliette Bignard, Fabrice Atassi, Olivier Claude, Maria-Rosa Ghigna, Nathalie Mougenot, Bahgat Soilih Abdoulkarim, Florence Deknuydt, Aurélie Gestin, Virginie Monceau, David Montani, Sophie Nadaud, Florent Soubrier, Frédéric Perros
Am J Physiol Lung Cell Mol Physiol. 2023 Feb 28 / 36852942
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell, Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain, Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
- RELA tunes innate-like interferon I/III responses in human T cells
Nadia Jeremiah 1, Hermine Ferran, Konstantina Antoniadou, Kevin De Azevedo, Jovan Nikolic, Mathieu Maurin, Philippe Benaroch, Nicolas ManelJ Exp Med. 2023 Feb 23 / 36820829
- Integrative genetic analysis illuminates ALS heritability and identifies risk genes
Salim Megat, Natalia Mora, Jason Sanogo, Olga Roman, Alberto Catanese, Najwa Ouali Alami, Axel Freischmidt, Xhuljana Mingaj, Hortense De Calbiac, François Muratet, Sylvie Dirrig-Grosch, Stéphane Dieterle, Nick Van Bakel, Kathrin Müller, Kirsten Sieverding, Jochen Weishaupt, Peter Munch Andersen, Markus Weber, Christoph Neuwirth, Markus Margelisch, Andreas Sommacal, Kristel R Van Eijk, Jan H Veldink, Project Mine Als Sequencing Consortium, Géraldine Lautrette, Philippe Couratier, Agnès Camuzat, Isabelle Le Ber, Maurizio Grassano, Adriano Chio, Tobias Boeckers, Albert C Ludolph, Francesco Roselli, Deniz Yilmazer-Hanke, Stéphanie Millecamps, Edor Kabashi, Erik Storkebaum, Chantal Sellier, Luc DupuisNat Commun. 2023 May 1/ 36670122
- Downregulation of Circulating Hsa-miR-200c-3p Correlates with Dyslipidemia in Patients with Stable Coronary Artery Disease
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-GodChiara Vancheri, Elena Morini, Francesca Romana Prandi, Francesco Barillà, Francesco Romeo, Giuseppe Novelli, Francesca AmatiInt J Mol Sci. 2023 Jan 6 / 36674633
- Cortical wiring by synapse type-specific control of local protein synthesis
Clémence Bernard, David Exposito-Alonso, Martijn Selten, Stella Sanalidou, Alicia Hanusz-Godoy, Alfonso Aguilera, Fursham Hamid, Fazal Oozeer, Patricia Maeso, Leanne Allison, Matthew Russell, Roland A Fleck, Beatriz Rico, Oscar MarínScience. 2022 Nov 25 / 36423280
- The Neuropilin-1/PKC axis promotes neuroendocrine differentiation and drug resistance of prostate cancer
Charly Blanc, Anissa Moktefi, Ariane Jolly, Pierre de la Grange, Denise Gay, Nathalie Nicolaiew, Fannie Semprez, Pascale Maillé, Pascale Soyeux, Virginie Firlej, Francis Vacherot, Damien Destouches, Mohamed Amiche, Stéphane Terry, Alexandre de la Taille, Arturo Londoño-Vallejo, Yves Allory, Jean Delbé, Yamina Hamma-KourbaliBr J Cancer. 2022 Dec 22 / 36550208
- RNA editing of microtubule-associated protein tau circular RNAs promotes their translation and tau tangle formation
Justin Ralph Welden, Giorgi Margvelani, Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti, Sandra C Miranda Sardón, Alexandre Rosa Campos, Noémie Robil, Daniel C Lee, Alvaro G Hernandez, Wang-Xia Wang, Jing Di, Pierre de la Grange, Peter T Nelson, Stefan StammNucleic Acids Res. 2022 Dec 19 / 36533443
- Recurrent missense variants in clonal hematopoiesis-related genes present in the general population.
Olivier Ariste, Pierre de la Grange, Reiner A Veitia
Clin Genet. 2022 Nov 10 / PMID: 36353970
- Stimulus-specific remodeling of the neuronal transcriptome through nuclear intron-retaining transcripts.
Maxime Mazille , Katarzyna Buczak, Peter Scheiffele, Oriane Mauger
EMBO J. 2022 Sep 23 / PMID: 36149731
- A conserved molecular template underlies color pattern diversity in estrildid finches.
Magdalena Hidalgo, Camille Curantz, Nicole Quenech’Du, Julia Neguer, Samantha Beck, Ammara Mohammad, Marie Manceau
Sci Adv. 2022 Sep 2 / PMID: 36044564
- RNF213-associated urticarial lesions with hypercytokinemia
Camille Louvrier, Fawaz Awad, Anne Cosnes, Elma El Khouri, Eman
Assrawi, Aphrodite Daskalopoulou, Bruno Copin, Hélène Bocquet, Sandra
Chantot Bastaraud, Angela Arenas Garcia, Florence Dastot Le Moal, Pierre
De La Grange, Philippe Duquesnoy, Chiara I Guerrera, William Piterboth,
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Irina GiurgeaJ Allergy Clin Immunol. 2022 Jun 30 / PMID: 35780935
- Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
Aleksandra Savina, Thierry Jaffredo, Frederic Saldmann, Chris G Faulkes, Philippe Moguelet, Christine Leroy, Delphine Del Marmol, Patrice Codogno, Lucy Foucher, Antoine Zalc, Mélanie Viltard, Gérard Friedlander, Selim Aractingi, Romain H Fontaine
Aging. 2022 May 4 / PMID: 35507806
- Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Samantha N Hart, Samir P Patel, Felicia M Michael, Peter Stoilov, Chi Jing Leow, Alvaro G Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G Rabchevsky, Stefan Stamm
Neurotrauma Rep. 2022 Mar 4 / PMID: 35403103
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing, and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Hélène Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins-Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2022 Mar 24 / PMID: 34905599
- Reactive astrocytes promote proteostasis in Huntington’s disease through the JAK2-STAT3 pathway
Laurene Abjean, Lucile Ben Haim, Miriam Riquelme-Perez, Pauline Gipchtein, Céline Derbois, Marie-Ange Palomares, Fanny Petit, Anne-Sophie Hérard, Marie-Claude Gaillard, Martine Guillermier, Mylène Gaudin-Guérif, Gwennaëlle Aurégan, Nisrine Sagar, Cameron Héry, Noëlle Dufour, Noémie Robil, Mehdi Kabani, Ronald Melki, Pierre De la Grange, Alexis P Bemelmans, Gilles Bonvento, Jean-François Deleuze, Philippe Hantraye, Julien Flament, Eric Bonnet, Solène Brohard, Robert Olaso, Emmanuel Brouillet, Maria-Angeles Carrillo-de Sauvage, Carole Escartin
Brain. 2022 Mar 17 / PMID: 35298632
- Detection of a pathogenic Alu element insertion in PALB2 gene from targeted NGS diagnostic data
Mélanie Eyries, Olivier Ariste, Gaelle Legrand, Noémie Basset, Erell Guillerm, Alexandre Perrier, Caroline Duros, Odile Cohen-Haguenauer, Pierre de la Grange, Florence Coulet
Eur J Hum Genet. 2022 Mar 11 / PMID: 35277653
- CAR T-cell Entry into Tumor Islets Is a Two-Step Process Dependent on IFNγ and ICAM-1
Chahrazade Kantari-Mimoun, Sarah Barrin, Lene Vimeux, Sandrine Haghiri, Claire Gervais, Sandy Joaquina, Joerg Mittelstaet, Nadine Mockel-Tenbrinck, Ali Kinkhabwala, Diane Damotte, Audrey Lupo, Mathilde Sibony, Marco Alifano, Elisabetta Dondi, Nadège Bercovici, Alain Trautmann, Andrew D Kaiser, Emmanuel Donnadieu
Cancer Immunol Res. 2021 Dec 9 / PMID: 34686489
- Clinical and genetic spectra of 1550 index patients with hereditary spastic paraplegia
Jean-Loup Méreaux, Guillaume Banneau, Mélanie Papin, Giulia Coarelli, Rémi Valter, Laure Raymond, Bophara Kol, Olivier Ariste, Livia Parodi, Laurène Tissier, Mathilde Mairey, Samia Ait Said, Celia Gautier, Marine Guillaud-Bataille, French SPATAX clinical network; Sylvie Forlani, Pierre de la Grange, Alexis Brice, Giovanni Vazza, Alexandra Durr, Eric Leguern, Giovanni Stevanin
Brain. 2022 Jan 4 / PMID: 34983064
- The oncogenic kinase NEK2 regulates an RBFOX2-dependent pro-mesenchymal splicing program in triple-negative breast cancer cells
- Epithelial colonization by gut dendritic cells promotes their functional diversification
Claudia A. Rivera, Violaine Randrian, Wilfrid Richer, Yohan Gerber-Ferder, Maria-Graciela Delgado, Aleksandra S. Chikina, Annika Frede, Chiara Sorini, Mathieu Maurin, Hana Kammoun-Chaari, Sara M. Parigi, Christel Goudot, Mar Cabeza-Cabrerizo, Sylvain Baulande, Sonia Lameiras, Pierre Guermonprez, Caetano Reis e Sousa, Marc Lecuit, Hélène D. Moreau, Julie Helft, Danijela Matic Vignjevic, Eduardo J. Villablanca, Ana-Maria Lennon-Duménil
Immunity. December 14, 2021
https://www.sciencedirect.com/science/article/pii/S1074761321004994
- Macrophage-derived CXCL9 and CXCL11, T-cell skin homing and disease control in mogamulizumab-treated CTCL patients
Adèle de Masson, Delphine Darbord, Gabor Dobos, Marie Boisson, Marie Roelens, Caroline Ram-Wolff, Charles Cassius, Helene Le Buanec, Pierre de la Grange, Fanélie Jouenne, Baptiste Louveau, Aurélie Sadoux, Jean-David Bouaziz, Anne Marie-Cardine, Martine Bagot, Hélène Moins Teisserenc, Samia Mourah, Maxime Battistella
Blood. 2021 Dec 14 / PMID: 34905599
- BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Petra Gorombei, Fabien Guidez, Saravanan Ganesan, Mathieu Chiquet, Andrea Pellagatti, Laure Goursaud, Nilgun Tekin, Stephanie Beurlet, Satyananda Patel, Laura Guerenne, Carole Le Pogam, Niclas Setterblad, Pierre de la Grange, Christophe LeBoeuf, Anne Janin, Maria-Elena Noguera, Laure Sarda-Mantel, Pascale Merlet, Jacqueline Boultwood, Marina Konopleva, Michael Andreeff, Robert West, Marika Pla, Lionel Adès, Pierre Fenaux, Patricia Krief, Christine Chomienne, Nader Omidvar, Rose Ann Padua
Int J Mol Sci. 2021 Sep 30 / PMID: 34638998
- Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
Leukemia Organization) group
- Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
Guido Kroemer, Jonathan G Pol
