Sci Transl Med: Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis.

Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis. Mireia Casulleras, Roger Flores-Costa, Marta Duran-Güell, José Alcaraz-Quiles, Silvia Sanz, Esther Titos, Cristina López-Vicario, Javier Fernández, Raquel Horrillo, Montserrat Costa, Pierre de la Grange, Richard Moreau, Vicente Arroyo, Joan Clària. Sci Transl Med. 2020 Oct 21 Read more…

Nat Neurosci: Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival.

Modifying macrophages at the periphery has the capacity to change microglial reactivity and to extend ALS survival. Aude Chiot, Sakina Zaïdi, Charlène Iltis, Matthieu Ribon, Félix Berriat, Lorenzo Schiaffino, Ariane Jolly, Pierre de la Grange, Michel Mallat, Delphine Bohl, Stéphanie Millecamps, Danielle Seilhean, Christian S Lobsiger, Séverine Boillé. Nat Neurosci. Read more…

Oncoimmunology: A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. Lévesque S, Le Naour J, Pietrocola F, Paillet J, Kremer M, Castoldi F, Baracco EE, Wang Y, Vacchelli E, Stoll G, Jolly A, De La Grange P, Zitvogel L, Kroemer G, Pol JG. Oncoimmunology. Read more…