“Melanoma spheroids grown under neural crest cell conditions are highly plastic migratory/invasive tumor cells endowed with immunomodulator function.” Ramgolam K, Lauriol J, Lalou C, Lauden L, Michel L, de la Grange P, Khatib AM, Aoudjit F, Charron D, Alcaide-Loridan C, Al-Daccak R. PLoS One. 2011 Apr 15;6(4):e18784. DOI, Pubmed
“Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.” Saint-André V, Batsché E, Rachez C, Muchardt C. Nat Struct Mol Biol. 2011 Mar;18(3):337-44. Epub 2011 Feb 27. DOI, Pubmed
This study published in Nature Structural & Molecular Biology was done in collaboration with University of Cambridge, Tel-Aviv University and Affymetrix. Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated by PTB. Article: “Position-dependent alternative splicing activity revealed by global profiling of alternative splicing events regulated Read more…
We applied our EASANA® platform to analyze the effect of estrogen treatments on the gene expression regulation at the exon level on a breast cancer cell line (collaboration with INSERM and the Curie Institute). Article: “Estrogen regulation and physiopathologic significance of alternative promoters in breast cancer.” Dutertre M, Gratadou L, Read more…
We applied our EASANA® platform to analyze the splicing factor expression and transcriptome among 11 normal human tissues using the Affymetrix Exon Arrays (collaboration with INSERM). Article “Splicing factor and exon profiling across human tissues.” de la Grange P, Gratadou L, Delord M, Dutertre M, Auboeuf D. Nucleic Acids Res. Read more…
We applied our EASANA® platform to identify regulated exons between mammary gland primary tumors with different metastatic property. Expression of the subsequent validated splicing variants was then correlated with prognosis of breast cancer patients through restrospective study (collaboration with INSERM, CNRS and the Curie Institute). Article “Exon-based clustering of murine Read more…