- Genes coding for transcription factors involved in stem cell
maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
COPD bronchial epithelial progenitors.
Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.
Mol Biol Rep. 2021 Aug 26 / PMID: 34436724
- Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.
Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.
Cereb Cortex. 2021 May 21 / PMID: 34023893
- Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
- Activation of Macrophages by Lysophosphatidic Acid through
the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
Sclerosis Pathogenesis.
Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.
Mol Neurobiol. 2021 Feb / PMID: 32974731
· Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.
Emmanuel
Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5
· Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.
Ben
Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
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· Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
with oligodendroglial hyperplasia in epilepsy (MOGHE)
Thomas
Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
Blumcke, Stéphanie Baulac
Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.
· Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?
Lerebours
F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.
J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.
· Plasma microRNA signature in presymptomatic and symptomatic subjects with
C9orf72-associated frontotemporal dementia and amyotrophic lateral
sclerosis.
Kmetzsch
V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.
J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.
· Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.
Casulleras
M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
Moreau R, Arroyo V, Clària J.
Sci Transl Med. 2020 Oct 21;12(566):eaax5135.
· Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Chiot
A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
Boillée S.
Nat Neurosci. 2020 Oct 19.
· Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.
Bogdan
Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos
Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.
· Cell Metabolic Alterations due to Mcph1 Mutation in Microcephaly.
Nathalie Journiac, Javier Gilabert-Juan, Sara Cipriani, Paule Benit, Xiaoqian Liu, Sandrine Jacquier, Valérie Faivre, Andrée Delahaye-Duriez, Zsolt Csaba, Tristan Hourcade, Eliza Melinte, Sophie Lebon, Céline Violle-Poirsier, Jean-François Oury, Homa Adle-Biassette, Zhao-Qi Wang, Shyamala Mani, Pierre Rustin, Pierre Gressens, Jeannette Nardelli
Cell Rep. 2020 Apr 14 / PMID: 32294449
· Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.
Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.
Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019
· Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.
Romagnoli
M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
MA, Glukhova MA, Faraldo MM.
Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552
· ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Gacem
N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.
Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5
· Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.
Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117
· An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Traoré
M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
Falcone S
Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131
· A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Lévesque
S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
Kroemer G, Pol JG
Oncoimmunology. 2019 Sep 7;8(11):e1657375
· SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.
Leman
R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S
Bioinformatics. 2019 Oct 16. pii: btz784
· Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Furlanis E, Traunmüller L, Fucile G, Scheiffele P.
Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5
· Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
Baldassari
S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
M, Baulac S
Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5
· Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression
Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S
Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861
· Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica
V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.
Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.
· Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
Liu
P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C,
Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.
Nat Commun. 2019 Apr 2;10(1):1486
· Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.
Romagnoli
M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
Raymond K, Glukhova MA, Faraldo MM.
Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6
· Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
differentiation-dependent metabolic responses to IFNG stimulation.
Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.
Cell Death Dis. 2019 Mar 20;10(4):277
· Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.
Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.
Cell Rep. 2019 Mar 12;26(11):2929-2941
· p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.
Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.
Breast Cancer Res. 2019 Jan 25;21(1):13
· Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.
Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.
Sci Rep. 2019 Jan 28;9(1):792
· Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.
Daruich
A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.
Sci Adv. 2019 Jan 9;5(1):eaau9940
· Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.
Domenech
C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.
Stem Cell Reports 2018, Nov 13;11(5):1075-1091
· The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.
Tury
S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
Lallemand F, Marangoni E, Bièche I, Callens C.
J Pathol. 2018 Jun 7
· Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.
Bruno,
A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
L, Rahimian, A, Lemoine, F, de la Grange, P, Guégan, J, Bielle, F,
Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
Mokhtari, K, Hoang-Xuan, K, Alentorn, A.
Neuro Oncol. 2018 Jul 5;20(8):1092-1100
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595.
· Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
Cifdaloz
M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
Megías D, Valcárcel J, Soengas MS.
Nat Commun. 2017 Dec 21;8(1):2249.
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595
· Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Glentis
A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
Plodinec M, Vignjevic DM.
Nat Commun. 2017 Oct 13;8(1):924.
· hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell
Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.
Nucleic Acids Res. 2017 Oct 3
· Neurotrophic factors for motor neurons: an à la carte menu
Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.
Med Sci (Paris). 2017 Oct;33(10):835-839
· Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.
Grégoire
Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
Alexandra Martins, Dominique Vaur, Sophie Krieger.
Eur J Hum Genet. 2017 Oct;25(10):1147-1154
· Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
and Sensitivity to the DNA Repair Inhibitor AsiDNA.
Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.
Cancer Res. 2017 Aug 15;77(16):4207-4216
· Pre-therapy liver transcriptome landscape in Indian and French patients with severe
alcoholic hepatitis and steroid responsiveness
Shvetank
Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
Richard Moreau & Shiv K. Sarin.
Scientific Reports 2017 Jul 28;7(1):6816
· Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.
Nucleic Acids Res. 2017 Jun 7
· Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.
Boulay
AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.
Cell Discov. 2017 Mar 28
· An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation
Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.
Developmental Cell 2017 Mar 24
· Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.
Proc Natl Acad Sci U S A. 2017 Mar 7
· Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo
J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
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· Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.
Weiss
E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
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J Hepatol. 2016 Dec 28
· Deregulation of pre-messenger RNA splicing and rare diseases.
de la Grange P.
Med Sci (Paris). 2016 Dec
· Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Mauger O, Lemoine F, Scheiffele P.,
Neuron. 2016 Nov 21
· Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.
La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C
Elife. 2016 Nov 15
· Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
Neuronal Cultures.
Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C
Mol Neurobiol. 2016 Nov 14
· Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.
Møller
RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
G, Cooper GM, Baulac S.
Neurol Genet. 2016 Oct 31
· p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.
Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.
Oncogene. 2016 Oct 24
· Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D
Stem Cells Dev. 2016 Oct 17
· Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.
Klein
P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
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Nucleic Acids Res. 2016 Aug 9
· Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.
Vallerand
D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
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PLoS One. 2016 Jul 7
· Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.
Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.
Mol Neurodegener. 2016 Jun
· Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
Weckhuysen
S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
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Epilepsia 2016 May 13.
· Control of neuronal synapse specification by a highly dedicated alternative splicing program
Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.
Science. 2016 May 12
· GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne
L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
Pla M, Fenaux P, Padua RA, Chomienne C, Krief P
Hematol Oncol. 2016 Jan 27
· Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
Associated with the Upregulation of Wingless-Related Integration and
Bone Morphogenetic Protein Signaling in Dark Agouti Rats.
Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.
Med Princ Pract. 2016
· Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study
Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,
Stem Cell Reports. 2015 Nov 11
· From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,
Biochim Biophys Acta. 2015 Oct 26.
· Developmental clock compromises human twin model created by embryo splitting
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,
Hum Reprod. 2015 Oct 21
· MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
and can be explored for human embryo reproductive competence assessment
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.
Fertil Steril. 2015 Oct 9
· Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
provide insights into tumor biology and therapeutic leads.
Auguste
A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
Galmiche L, Kalfa N, Veitia RA
Hum Mol Genet. 2015 Sep 11.
· TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.
NAR. 2015 Aug
· SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.
Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.
Gene, 2015 Jul.
· DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.
Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.
Blood. 2015 Apr 16
· Disruption of SF3B1 results in deregulated expression and splicing of key genes
and pathways in myelodysplastic syndrome hematopoietic stem and
progenitor cells
H
Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
1092–1103
· Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.
Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.
Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.
· Expression of the potential therapeutic target CXXC5 in primary acute myeloid
leukemia cells – high expression is associated with adverse prognosis as
well as altered intracellular signaling and transcriptional regulation.
Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.
Oncotarget. 2014 Dec 26
· Acquired resistance to endocrine treatments is associated to tumor-specific
molecular changes in patient-derived luminal breast cancer xenografts.
Cottu
PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
Roman-Roman S, Marangoni E.
Clin Cancer Res. 2014 Aug 15;20(16):4314-25.
· Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.
Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.
Cell Reports. 2014 May 10
· Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia
IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.
EMBO Rep., 2014 Mar 17
· RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.
Mol Cell. 2013 Dec
· Sudemycin E influences alternative splicing and changes chromatin modifications.
Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.
Nucleic Acids Res. 2014 Mar 11.
· A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer
Pesson
M, Volant A, Uguen A, Trillet K, De La Grange P, Aubry M, Daoulas M,
Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.
PLoS One. 2014 Feb 6.
· A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
application to the study of genes involved in the response to targeted
anticancer therapies
Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.
Mol. Cancer, 2014 Jan.
· Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S
PLoS One. 2013 Dec.
· CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.
Astori
A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
Lillehaug JR, Pendino F, Bruserud O
Oncotarget, 2013 Aug.
· BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
of AML by targeting primitive LSK and progenitor cells.
Beurlet
S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
West R, Fenaux P, Chomienne C, Padua RA.
Blood. 2013 Aug
· SF3B1 mutations are associated with alternative splicing in uveal melanoma.
Furney
SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
R.
Cancer Discov. 2013 Jul 16
· Molecular characterization of a patient presumed to have prader-willi syndrome.
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.
Clin Med Insights Case Rep. 2013 May 10.
· Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.
Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.
Cell Reprogram. 2013 May 10.
· Genome
wide array analysis indicates that an amyotrophic lateral sclerosis
mutation of FUS causes an early increase of CAMK2N2 in vitro.
Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.
Biochim Biophys Acta. 2013 Mar
· Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.
Nucleic Acids Res. 2013 Feb 7.
· hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.
Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.
EMBO J. 2013 Feb 5. , DOI
· Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.
Sonia
Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
Renato C. Monteiro, Pierre de la Grange, Richard Moreau
J Hepatol. 2013 Jan 12. , DOI
· The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.
Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.
EMBO Mol Med. 2013 Jan 9. , DOI
· Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.
Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.
PLoS One. 2012;7(12):e51266. , DOI
· TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.
Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.
Oncogene. 2012 Nov 5. , DOI
· Argonaute proteins couple chromatin silencing to alternative splicing.
Ameyar-Zazoua
M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
C, Batsché E, Harel-Bellan A.
Nat Struct Mol Biol. 2012 Sep 9
· Lipocalin
2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
downstream of NFAT1 to regulate breast cancer cell invasion.
Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.
J Cell Sci. 2012 Jul 5.
· A transcriptome signature of endothelial lymphatic cells coexists with
the chronic oxidative stress signature in radiation-induced
post-radiotherapy breast angiosarcomas.
Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.
Carcinogenesis. 2012 May 7.,
· Sperm transcriptome profiling in oligozoospermia.
Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.
J Assist Reprod Genet. 2012 Jan;29(1):3-10
· Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.
Jia Y, Mu JC, Ackerman SL.
Cell. 2012 Jan 20;148(1-2):296-308
· Identification
of novel androgen-regulated pathways and mRNA isoforms through
genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan
P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
Leung HY, Elliott DJ.
PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14
· Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.
Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.
Human Molecular Genetics 2011, Jun 30
· Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Fugier
C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
Bassez G, Laporte J, Furling D, Charlet-Berguerand N.
Nat Med. 2011 May 29
· Melanoma
spheroids grown under neural crest cell conditions are highly plastic
migratory/invasive tumor cells endowed with immunomodulator function.
Ramgolam
K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R
PLoS One 2011;6(4):e18784
· Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.
Saint-André V, Batsché E, Rachez C, Muchardt C.
Nature Structural and Molecular Biology 2011, 18(3):337-44
· Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.
Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.
Nat Struct Mol Biol. 2010 Aug 15
· Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.
Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.
Cancer Research 2010 Apr 20.
· Splicing factor and exon profiling across human tissues.
de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.
Nucleic Acids Research. 2010 Jan 27.
· Exon-Based
Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
Exons Whose Expression Is Associated with Metastasis.
Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.
Cancer Research 2010 Jan 26.
· Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.
El-Bchiri
J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.
PLoS ONE. 2008, 3(7):e2583.
· Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.
Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.
Mol Cell Biol. 2007, 27(20):7315-33.
· A new advance in alternative splicing databases: from catalogue to
detailed analysis of regulation of expression and function of human
alternative splicing variants.
de la Grange P, Dutertre M, Correa M, Auboeuf D.
BMC Bioinformatics 2007, 8:180
· ASEtrap: a biological method for speeding up the exploration of spliceomes.
Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.
Genome Res. 2006, 16(6):776-86.
· FAST DB: a website resource for the study of the expression regulation of human gene products.
de la Grange P, Dutertre M, Martin N, Auboeuf D.
Nucleic Acids Research 2005, 33(13):4276-4284.
PMI
Eur J Hum Genet. 2022 Mar 11.
Brain. 2022 Mar 17
Rat Spinal Cord Injury Associated with Spasticity Leads to Widespread Changes in the Regulation of Retained Introns
Single-cell transcriptomics reveals age-resistant maintenance of cell identities, stem cell compartments and differentiation trajectories in long-lived naked mole-rats skin
- Myelodysplastic Syndrome associated TET2 mutations affect NK cell function and genome methylation
Maxime
Boy, Valeria Bisio, Lin-Pierre Zhao, Fabien Guidez, Bérénice Schell,
Emilie Lereclus, Guylaine Henry, Juliette Villemonteix, Fernando
Rodrigues-Lima, Katia Gagne, Christelle Retiere, Lise Larcher, Rathana
Kim, Emmanuelle Clappier, Marie Sebert, Arsène Mekinian, Olivier Fain,
Anne Caignard, Marion Espeli, Karl Balabanian, Antoine Toubert, Pierre
Fenaux, Lionel Ades, Nicolas DulphyNat Commun. 2023 Feb 03 / 36737440
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming
- BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Int J Mol Sci. 2021 Sep 30 / PMID: 34638998
- Cytogenetic and molecular abnormalities in Waldenström’s macroglobulinemia patients: correlations and prognostic impact
Clotilde Bravetti, Frédéric Davi, Marine Armand, Luce Smagghe, Jonathan
Caron, Olivier A Bernard, Santos Susin, Elise Chapiro, Véronique
Leblond, Florence Nguyen-Khac, Damien Roos-Weil, FILO (French Innovative
Leukemia Organization) group
- Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Gautier Stoll, Allan Sauvat, Pamela Caudana, Jimena Tosello Boari, Norma
Bloy, Sylvie Lachkar, Isabelle Martins, Paule Opolon, Andrea Checcoli,
Agathe Delaune, Noémie Robil, Pierre de la Grange, Juliette Hamroune,
Franck Letourneur, Gwennhael Autret, Patrick S C Leung, M Eric Gershwin,
Jie S Zhu, Mark J Kurth, Bouchra Lekbaby, Jérémy Augustin, Youra Kim,
Shashi Gujar, Cédric Coulouarn, Laura Fouassier, Laurence Zitvogel,
Eliane Piaggio, Chantal Housset, Patrick Soussan, Maria Chiara Maiuri,
Guido Kroemer, Jonathan G Pol
- Genes coding for transcription factors involved in stem cell
maintenance are repressed by TGF-β and downstream of Slug/Snail2 in
COPD bronchial epithelial progenitors.
Pierre de la Grange , Ariane Jolly , Charlotte Courageux , Chamseddine Ben Brahim , Pascale Leroy.
Mol Biol Rep. 2021 Aug 26 / PMID: 34436724
- Oligodendrocyte Secreted Factors Shape Hippocampal GABAergic Neuron Transcriptome and Physiology.
Elisa Mazuir, Louis Richevaux, Merie Nassar, Noémie Robil, Pierre de
la Grange, Catherine Lubetzki, Desdemona Fricker, Nathalie Sol-Foulon.
Cereb Cortex. 2021 May 21 / PMID: 34023893
- Wnt/β-catenin pathway and cell adhesion deregulation in CSDE1-related intellectual disability and autism spectrum disorders.
Briand-Suleau, P De La Grange, V Nau, T Gaillon, T Bienvenu, H
Jacquemin-Sablon, M Goossens, S Amselem, I Giurgea
- Activation of Macrophages by Lysophosphatidic Acid through
the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple
Sclerosis Pathogenesis.
Jennifer Fransson, Ana Isabel Gómez-Conde, Jesús
Romero-Imbroda, Oscar Fernández, Laura Leyva, Fernando Rodríguez de
Fonseca, Jerold Chun, Celine Louapre, Anne Baron Van-Evercooren,
Violetta Zujovic, Guillermo Estivill-Torrús, Beatriz García-Díaz.
Mol Neurobiol. 2021 Feb / PMID: 32974731
· Characterization of Blood Immune Cells in Patients With Decompensated Cirrhosis Including ACLF.
Emmanuel
Weiss, Pierre de la Grange, Mylène Defaye, Juan José Lozano, Ferrán
Aguilar, Pushpa Hegde, Ariane Jolly, Lucile Moga, Sukriti Sukriti,
Banwari Agarwal, Haqeeqat Gurm, Marion Tanguy, Johanne Poisson, Joan
Clària, Paer-Selim Abback, Axel Périanin, Gautam Mehta, Rajiv Jalan,
Claire Francoz, Pierre-Emmanuel Rautou, Sophie Lotersztajn, Vicente
Arroyo, François Durand, Richard Moreau. Front Immunol. 2021 Feb 5
· Proliferation Genes Repressed by TGF-β Are Downstream of Slug/Snail2 in Normal Bronchial Epithelial Progenitors and Are Deregulated in COPD.
Ben
Brahim C, Courageux C, Jolly A, Ouine B, Cartier A, de la Grange P, de
Koning L, Leroy P. Stem Cell Rev Rep. 2021 Jan 26. doi:
10.1007/s12015-021-10123-z.
· Frequent SLC35A2 brain mosaicism in mild malformation of cortical development
with oligodendroglial hyperplasia in epilepsy (MOGHE)
Thomas
Bonduelle, Till Hartlieb, Sara Baldassari, Nam Suk Sim, Se Hoon Kim,
Hoon-Chul Kang, Katja Kobow, Roland Coras, Mathilde Chipaux, Georg
Dorfmüller, Homa Adle-Biassette, Eleonora Aronica, Jeong Ho Lee, Ingmar
Blumcke, Stéphanie Baulac
Acta Neuropathol Commun. 2021 Jan 6;9(1):3. doi: 10.1186/s40478-020-01085-3.
· Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?
Lerebours
F, Vacher S, Guinebretiere JM, Rondeau S, Caly M, Gentien D, Van Laere
S, Bertucci F, de la Grange P, Bièche L, Liang X, Callens C.
J Adv Res. 2020 Aug 19;28:77-85. doi: 10.1016/j.jare.2020.08.009. eCollection 2021 Feb.
· Plasma microRNA signature in presymptomatic and symptomatic subjects with
C9orf72-associated frontotemporal dementia and amyotrophic lateral
sclerosis.
Kmetzsch
V, Anquetil V, Saracino D, Rinaldi D, Camuzat A, Gareau T, Jornea L,
Forlani S, Couratier P, Wallon D, Pasquier F, Robil N, de la Grange P,
Moszer I, Le Ber I, Colliot O, Becker E; PREV-DEMALS study group.
J Neurol Neurosurg Psychiatry. 2020 Nov 25:jnnp-2020-324647. doi: 10.1136/jnnp-2020-324647.
· Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.
Casulleras
M, Flores-Costa R, Duran-Güell M, Alcaraz-Quiles J, Sanz S, Titos E,
López-Vicario C, Fernández J, Horrillo R, Costa M, de la Grange P,
Moreau R, Arroyo V, Clària J.
Sci Transl Med. 2020 Oct 21;12(566):eaax5135.
· Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.
Chiot
A, Zaïdi S, Iltis C, Ribon M, Berriat F, Schiaffino L, Jolly A, de la
Grange P, Mallat M, Bohl D, Millecamps S, Seilhean D, Lobsiger CS,
Boillée S.
Nat Neurosci. 2020 Oct 19.
· Prognostic impact of cancer stem cell markers ABCB1, NEO1 and HIST1H2AE in colorectal cancer.
Bogdan
Badic, Stéphanie Durand, Flaria El Khoury, Pierre de La Grange, David
Gentien, Brigitte Simon, Catherine Le Jossic-Corcos, Laurent Corcos
Am J Transl Res. 2020 Sep 15;12(9):5797-5807. eCollection 2020.
· Plasma or serum? A qualitative study on rodents and humans using high-throughput microRNA sequencing for circulating biomarkers.
Dufourd T, Robil N, Mallet D, Carcenac C, Boulet S, Brishoual S, Rabois E, Houeto JL, de la Grange P, Carnicella S.
Biol Methods Protoc. 2019 Jun 25;4(1):bpz006. doi: 10.1093/biomethods/bpz006. eCollection 2019
· Laminin-binding integrins are essential for the maintenance of functional mammary secretory epithelium in lactation.
Romagnoli
M, Bresson L, Di-Cicco A, Pérez-Lanzón M, Legoix P, Baulande S, de la
Grange P, De Arcangelis A, Georges-Labouesse E, Sonnenberg A, Deugnier
MA, Glukhova MA, Faraldo MM.
Development. 2020 Feb 17;147(4):dev181552. doi: 10.1242/dev.181552
· ADAR1 mediated regulation of neural crest derived melanocytes and Schwann cell development.
Gacem
N, Kavo A, Zerad L, Richard L, Mathis S, Kapur RP, Parisot M, Amiel J,
Dufour S, de la Grange P, Pingault V, Vallat JM, Bondurand N.
Nat Commun. 2020 Jan 10;11(1):198. doi: 10.1038/s41467-019-14090-5
· Sam68 binds Alu-rich introns in SMN and promotes pre-mRNA circularization.
Pagliarini V, Jolly A, Bielli P, Di Rosa V, De la Grange P, Sette C.
Nucleic Acids Res. 2020 Jan 24;48(2):633-645. doi: 10.1093/nar/gkz1117
· An embryonic CaVβ1 isoform promotes muscle mass maintenance via GDF5 signaling in adult mouse.
Traoré
M, Gentil C, Benedetto C, Hogrel JY, De la Grange P, Cadot B,
Benkhelifa-Ziyyat S, Julien L, Lemaitre M, Ferry A, Piétri-Rouxel F,
Falcone S
Sci Transl Med. 2019 Nov 6;11(517). pii: eaaw1131
· A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.
Lévesque
S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco
EE, Wang Y, Vacchelli E, Stoll G, Jolly A, de La Grange P, Zitvogel L,
Kroemer G, Pol JG
Oncoimmunology. 2019 Sep 7;8(11):e1657375
· SpliceLauncher: a tool for detection, annotation and relative quantification of alternative junctions from RNAseq data.
Leman
R, Harter V, Atkinson A, Davy G, Rousselin A, Muller E, Castéra L,
Lemoine F, de la Grange P, Guillaud-Bataille M, Vaur D, Krieger S
Bioinformatics. 2019 Oct 16. pii: btz784
· Landscape of ribosome-engaged transcript isoforms reveals extensive neuronal-cell-class-specific alternative splicing programs
Furlanis E, Traunmüller L, Fucile G, Scheiffele P.
Nat Neurosci. 2019 Aug 26. doi: 10.1038/s41593-019-0465-5
· Dissecting the genetic basis of focal cortical dysplasia: a large cohort study
Baldassari
S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau
C, Dorison N, Fohlen M, Polivka M, Weckhuysen S, Dorfmüller G, Chipaux
M, Baulac S
Acta Neuropathol. 2019 Aug 23. doi: 10.1007/s00401-019-02061-5
· Blood transcriptomic biomarker as a surrogate of ischemic brain gene expression
Ramsay L, Quillé ML, Orset C, de la Grange P, Rousselet E, Férec C, Le Gac G, Génin E, Timsit S
Ann Clin Transl Neurol. 2019 Aug 10. doi: 10.1002/acn3.50861
· Lethal Poisoning of Cancer Cells by Respiratory Chain Inhibition plus Dimethyl α-Ketoglutarate.
Sica
V, Bravo-San Pedro JM, Izzo V, Pol J, Pierredon S, Enot D, Durand S,
Bossut N, Chery A, Souquere S, Pierron G, Vartholomaiou E, Zamzami N,
Soussi T, Sauvat A, Mondragón L, Kepp O, Galluzzi L, Martinou JC,
Hess-Stumpp H, Ziegelbauer K, Kroemer G, Maiuri MC.
Cell Rep. 2019 Apr 16;27(3):820-834.e9. doi: 10.1016/j.celrep.2019.03.058.
· Crizotinib-induced immunogenic cell death in non-small cell lung cancer.
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Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E,
Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S,
Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V,
Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G.
Nat Commun. 2019 Apr 2;10(1):1486
· Deciphering the Mammary Stem Cell Niche: A Role for Laminin-Binding Integrins.
Romagnoli
M, Cagnet S, Chiche A, Bresson L, Baulande S, de la Grange P, De
Arcangelis A, Kreft M, George-Labouesse E, Sonnenberg A, Deugnier MA,
Raymond K, Glukhova MA, Faraldo MM.
Stem Cell Reports. 2019 Mar 5. pii: S2213-6711(19)30056-6
· Comparison of human isogeneic Wharton’s jelly MSCs and iPSC-derived MSCs reveals
differentiation-dependent metabolic responses to IFNG stimulation.
Devito L, Klontzas ME, Cvoro A, Galleu A, Simon M, Hobbs C, Dazzi F, Mantalaris A, Khalaf Y, Ilic D.
Cell Death Dis. 2019 Mar 20;10(4):277
· Functional Interaction between U1snRNP and Sam68 Insures Proper 3′ End Pre-mRNA Processing during Germ Cell Differentiation.
Naro C, Pellegrini L, Jolly A, Farini D, Cesari E, Bielli P, de la Grange P, Sette C.
Cell Rep. 2019 Mar 12;26(11):2929-2941
· p53 controls the plasticity of mammary luminal progenitor cells downstream of Met signaling.
Chiche A, Di-Cicco A, Sesma-Sanz L, Bresson L, de la Grange P, Glukhova MA, Faraldo MM, Deugnier MA.
Breast Cancer Res. 2019 Jan 25;21(1):13
· Both anti-inflammatory and antiviral properties of novel drug candidate ABX464 are mediated by modulation of RNA splicing.
Vautrin A, Manchon L, Garcel A, Campos N, Lapasset L, Laaref AM, Bruno R, Gislard M, Dubois E, Scherrer D, Ehrlich JH, Tazi J.
Sci Rep. 2019 Jan 28;9(1):792
· Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection.
Daruich
A, Le Rouzic Q, Jonet L, Naud MC, Kowalczuk L, Pournaras JA, Boatright
JH, Thomas A, Turck N, Moulin A, Behar-Cohen F, Picard E.
Sci Adv. 2019 Jan 9;5(1):eaau9940
· Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia.
Domenech
C, Maillard L, Rousseau A, Guidez F, Petit L, Clay D, de la Grange P,
Robil N, Sanfilippo S, Guimiot F, Pla M, Jacques S, Soulier J, Souyri M.
Stem Cell Reports 2018, Nov 13;11(5):1075-1091
· The iron chelator deferasirox synergizes with chemotherapy to treat triple negative breast cancers.
Tury
S, Assayag F, Bonin F, Chateau-Joubert S, Servely JL, Vacher S, Becette
V, Caly M, Rapinat A, Gentien D, de la Grange P, Schnitzler A,
Lallemand F, Marangoni E, Bièche I, Callens C.
J Pathol. 2018 Jun 7
· Identification of novel recurrent ETV6-IGH fusions in primary central nervous system lymphoma.
Bruno,
A, Labreche, K, Daniau, M, Boisselier, B, Gauchotte, G, Royer-Perron,
L, Rahimian, A, Lemoine, F, de la Grange, P, Guégan, J, Bielle, F,
Polivka, M, Adam, C, Meyronet, D, Figarella-Branger, D, Villa, C,
Chrétien, F, Eimer, S, Davi, F, Rousseau, A, Houillier, C, Soussain, C,
Mokhtari, K, Hoang-Xuan, K, Alentorn, A.
Neuro Oncol. 2018 Jul 5;20(8):1092-1100
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595.
· Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1.
Cifdaloz
M, Osterloh L, Graña O, Riveiro-Falkenbach E, Ximénez-Embún P, Muñoz J,
Tejedo C, Calvo TG, Karras P, Olmeda D, Miñana B, Gómez-López G, Cañon
E, Eyras E, Guo H, Kappes F, Ortiz-Romero PL, Rodríguez-Peralto JL,
Megías D, Valcárcel J, Soengas MS.
Nat Commun. 2017 Dec 21;8(1):2249.
· Effects of maternal obesity on Wharton’s Jelly mesenchymal stromal cells.
Badraiq H, Cvoro A, Galleu A, Simon M, Miere C, Hobbs C, Schulz R, Siow R, Dazzi F, Ilic D.
Sci Rep. 2017 Dec 14;7(1):17595
· Cancer-associated fibroblasts induce metalloprotease-independent cancer cell invasion of the basement membrane
Glentis
A, Oertle P, Mariani P, Chikina A, El Marjou F, Attieh Y, Zaccarini F,
Lae M, Loew D, Dingli F, Sirven P, Schoumacher M, Gurchenkov BG,
Plodinec M, Vignjevic DM.
Nat Commun. 2017 Oct 13;8(1):924.
· hnRNPM guides an alternative splicing program in response to inhibition of the PI3K/AKT/mTOR pathway in Ewing sarcoma cell
Passacantilli I, Frisone P, De Paola E, Fidaleo M, Paronetto MP.
Nucleic Acids Res. 2017 Oct 3
· Neurotrophic factors for motor neurons: an à la carte menu
Alory A, Jacquier A, Gentien D, de la Grange P, Haase G.
Med Sci (Paris). 2017 Oct;33(10):835-839
· Detecting Splicing Patterns in Genes Involved in Hereditary Breast and Ovarian Cancer.
Grégoire
Davy, Antoine Rousselin, Nicolas Goardon, Laurent Castéra, Valentin
Harter, Angelina Legros, Etienne Muller, Robin Fouillet, Baptiste
Brault, Anna S. Smirnova, Fréderic Lemoine, Pierre de la Grange, Marine
Guillaud-Bataille, Virginie Caux-Moncoutier, Claude Houdayer, Françoise
Bonnet, Cécile Blanc-Fournier, Pascaline Gaildrat, Thierry Frebourg,
Alexandra Martins, Dominique Vaur, Sophie Krieger.
Eur J Hum Genet. 2017 Oct;25(10):1147-1154
· Micronuclei Frequency in Tumors Is a Predictive Biomarker for Genetic Instability
and Sensitivity to the DNA Repair Inhibitor AsiDNA.
Jdey W1, Thierry S, Popova T, Stern MH, Dutreix M.
Cancer Res. 2017 Aug 15;77(16):4207-4216
· Pre-therapy liver transcriptome landscape in Indian and French patients with severe
alcoholic hepatitis and steroid responsiveness
Shvetank
Sharma, Jaswinder S. Maras, Sukanta Das, Shabir Hussain, Ashwani K.
Mishra, Saggere M. Shasthry, Chhagan B. Sharma, Emmanuel Weiss, Laure
Elkrief, Pierre-Emmanuel Rautou, Hélène Gilgenkrantz, Sophie
Lotersztajn, Valérie Paradis, Pierre de la Grange, Christophe Junot,
Richard Moreau & Shiv K. Sarin.
Scientific Reports 2017 Jul 28;7(1):6816
· Alternative splicing of CNOT7 diversifies CCR4-NOT functions.
Chapat C, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L.
Nucleic Acids Res. 2017 Jun 7
· Translation in astrocyte distal processes sets molecular heterogeneity at the gliovascular interface.
Boulay
AC, Saubaméa B, Adam N, Chasseigneaux S, Mazaré N, Gilbert A, Bahin M,
Bastianelli L, Blugeon C, Perrin S, Pouch J, Ducos B, Le Crom S,
Genovesio A, Chrétien F, Declèves X, Laplanche JL, Cohen-Salmon M.
Cell Discov. 2017 Mar 28
· An orchestrated intron retention program in meiosis controls timely usage of transcripts during germ cell differentiation
Naro C, Jolly A, Di Persio S, BielliP, Setterblad N, Alberdi AJ, Vicini E, Geremia R, de la Grange P, Claudio Sette C.
Developmental Cell 2017 Mar 24
· Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons.
Schaller S, Buttigieg D, Alory A, Jacquier A, Barad M, Merchant M, Gentien D, de la Grange P, Haase G.
Proc Natl Acad Sci U S A. 2017 Mar 7
· Pharmacological modulation of LMNA SRSF1-dependent splicing abrogates diet-induced obesity in mice.
Santo
J, Lopez-Herrera C, Apolit C, Bareche Y, Lapasset L, Chavey C, Capozi
S, Mahuteau-Betzer F, Najman R, Fornarelli P, Lopez-Mejía IC, Béranger
G, Casas F, Amri EZ, Pau B, Scherrer D, Tazi J.,
Int J Obes (Lond). 2017
· Type I interferon signaling in systemic immune cells from patients with alcoholic cirrhosis and its association with outcome.
Weiss
E, Rautou PE, Fasseu M, Giabicani M, de Chambrun M, Wan J, Minsart C,
Gustot T, Couvineau A, Maiwall R, Hurtado-Nedelec M, Pilard N, Lebrec D,
Valla D, Durand F, de la Grange P, Monteiro RC, Paugam-Burtz C,
Lotersztajn S, Moreau R.,
J Hepatol. 2016 Dec 28
· Deregulation of pre-messenger RNA splicing and rare diseases.
de la Grange P.
Med Sci (Paris). 2016 Dec
· Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Mauger O, Lemoine F, Scheiffele P.,
Neuron. 2016 Nov 21
· Sam68 promotes self-renewal and glycolytic metabolism in mouse neural
progenitor cells by modulating Aldh1a3 pre-mRNA 3′-end processing.
La Rosa P, Bielli P, Compagnucci C, Cesari E, Volpe E, Farioli Vecchioli S, Sette C
Elife. 2016 Nov 15
· Transcriptional Elongation Regulator 1 Affects Transcription and Splicing of Genes
Associated with Cellular Morphology and Cytoskeleton Dynamics and Is
Required for Neurite Outgrowth in Neuroblastoma Cells and Primary
Neuronal Cultures.
Munoz-Cobo JP, Sanchez-Hernandez N, Gutierrez S, El Yousfi Y, Montes M, Gallego C, Hernandez-Munain C, Suné C
Mol Neurobiol. 2016 Nov 14
· Germline and somatic mutations in the MTOR gene in focal cortical dysplasia and epilepsy.
Møller
RS, Weckhuysen S, Chipaux M, Marsan E, Taly V, Bebin EM, Hiatt SM,
Prokop JW, Bowling KM, Mei D, Conti V, de la Grange P, Ferrand-Sorbets
S, Dorfmüller G, Lambrecq V, Larsen LH, Leguern E, Guerrini R, Rubboli
G, Cooper GM, Baulac S.
Neurol Genet. 2016 Oct 31
· p53 deficiency induces cancer stem cell pool expansion in a mouse model of triple-negative breast tumors.
Chiche A, Moumen M, Romagnoli M, Petit V, Lasla H, Jézéquel P, de la Grange P, Jonkers J, Deugnier MA, Glukhova MA, Faraldo MM.
Oncogene. 2016 Oct 24
· Human Embryos Created by Embryo Splitting Secrete Significantly Lower Levels of miRNA-30c.
Noli L, Capalbo A, Dajani Y, Cimadomo D, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D
Stem Cells Dev. 2016 Oct 17
· Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing.
Klein
P, Oloko M, Roth F, Montel V, Malerba A, Jarmin S, Gidaro T, Popplewell
L, Perie S, Lacau St Guily J, de la Grange P, Antoniou MN, Dickson G,
Butler-Browne G, Bastide B, Mouly V, Trollet C.
Nucleic Acids Res. 2016 Aug 9
· Characterization of Breast Cancer Preclinical Models Reveals a Specific Pattern of Macrophage Polarization.
Vallerand
D, Massonnet G, Kébir F, Gentien D, Maciorowski Z, De la Grange P,
Sigal-Zafrani B, Richardson M, Humbert S, Thuleau A, Assayag F, de
Plater L, Nicolas A, Scholl S, Marangoni E, Weigand S, Roman-Roman S,
Savina A, Decaudin D.
PLoS One. 2016 Jul 7
· Stathmin 1/2-triggered microtubule loss mediates Golgi fragmentation in mutant SOD1 motor neurons.
Bellouze S, Baillat G, Buttigieg D, de la Grange P, Rabouille C, Haase G.
Mol Neurodegener. 2016 Jun
· Involvement of GATOR complex genes in familial focal epilepsies and focal cortical dysplasia.
Weckhuysen
S, Marsan E, Lambrecq V, Marchal C, Morin-Brureau M, An-Gourfinkel I,
Baulac M, Fohlen M, Kallay Zetchi C, Seeck M, de la Grange P, Dermaut B,
Meurs A, Thomas P, Chassoux F, Leguern E, Picard F, Baulac S.
Epilepsia 2016 May 13.
· Control of neuronal synapse specification by a highly dedicated alternative splicing program
Traunmüller L, Gomez AM, Nguyen TM, Scheiffele P.
Science. 2016 May 12
· GEP analysis validates high risk MDS and acute myeloid leukemia post MDS mice models and highlights novel dysregulated pathways.
Guerenne
L, Beurlet S, Said M, Gorombei P, Le Pogam C, Guidez F, de la Grange P,
Omidvar N, Vanneaux V, Mills K, Mufti GJ, Sarda-Mantel L, Noguera ME,
Pla M, Fenaux P, Padua RA, Chomienne C, Krief P
Hematol Oncol. 2016 Jan 27
· Proliferation and Migration of Peripheral Retinal Pigment Epithelial Cells Are
Associated with the Upregulation of Wingless-Related Integration and
Bone Morphogenetic Protein Signaling in Dark Agouti Rats.
Al-Hussaini H, Kilarkaje N, Shahabi G, Al-Mulla F.
Med Princ Pract. 2016
· Discordant Growth of Monozygotic Twins Starts at the Blastocyst Stage: A Case Study
Noli L, Capalbo A, Ogilvie C, Khalaf Y, Ilic D.,
Stem Cell Reports. 2015 Nov 11
· From transcriptomic to protein level changes in TDP-43 and FUS loss-of-function cell models.
Colombrita C, Onesto E, Buratti E, de la Grange P, Gumina V, Baralle FE, Silani V, Ratti A,
Biochim Biophys Acta. 2015 Oct 26.
· Developmental clock compromises human twin model created by embryo splitting
Noli L, Dajani Y, Capalbo A, Bvumbe J, Rienzi L, Ubaldi FM, Ogilvie C, Khalaf Y, Ilic D.,
Hum Reprod. 2015 Oct 21
· MicroRNAs in spent blastocyst culture medium are derived from trophectoderm cells
and can be explored for human embryo reproductive competence assessment
Capalbo A, Ubaldi FM, Cimadomo D, Noli L, Khalaf Y, Farcomeni A, Ilic D, Rienzi L.
Fertil Steril. 2015 Oct 9
· Molecular analyses of juvenile granulosa cell tumors bearing AKT1 mutations
provide insights into tumor biology and therapeutic leads.
Auguste
A, Bessière L, Todeschini AL, Caburet S, Sarnacki S, Prat J, D’Angelo
E, de la Grange P, Ariste O, Lemoine F, Legois B, Sultan C, Zider A,
Galmiche L, Kalfa N, Veitia RA
Hum Mol Genet. 2015 Sep 11.
· TDP-43 affects splicing profiles and isoform production of genes involved in the apoptotic and mitotic cellular pathways
De Conti L, Akinyi MV, Mendoza-Maldonado R, Romano M, Baralle M, Buratti E.
NAR. 2015 Aug
· SNORD116 and SNORD115 change expression of multiple genes and modify each other’s activity.
Falaleeva M, Surface J, Shen M, de la Grange P, Stamm S.
Gene, 2015 Jul.
· DUSP4-mediated accelerated T-cell senescence in idiopathic CD4 lymphopenia.
Bignon A, Régent A, Klipfel L, Desnoyer A, de la Grange P, Martinez V, Lortholary O, Dalloul A, Mouthon L, Balabanian K.
Blood. 2015 Apr 16
· Disruption of SF3B1 results in deregulated expression and splicing of key genes
and pathways in myelodysplastic syndrome hematopoietic stem and
progenitor cells
H
Dolatshad, A Pellagatti, M Fernandez-Mercado, BH Yip, L Malcovati, M
Attwood, B Przychodzen, N Sahgal, AA Kanapin, H Lockstone, L Scifo, P
Vandenberghe, E Papaemmanuil, CWJ Smith, PJ Campbell, S Ogawa, JP
Maciejewski, M Cazzola, KI Savage and J Boultwood. Leukemia 2015 29,
1092–1103
· Amplicon rearrangements during the extrachromosomal and intrachromosomal amplification process in a glioma.
Vogt N, Gibaud A, Lemoine F, de la Grange P, Debatisse M, Malfoy B.
Nucleic Acids Res. 2014 Dec 1;42(21):13194-205.
· Expression of the potential therapeutic target CXXC5 in primary acute myeloid
leukemia cells – high expression is associated with adverse prognosis as
well as altered intracellular signaling and transcriptional regulation.
Bruserud Ø, Reikvam H, Fredly H, Skavland J, Hagen KM, van Hoang TT, Brenner AK, Kadi A, Astori A, Gjertsen BT, Pendino F.
Oncotarget. 2014 Dec 26
· Acquired resistance to endocrine treatments is associated to tumor-specific
molecular changes in patient-derived luminal breast cancer xenografts.
Cottu
PH, Bieche I, Assayag F, El Botty R, Chateau-Joubert S, Thuleau A,
Bagarre T, Albaud B, Rapinat A, Gentien D, de la Grange P, Sibut V,
Vacher S, Hatem R, Severly JL, Fontaine JJ, Decaudin D, Pierga JY,
Roman-Roman S, Marangoni E.
Clin Cancer Res. 2014 Aug 15;20(16):4314-25.
· Regulation of FAS Exon Definition and Apoptosis by the Ewing Sarcoma Protein.
Paronetto MP, Bernardis I, Volpe E, Bechara E, Sebestyén E, Eyras E, Valcárcel J.
Cell Reports. 2014 May 10
· Antagonistic functions of LMNA isoforms in energy expenditure and lifespan.
Lopez-Mejia
IC, de Toledo M, Chavey C, Lapasset L, Cavelier P, Lopez-Herrera C,
Chebli K, Fort P, Beranger G, Fajas L, Amri EZ, Casas F, Tazi J.
EMBO Rep., 2014 Mar 17
· RBM5, 6, and 10 differentially regulate NUMB alternative splicing to control cancer cell proliferation.
Bechara EG, Sebestyén E, Bernardis I, Eyras E, Valcárcel J.
Mol Cell. 2013 Dec
· Sudemycin E influences alternative splicing and changes chromatin modifications.
Convertini P1, Shen M, Potter PM, Palacios G, Lagisetti C, de la Grange P, Horbinski C, Fondufe-Mittendorf YN, Webb TR, Stamm S.
Nucleic Acids Res. 2014 Mar 11.
· A Gene Expression and Pre-mRNA Splicing Signature That Marks the Adenoma-Adenocarcinoma Progression in Colorectal Cancer
Pesson
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Robaszkiewicz M, Le Gac G, Morel A, Simon B, Corcos L.
PLoS One. 2014 Feb 6.
· A dedicated microarray for in-depth analysis of pre-mRNA splicing events:
application to the study of genes involved in the response to targeted
anticancer therapies
Pesson M, Eymin B, De La Grange P, Simon B, Corcos L.
Mol. Cancer, 2014 Jan.
· Valproic Acid Causes Proteasomal Degradation of DICER and Influences miRNA Expression.
Zhang Z, Convertini P, Shen M, Xu X, Lemoine F, de la Grange P, Andres DA, Stamm S
PLoS One. 2013 Dec.
· CXXC5 (Retinoid-Inducible Nuclear Factor, RINF) is a Potential Therapeutic Target in High-Risk Human Acute Myeloid Leukemia.
Astori
A, Fredly H, Aloysius TA, Bullinger L, Mas VM, de la Grange P,
Delhommeau F, Hagen KM, Récher C, Dusanter-Fourt I, Knappskog S,
Lillehaug JR, Pendino F, Bruserud O
Oncotarget, 2013 Aug.
· BCL-2 inhibition with ABT-737 prolongs survival in an NRAS/BCL-2 mouse model
of AML by targeting primitive LSK and progenitor cells.
Beurlet
S, Omidvar N, Gorombei P, Krief P, Le Pogam C, Setterblad N, de la
Grange P, Leboeuf C, Janin A, Noguera ME, Hervatin F, Sarda-Mantel L,
Konopleva M, Andreeff M, Tu AW, Fan AC, Felsher DW, Whetton A, Pla M,
West R, Fenaux P, Chomienne C, Padua RA.
Blood. 2013 Aug
· SF3B1 mutations are associated with alternative splicing in uveal melanoma.
Furney
SJ, Pedersen M, Gentien D, Dumont AG, Rapinat A, Desjardins L, Turajlic
S, Piperno-Neumann S, de la Grange P, Roman-Roman S, Stern MH, Marais
R.
Cancer Discov. 2013 Jul 16
· Molecular characterization of a patient presumed to have prader-willi syndrome.
Falaleeva M, Sulsona CR, Zielke HR, Currey KM, de la Grange P, Aslanzadeh V, Driscoll DJ, Stamm S.
Clin Med Insights Case Rep. 2013 May 10.
· Human Induced Pluripotent Stem Cells As a Tool to Model a Form of Leber Congenital Amaurosis.
Lustremant C, Habeler W, Plancheron A, Goureau O, Grenot L, de la Grange P, Audo I, Nandrot EF, Monville C.
Cell Reprogram. 2013 May 10.
· Genome
wide array analysis indicates that an amyotrophic lateral sclerosis
mutation of FUS causes an early increase of CAMK2N2 in vitro.
Convertini P, Zhang J, de la Grange P, Hayward L, Zhu H, Stamm S.
Biochim Biophys Acta. 2013 Mar
· Pyrvinium pamoate changes alternative splicing of the serotonin receptor 2C by influencing its RNA structure.
Shen M, Bellaousov S, Hiller M, de La Grange P, Creamer TP, Malina O, Sperling R, Mathews DH, Stoilov P, Stamm S.
Nucleic Acids Res. 2013 Feb 7.
· hCAF1/CNOT7 regulates interferon signalling by targeting STAT1.
Chapat C, Kolytcheff C, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S, Corbo L.
EMBO J. 2013 Feb 5. , DOI
· Gene- and exon-expression profiling reveals an extensive LPS-induced response in immune cells in patients with cirrhosis.
Sonia
Gandoura, Emmanuel Weiss, Pierre-Emmanuel Rautou, Magali Fasseu,
Thierry Gustot, Frédéric Lemoine, Margarita Hurtado-Nedelec, Caroline
Hego, Nathalie Vadrot, Laure Elkrief, Philippe Lettéron, Zéra Tellier,
Marie-Anne Pocidalo, Dominique Valla, Didier Lebrec, André Groyer,
Renato C. Monteiro, Pierre de la Grange, Richard Moreau
J Hepatol. 2013 Jan 12. , DOI
· The Huntington disease protein accelerates breast tumour development and metastasis through ErbB2/HER2 signaling.
Moreira Sousa C, McGuire JR, Thion MS, Gentien D, de la Grange P, Tezenas du Montcel S, Vincent-Salomon A, Durr A, Humbert S.
EMBO Mol Med. 2013 Jan 9. , DOI
· Global Profiling of Alternative Splicing Events and Gene Expression Regulated by hnRNPH/F.
Wang E, Aslanzadeh V, Papa F, Zhu H, de la Grange P, Cambi F.
PLoS One. 2012;7(12):e51266. , DOI
· TAF15 is important for cellular proliferation and regulates the expression of a subset of cell cycle genes through miRNAs.
Ballarino M, Jobert L, Dembélé D, de la Grange P, Auboeuf D, Tora L.
Oncogene. 2012 Nov 5. , DOI
· Argonaute proteins couple chromatin silencing to alternative splicing.
Ameyar-Zazoua
M, Rachez C, Souidi M, Robin P, Fritsch L, Young R, Morozova N, Fenouil
R, Descostes N, Andrau JC, Mathieu J, Hamiche A, Ait-Si-Ali S, Muchardt
C, Batsché E, Harel-Bellan A.
Nat Struct Mol Biol. 2012 Sep 9
· Lipocalin
2 (LCN2), the TNF-like receptor TWEAKR and its ligand TWEAK act
downstream of NFAT1 to regulate breast cancer cell invasion.
Gaudineau B, Fougère M, Guaddachi F, Lemoine F, de la Grange P, Jauliac S.
J Cell Sci. 2012 Jul 5.
· A transcriptome signature of endothelial lymphatic cells coexists with
the chronic oxidative stress signature in radiation-induced
post-radiotherapy breast angiosarcomas.
Hadj-Hamou NS, Laé M, Almeida A, de la Grange P, Kirova Y, Sastre-Garau X, Malfoy B.
Carcinogenesis. 2012 May 7.,
· Sperm transcriptome profiling in oligozoospermia.
Montjean D, de La Grange P, Gentien D, Rapinat A, Belloc S, Cohen-Bacrie P, Menezo Y, Benkhalifa M.
J Assist Reprod Genet. 2012 Jan;29(1):3-10
· Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration.
Jia Y, Mu JC, Ackerman SL.
Cell. 2012 Jan 20;148(1-2):296-308
· Identification
of novel androgen-regulated pathways and mRNA isoforms through
genome-wide exon-specific profiling of the LNCaP transcriptome.
Rajan
P, Dalgliesh C, Carling PJ, Buist T, Zhang C, Grellscheid SN, Armstrong
K, Stockley J, Simillion C, Gaughan L, Kalna G, Zhang MQ, Robson CN,
Leung HY, Elliott DJ.
PLoS One. 2011;6(12):e29088. Epub 2011 Dec 14
· Modeling neuronal defects associated with a lysosomal disorder using patient-derived induced pluripotent stem cells.
Lemonnier T, Blanchard S, Toli D, Roy E, Bigou S, Froissart R, Rouvet I, Vitry S, Heard JM, Bohl D.
Human Molecular Genetics 2011, Jun 30
· Misregulated alternative splicing of BIN1 is associated with T tubule alterations and muscle weakness in myotonic dystrophy.
Fugier
C, Klein AF, Hammer C, Vassilopoulos S, Ivarsson Y, Toussaint A, Tosch
V, Vignaud A, Ferry A, Messaddeq N, Kokunai Y, Tsuburaya R, de la Grange
P, Dembele D, Francois V, Precigout G, Boulade-Ladame C, Hummel MC, de
Munain AL, Sergeant N, Laquerrière A, Thibault C, Deryckere F, Auboeuf
D, Garcia L, Zimmermann P, Udd B, Schoser B, Takahashi MP, Nishino I,
Bassez G, Laporte J, Furling D, Charlet-Berguerand N.
Nat Med. 2011 May 29
· Melanoma
spheroids grown under neural crest cell conditions are highly plastic
migratory/invasive tumor cells endowed with immunomodulator function.
Ramgolam
K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM,
Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R
PLoS One 2011;6(4):e18784
· Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.
Saint-André V, Batsché E, Rachez C, Muchardt C.
Nature Structural and Molecular Biology 2011, 18(3):337-44
· Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB.
Llorian M, Schwartz S, Clark TA, Hollander D, Tan LY, Spellman R, Gordon A, Schweitzer AC, de la Grange P, Ast G, Smith CW.
Nat Struct Mol Biol. 2010 Aug 15
· Estrogen Regulation and Physiopathologic Significance of Alternative Promoters in Breast Cancer.
Dutertre M, Gratadou L, Dardenne E, Germann S, Samaan S, Lidereau R, Driouch K, de la Grange P, Auboeuf D.
Cancer Research 2010 Apr 20.
· Splicing factor and exon profiling across human tissues.
de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D.
Nucleic Acids Research. 2010 Jan 27.
· Exon-Based
Clustering of Murine Breast Tumor Transcriptomes Reveals Alternative
Exons Whose Expression Is Associated with Metastasis.
Dutertre M, Lacroix-Triki M, Driouch K, de la Grange P, Gratadou L, Beck S, Millevoi S, Tazi J, Lidereau R, Vagner S, Auboeuf D.
Cancer Research 2010 Jan 26.
· Nonsense-mediated mRNA decay impacts MSI-driven carcinogenesis and anti-tumor immunity in colorectal cancers.
El-Bchiri
J, Guilloux A, Dartigues P, Loire E, Mercier D, Buhard O, Sobhani I, de
la Grange P, Auboeuf D, Praz F, Fléjou JF, Duval A.
PLoS ONE. 2008, 3(7):e2583.
· Regulation of H-ras splice variant expression by cross talk between the p53 and nonsense-mediated mRNA decay pathways.
Barbier J, Dutertre M, Bittencourt D, Sanchez G, Gratadou L, de la Grange P, Auboeuf D.
Mol Cell Biol. 2007, 27(20):7315-33.
· A new advance in alternative splicing databases: from catalogue to
detailed analysis of regulation of expression and function of human
alternative splicing variants.
de la Grange P, Dutertre M, Correa M, Auboeuf D.
BMC Bioinformatics 2007, 8:180
· ASEtrap: a biological method for speeding up the exploration of spliceomes.
Thill G, Castelli V, Pallud S, Salanoubat M, Wincker P, de la Grange P, Auboeuf, D, Schächter V, Weissenbach J.
Genome Res. 2006, 16(6):776-86.
· FAST DB: a website resource for the study of the expression regulation of human gene products.
de la Grange P, Dutertre M, Martin N, Auboeuf D.
Nucleic Acids Research 2005, 33(13):4276-4284.
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